Five new triterpenoidal saponins from the roots of Ilex cornuta and their protective effects against H2O2-induced cardiomyocytes injury

Wang, Wenlian; Zhao, Jianping; Li, Shanshan; Lu, You; Li, Yanli; Xu, Qiong; Li, Xiaoran; Khan, Ikhlas A.; Yang, Shilin

doi:10.1016/j.fitote.2014.08.016

Cited by 13 publications

(9 citation statements)

References 22 publications

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“…* P < 0:05, * * P < 0:01 versus control groups. BioMed Research International establishment of a H 2 O 2 cardiomyocyte model, which was consistent with previous reports [28,29].…”

Section: Discussionsupporting

confidence: 92%

Protective Effect of a Novel Polysaccharide from Lonicera japonica on Cardiomyocytes of Mice Injured by Hydrogen Peroxide

Zhou

Tang³

et al. 2020

BioMed Research International

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Lonicera japonica is a traditional Chinese herbal medicine with antioxidation, anti-inflammatory, antibacterial, and immunoregulation functions. A method to isolate polysaccharides from Lonicera japonica (LJP) has been reported previously by our group. We also reported previously that LJP was consisted of 6 types of monosaccharides and had the characteristic absorption of typical polysaccharides. In this study, we investigated the protective effect of LJP on cardiomyocytes of mice injured by hydrogen peroxide (H2O2). The results showed that LJP can increase the cardiomyocyte viability and the activities of the enzyme (SOD, CAT, GSH-Px, AST, CPK, and LDH) in cardiomyocytes of mice injured by hydrogen peroxide. The results of intracellular ROS contents showed that a high dose (40 μg mL-1) of LJP had the best effects on protecting the cardiomyocytes of mice injured by H2O2. In addition, the measurement results of the cardiomyocyte apoptosis and the activity of caspase-3, caspase-8, and caspase-9 in cardiomyocytes confirmed this conclusion from another perspective.

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“…* P < 0:05, * * P < 0:01 versus control groups. BioMed Research International establishment of a H 2 O 2 cardiomyocyte model, which was consistent with previous reports [28,29].…”

Section: Discussionsupporting

confidence: 92%

Protective Effect of a Novel Polysaccharide from Lonicera japonica on Cardiomyocytes of Mice Injured by Hydrogen Peroxide

Zhou

Tang³

et al. 2020

BioMed Research International

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“…Another two separate studies on the glucuronopyranosyl methyl ester derivatives of ursane triterpenoid saponins of I. cornuta were found to have better cardioprotective effects than their parent non-methylated saponins against H 2 O 2 induced cardiomyocyte injury along with increased cell viability at 25μM. 35 , 26 These results suggest that the esterification on glucuronic acid moiety at C-3 position of ursane saponins improve the cardioprotective effect of methylated saponins, as shown in Fig. 2 .…”

Section: Structure Activity Relationships (Sar)mentioning

confidence: 80%

“… 50 The saponins of I. cornuta exhibited protective effects against H 2 O 2 -mediated myocardial cell injury whereas did not show DPPH free radical scavenging activity (<30% at 200μM). 26 , 35 The antioxidant activity results suggested that the protective effects of saponins were not directly associated with their free radical scavenging effect and warrant to investigate further.…”

Section: Cardioprotective Activity Of Saponinsmentioning

confidence: 99%

“… 32 Saponins of Allium species, I. cornuta and Dioscorea or yam plants have been best studied against hydrogen peroxide (H 2 O 2 )-mediated oxidative injuries by generating highly reactive hydroxyl radicals. 33 , 34 , 35 Saponins, for example, glycyrrhizic acid, asperosaponin VI, elatoside C, tribulosin, platycodin D, astragaloside IV, protodioscin, and trillin are known to increase the activity of several antioxidant enzymes like super oxide dismutase (SOD), catalase and glutathione peroxidase (GSH-Px), which work at cellular defense against ROS induced cardiac damage. 24 , 36 , 37 , 38 , 39 , 40 , 41 , 42 …”

Section: Cardioprotective Activity Of Saponinsmentioning

confidence: 99%

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Structural characteristics, bioavailability and cardioprotective potential of saponins

Singh

Chaudhuri

2018

Integrative Medicine Research

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“…Triterpenoid saponins from the roots of I. cornuta exhibited protective effects against H 2 O 2 -induced cardiomyocyte injury (Wang et al, 2014a). Triterpenoid saponins from the roots of I. cornuta exhibited protective effects against H 2 O 2 -induced cardiomyocyte injury (Wang et al, 2014a).…”

Section: Effects On Cardiovascular Systemmentioning

confidence: 99%

Phytochemistry and biology of Ilex pharmaceutical resources

Hao¹,

Gu²,

Xiao³

2015

Medicinal Plants

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Five new triterpenoidal saponins from the roots of Ilex cornuta and their protective effects against H2O2-induced cardiomyocytes injury

Cited by 13 publications

References 22 publications

Protective Effect of a Novel Polysaccharide from Lonicera japonica on Cardiomyocytes of Mice Injured by Hydrogen Peroxide

Protective Effect of a Novel Polysaccharide from Lonicera japonica on Cardiomyocytes of Mice Injured by Hydrogen Peroxide

Structural characteristics, bioavailability and cardioprotective potential of saponins

Phytochemistry and biology of Ilex pharmaceutical resources

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