Five New Amicoumacins Isolated from a Marine-Derived Bacterium Bacillus subtilis

Li, Yongxin; Xü, Ying; Liu, Lingli; Han, Zhuang; Lai, Pok Yui; Guo, Xiangrong; Zhang, Xixiang; Lin, Wenhan; Qian, Pei‐Yuan

doi:10.3390/md10020319

Cited by 54 publications

(43 citation statements)

References 20 publications

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“…This was further supported by a comparison of cytotoxicity between compounds 36 and 42 and between 37 and 38 . A similar antibacterial effect of amide functional group has been shown among amicoumacins [62]. …”

Section: Bioactive Compoundssupporting

confidence: 64%

“…Six known analogs ( 36 – 41 ), one new bacisarcin C ( 42 ) (Figure 12) and four novel amicoumacins, lipoamicoumacins A–D ( 43 – 46 ) (Figure 13) were isolated from the culture broth of a marine-derived bacterium, B. subtilis B1779 [62]. The strain B1779 was isolated from a marine sediment sample, which was collected from the Red Sea in April 2010.…”

Section: Bioactive Compoundsmentioning

confidence: 99%

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Diversity of Secondary Metabolites from Marine Bacillus Species: Chemistry and Biological Activity

Mondol

Shin

Islam³

2013

Marine Drugs

206

132

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Marine Bacillus species produce versatile secondary metabolites including lipopeptides, polypeptides, macrolactones, fatty acids, polyketides, and isocoumarins. These structurally diverse compounds exhibit a wide range of biological activities, such as antimicrobial, anticancer, and antialgal activities. Some marine Bacillus strains can detoxify heavy metals through reduction processes and have the ability to produce carotenoids. The present article reviews the chemistry and biological activities of secondary metabolites from marine isolates. Side by side, the potential for application of these novel natural products from marine Bacillus strains as drugs, pesticides, carotenoids, and tools for the bioremediation of heavy metal toxicity are also discussed.

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Section: Bioactive Compoundssupporting

confidence: 64%

Section: Bioactive Compoundsmentioning

confidence: 99%

Diversity of Secondary Metabolites from Marine Bacillus Species: Chemistry and Biological Activity

Mondol

Shin

Islam³

2013

Marine Drugs

206

132

View full text Add to dashboard Cite

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“…AMI is produced by several bacterial species isolated from both soil and marine environments (Itoh et al, 1982; Li et al, 2012). AMI and related compounds are active against a number of pathogenic bacteria, including Helicobacter pylori (Pinchuk et al, 2001) and methicillin-resistant Staphylococcus aureus (Lama et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Amicoumacin A Inhibits Translation by Stabilizing mRNA Interaction with the Ribosome

et al. 2014

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SUMMARY We demonstrate that the antibiotic amicoumacin A (AMI) whose cellular target was unknown, is a potent inhibitor of protein synthesis. Resistance mutations in helix 24 of the 16S rRNA mapped the AMI binding site to the small ribosomal subunit. The crystal structure of bacterial ribosome in complex with AMI solved at 2.4 Å resolution revealed that the antibiotic makes contacts with universally conserved nucleotides of 16S rRNA in the E site and the mRNA backbone. Simultaneous interactions of AMI with 16S rRNA and mRNA and the in vivo experimental evidence suggest that it may inhibit the progression of the ribosome along mRNA. Consistent with this proposal, binding of AMI interferes with translocation in vitro. The inhibitory action of AMI can be partly compensated by mutations in the translation elongation factor G.

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“…The cytotoxicity tests were carried out according to the method previously described by Li et al [30]. Briefly, HeLa cells were seeded and cultured in 96-well plates 12 h before the addition of the test samples.…”

Section: Methodsmentioning

confidence: 99%

Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis

et al. 2012

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Four new polycyclic antibiotics, citreamicin θ A (1), citreamicin θ B (2), citreaglycon A (3), and dehydrocitreaglycon A (4), were isolated from marine-derived Streptomyces caelestis. The structures of these compounds were elucidated by 1D and 2D NMR spectra. All four compounds displayed antibacterial activity against Staphylococcus haemolyticus, Staphylococcus aureus, and Bacillus subtillis. Citreamicin θ A (1), citreamicin θ B (2) and citreaglycon A (3) also exhibited low MIC values of 0.25, 0.25, and 8.0 μg/mL, respectively, against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300.

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Five New Amicoumacins Isolated from a Marine-Derived Bacterium Bacillus subtilis

Cited by 54 publications

References 20 publications

Diversity of Secondary Metabolites from Marine Bacillus Species: Chemistry and Biological Activity

Diversity of Secondary Metabolites from Marine Bacillus Species: Chemistry and Biological Activity

Amicoumacin A Inhibits Translation by Stabilizing mRNA Interaction with the Ribosome

Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis

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