Five New Triterpenoid Saponins from the Rhizomes of Panacis majoris and Their Antiplatelet Aggregation Activity

Abstract

Five new triterpenoid saponins (-) and four known triterpenoid saponins, ginsenoside Re (), majonoside R (), 24()-majonoside R (), and ginsenoside Rf (), were isolated from the rhizomes of . The structures of new compounds were elucidated as (20,24,25*)-6-O-[-D-glucopyranosyl-(1 → 2)--D-glucopyranosyl]-dammar-20,24-epoxy-3,6,12,25,26-pentaol (), (20,24,25)-6-O-[-D-glucopyranosyl-(1 → 2)--D-glucopyranosyl]-dammar-20,24-epoxy-3,6,12,25,26-pentaol (), (20)-6-O-[-D-glucopyranosyl-(1 → 2)--D-glucopyranosyl]-dammar-20,25-epoxy-3,6,12,24-tetraol (), 6-O-[-D-glucopyranosyl-(1 → 2)--D-glucopyranosyl]-dammar-3,6,12,20,24,25-hexaol (), and 6-O-[-D-glucop-yranosyl-(1 → 2)--D-glucopyranosyl]-dammar-25(26)-ene-3,6,12,20,24-pentaol () on the basis of extensive spectral analysis and chemical methods. Ginsenoside Re was isolated from the plant for the first time. The similarities of the nine compounds lie in the fact that their aglycones are conjoined with the same glucopyranose moieties, the same linkage of the glycosyl chains, and the same glycosylation sites, while they have a varied C-17 side chain. Compounds and exhibited moderate antiplatelet aggregation activities induced by adenosine diphosphate with IC values of 23.24 and 18.43 µM, respectively. Compound displayed moderate inhibition of arachidonic acid-induced platelet aggregation with an IC value of 30.11 µM.

Advances and challenges in ginseng research from 2011 to 2020: the phytochemistry, quality control, metabolism, and biosynthesis

“…55–57 Detailed information with respect to these 218 isolated saponins is provided in Table S2† ( 1–218 ). 9,43,54–118…”

Endogenous and Exogenous Natural Sources of Inhibition of Arachidonic acid-induced Platelet aggregation

“…Recently, new triterpenoid saponins isolated from the rhizomes of Panacis majoris (Araliaceae) showed significant antiplatelet activity against AA (Li et al 2017). Very potent activity against platelet aggregation induced by AA was found in Ginsenoside Rk1 (6) and Rg5 (7) (Araliaceae).…”

Natural Sources of Inhibition of Adenosine Diphosphate-Induced Platelet Aggregation

“…Therefore, ADP is an important target for inhibiting platelet aggregation in various cardiovascular conditions. New triterpenoid saponins isolated from the rhizomes of Panacis majoris (Araliaceae) also showed antiplatelet activity against ADP (Table 1) (Li et al, 2017). Several compounds from the plant Selaginella moellendorffii (Selaginellaceae) showed activity against platelet aggregation induced by ADP (Zhuo et al, 2016).…”