Five new sucrose esters from the whole plants of Phyllanthus cochinchinensis

Abstract

These authors contributed equally to this work.

Four Undescribed compounds Isolated from the Aerial Parts of Phyllanthus cochinchinensis with Antimicrobial Activity and NO Production Inhibitory Activity in LPS Activated RAW 264.7 Cells

“…Phytochemical study on the methanol extract of the aerial parts of P. cochinchinensis led to the isolation of four previously undescribed (1)(2)(3)(4) and ten known compounds (5)(6)(7)(8)(9)(10)(11)(12)(13)(14) (Figure 1). The known compounds were identified to be urolignoside (5), [6] 2-[4-[2,3-dihydro-3-(hydroxymethyl)-5-(3-hydroxypropyl)-7methoxy-2-benzofuranyl]-2,6-dimethoxyphenoxy]-1-(4-hydroxy-3-methoxyphenyl)-1,3-propanediol (6), [7] acernikol (7), [8] justicidin B (8), [9,10] restrojusticidin B (9), [10] dehydroguaiaretic acid (10), [11] caliislignan A (11), [12] pinoresinol (12), [13] kaempferol-3-Oβ-D-glucopyranoside (13), [14] isoquercitrin ( 14), [14] by 1D-, 2D-NMR, and ECD spectral data in comparison with those reported in the literature.…”

“…In addition, this plant was used to treat dysentery, diarrhea, reduce urination, eczema and scabies [1] . The previous studies have reported the presence of phenolic glycosides, limonoids, and sucrose esters from the whole plant [2–5] . Some of these compounds showed cytotoxicity, anti‐inflammarory, and antimicrobial activity.…”

“…[1] The previous studies have reported the presence of phenolic glycosides, limonoids, and sucrose esters from the whole plant. [2][3][4][5] Some of these compounds showed cytotoxicity, anti-inflammarory, and antimicrobial activity. However, up to now, there has been no report on the chemical composition and biological activity of P. cochinchinensis.…”

“…However, up to now, there has been no report on the chemical composition and biological activity of P. cochinchinensis. [2][3][4][5] This prompted us to research this medicinal plant further. Herein, we reported the isolation, structure identification of four previously undiscribed (1-4) and ten known (5)(6)(7)(8)(9)(10)(11)(12)(13)(14) compounds from the aerial parts of P. Cochinchinensis and their antimicrobial and NO production inhibitory activities.…”

“…Some of these compounds showed cytotoxicity, anti‐inflammarory, and antimicrobial activity. However, up to now, there has been no report on the chemical composition and biological activity of P. cochinchinensis [2–5] . This prompted us to research this medicinal plant further.…”