Five new flavonoid glycosides fromNervilia fordii

Abstract

Five new flavonoid glycosides, namely nervilifordins F-J (1-5), were isolated from the 60% EtOH extract of the aerial parts of Nervilia fordii, along with three first isolated flavonoids (7, 8, and 13) and five known flavonoids (6, 9-12). The structures of new compounds were elucidated on the basis of 1D and 2D NMR and MS studies. Their anti-inflammatory activities were tested by measuring their inhibitory effects on nitric oxide production in lipopolysaccharide-activated RAW264.7 macrophages. Compounds 2 and 5 showed interesting inhibition effects with their EC50 values of 15.15 μM and 14.80 μM, respectively.

Four flavonols form the whole plant of Nervilia aragoana

“…It is frequently used for the therapy of various diseases, such as bronchitis, stomatitis, acute pneumonia, and laryngitis. [1][2][3][4][5] Phytochemical studies on genus Nervilia have led to the identification of about 58 compounds, including 24 flavonoids, 10 terpenes, and some sterols and amino acids. [3] Our previous study on this plant led to the isolation of several flavonols from the ethyl acetate extract.…”

“…[1][2][3][4][5] Phytochemical studies on genus Nervilia have led to the identification of about 58 compounds, including 24 flavonoids, 10 terpenes, and some sterols and amino acids. [3] Our previous study on this plant led to the isolation of several flavonols from the ethyl acetate extract. [6] The present research reports the isolation and structure elucidation of four flavonol compounds (1)(2)(3)(4) from the remaining fractions of the ethyl acetate extract (figure 1).…”

“…[3] Our previous study on this plant led to the isolation of several flavonols from the ethyl acetate extract. [6] The present research reports the isolation and structure elucidation of four flavonol compounds (1)(2)(3)(4) from the remaining fractions of the ethyl acetate extract (figure 1).…”

Structural characterization and immunomodulating activities of a novel polysaccharide from Nervilia fordii

“…During SARS epidemic period, it showed that the decoctions of traditional Chinese herbs could significantly alleviate SARS symptoms in clinic [3,4,[6][7][8]. Thus, we have been studying the phytochemicals and pharmacological activities of Nervilia fordii since 2009 [9][10][11][12][13]. Modern pharmacological studies demonstrated that Nervilia fordii has antitumor, antiviral, analgesic, and anti-inflammatory activities [14][15][16][17].…”

“…Modern pharmacological studies demonstrated that Nervilia fordii has antitumor, antiviral, analgesic, and anti-inflammatory activities [14][15][16][17]. In our previous work, we found that the flavonoids and polysaccharides are two main constituents in Nervilia fordii which display compelling anti-inflammatory activities [10,11,13].…”