Five New Triterpenoid Saponins from the Roots of Platycodon grandiflorum

Fu, Wenwei; Shimizu, Noriko; Dou, Deqiang; Takeda, Tadahiro; Fu, Rui; Pei, Yue‐Hu; Chen, Ying‐Jie

doi:10.1248/cpb.54.557

Cited by 42 publications

(42 citation statements)

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“…Balloon flower is valued as a horticultural plant for its balloon-shaped flower. Its roots are popular in traditional Chinese medicine because they are abundant in triterpenoid saponins (Ishii et al, 1978;Fu et al, 2006) and used as a remedy for cough, cold, bronchitis, asthma, and sore throat (Germida et al, 1998;Lee et al, 2004). The root of balloon flower is commonly called doraji in South Korea, jie geng in China, and kikyo in Japan, and total saponin content varies among the germplasm resources (Kim et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Development and characterization of 22 polymorphic microsatellite markers for the balloon flower Platycodon grandiflorum (Campanulaceae)

Song

Lee²,

Yoon³

et al. 2012

Genet. Mol. Res.

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ABSTRACT. The balloon flower (Platycodon grandiflorum A. DC.) is a perennial flowering plant of the Campanulaceae family; it is the only member of the genus Platycodon. Information on the genetic diversity of balloon flower populations is of great importance for the conservation and germplasm utilization of this flowering plant. Twenty-two polymorphic microsatellite loci were developed and characterized with eight balloon flower accessions collected from South Korea and China. Eighty-one alleles were detected among the eight balloon flower accessions. The number of alleles per locus ranged from two to six, with a mean of four alleles per locus. The observed and expected heterozygosity values ranged from 0.000 to 0.875 (mean = 0.355) and 0.117 to 0.766 (mean = 0.489), respectively. The polymorphic information content values ranged from 0.110 to 0.733, with a mean of 0.449. These new microsatellite markers will be useful for population and conservation genetic studies of P. grandiflorum.

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Section: Introductionmentioning

confidence: 99%

Development and characterization of 22 polymorphic microsatellite markers for the balloon flower Platycodon grandiflorum (Campanulaceae)

Song

Lee²,

Yoon³

et al. 2012

Genet. Mol. Res.

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“…This plant is well known to be abundant in triterpenoid saponins, and 55 such compounds have been isolated from the genus [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Platicodins have been found to exhibit varied biological activities, including anti-inflammatory, inhibition of prostaglandin E 2 production, inhibitory effects on pancreatic lipase, antiobesity and hypolipidemic effects, apoptosis induction, inhibition of inducible nitric oxide synthase and cyclooxygenase II, antitumor and immunomodulatory properties [19][20][21][22][23][24][25][26][27][28][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Triterpenoid Saponins from the Roots of Platycodon grandiflorum

2007

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Bioguided fractionation of the ethanol extracts obtained from Platycodon grandiflorum roots led to isolation of two new triterpenoid saponins, characterized as 3-O-β-D-glucopyranosyl-2β,12α,16α,23,24-pentahydroxyoleanane-28(13)-lactone (1) and 3-O-β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl-2β,12α,16α,23α-tetrahydroxyoleanane-28(13)-lactone (2) by 1D-and 2D-NMR and MS techniques, as well as chemical means. Both compounds showed cytotoxic activity against human ECA-109 cells.

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“…(Campanulaceae), which are called Jiegeng in Chinese, are widely used in traditional Chinese medicine for the treatment of cough, excessive phlegm, chest congestion, pyocutaneous disease (suppurative disease), sore throat, upper respiratory tract infections, and tonsillitis. 1,2) Previous chemical and pharmacological studies revealed that triterpenoid saponins are the primary components in P. grandiflorum, 3,4) and these saponins have been reported to have significant biological activities such as antitumor, antimicrobial, and anti-inflammatory activities. [5][6][7][8] With the aim of identifying new anti-tumor agents from this plant, we examined its ethanol extract.…”

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confidence: 99%