Five New 2-Arylbenzofuran Derivatives from Morus wittiorum

Tan, Yong-Xia; Gong, Ting; Liu, Chao; Chen, Ruo-Yun; Yu, De‐Quan

doi:10.1248/cpb.58.579

Cited by 20 publications

(5 citation statements)

References 7 publications

(13 reference statements)

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“…Moreover, trans -resveratrol, a phytoalexin produced naturally by several plants including grape and peanut when under attack by pathogens such as bacteria or fungi, has been reported to possess a variety of biological and pharmacological actions (23), and is receiving a renewed interest as a potential nutritional supplement for extending the lifespan of humans, although there is no published evidence on any clinical trial for efficacy in humans (24). Meanwhile, 2-arylbenzofuran derivatives including moracin have recently been attracted much attention as promising phytochemicals due to their anti-cancer, anti-inflamamtory, anti-hyperlipidemic, antimicrobial, and antioxidant activities (7,14,25,26). Thus, mulberry twigs having resveratrol derivatives and moracin are useful as promising sources of nutraceuticals and cosmeceuticals.…”

Section: Resultsmentioning

confidence: 99%

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Analysis of Functional Constituents in Mulberry (Morus alba L.) Twigs by Different Cultivars, Producing Areas, and Heat Processings

Choi

Jang

Lee

et al. 2013

JFN

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Four functional constituents, oxyresveratrol 3′-O-β-D-glucoside (ORTG), oxyresveratrol (ORT), t-resveratrol (RT), and moracin (MC) were isolated from the ethanolic extract of mulberry (Morus alba L.) twigs by a series of isolation procedures, including solvent fractionation, and silica-gel, ODS-A, and Sephadex LH-20 column chromatographies. Their chemical structures were identified by NMR and FABMS spectral analysis. Quantitative changes of four phytochemicals in mulberry twigs were determined by HPLC according to cultivar, producing area, and heat processing. ORTG was a major abundant compound in the mulberry twigs, and its levels ranged from 23.7 to 105.5 mg% in six different mulberry cultivars. Three other compounds were present in trace amounts (<1 mg/100 g) or were not detected. Among mulberry cultivars examined, “Yongcheon” showed the highest level of ORTG, whereas “Somok” had the least ORTG content. Levels of four phytochemicals in the mulberry twigs harvested in early September were higher than those harvested in early July. Levels of ORTG and ORT in the “Cheongil” mulberry twigs produced in the Uljin area were higher than those produced in other areas. Generally, levels of ORTG and ORT in mulberry twigs decreased with heat processing, such as steaming, and microwaving except roasting, whereas those of RT and MC did not considerably vary according to heat processing. These results suggest that the roasted mulberry twigs may be useful as potential sources of functional ingredients and foods.

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Section: Resultsmentioning

confidence: 99%

“…In particular, the content and compositions of functional constituents in different parts of mulberry trees varied considerably amongst some Morus species (12–14). A suitable heat processing is necessary to make the best quality processed foods using mulberry twigs for removing peculiar off-flavors like smell of greens and beans.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Functional Constituents in Mulberry (Morus alba L.) Twigs by Different Cultivars, Producing Areas, and Heat Processings

Choi

Jang

Lee

et al. 2013

JFN

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“…9,10) Many benzofuran derivatives were reported to show potent anti-inflammatory activity and were among COX-2 inhibitors. 11,12) On the other hand, salicylic acid and salicylates exhibit a pronounced anti-inflammatory activity, for example the salicylanilides A and B are selective inhibitors of interlukin-12 (IL-12) p40 production which is a subunit component of IL-12 and IL-6-23. IL-12 is involved in type 1 helper T cell (TH1) mediated inflammation in both normal immune defence as well as inflammatory diseases such as rheumatoid activities, asthma, psoriases and Crohn's disease.…”

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confidence: 99%

Synthesis and Anti-inflammatory Activity of Some Benzofuran and Benzopyran-4-one Derivatives

Ragab¹,

Eid²,

Hassan³

et al. 2012

CHEMICAL & PHARMACEUTICAL BULLETIN

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New series of furosalicylic acids 3a-c, furosalicylanilides 6a-n, furobenzoxazines 8a-f, 1-benzofuran-3-arylprop-2-en-1-ones 12a,b, 6-(aryl-3-oxoprop-1-enyl)-4H-chromen-4-ones 16a-c and 6-[6-aryl-2-thioxo-2,5-dihydropyrimidin-4-yl]-4H-chromen-4-ones 17a-c were synthesized. Anti-inflammatory activity evaluation was performed using carrageenan-induced paw edema model in rats and prostaglandin E 2 (PGE 2 ) synthesis inhibition activity. Some of the tested compounds revealed comparable activity with less ulcerogenic effect than Diclofenac at a dose 100 mg/kg. All the synthesized compounds were docked on the active site of cyclooxygenase-2 (COX-2) enzyme and most of them showed good interactions with the amino acids of the active site comparable to the interactions exhibited by Diclofenac.

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“…32S, Supporting Information). Interestingly, analogues of 4 have also been reported to exist in racemic form [20]. Therefore, compound 4 was determined to be a racemic mixture of 5-(5-hydroxy-7-methyl-7-(4-methylpent-3-en-1-yl)-7H-furo[2,3-f]chromen-2-yl)benzene-1,3-diol.…”

Section: Resultsmentioning

confidence: 99%

Isoprenylated Phenolic Compounds from Morus macroura as Potent Tyrosinase Inhibitors

Wang

Gao³

et al. 2017

Planta Med

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Three new Diels-Alder adducts, macrourins E - G (1: -3: ), one new 2-arylbenzofuran, macrourin H (4: ), and eight known Diels-Alder adducts (5: -12: ) were isolated from . Their structures were elucidated through extensive analysis of spectroscopic data. TheH NMR and ECD trends in the determination of the configurations of these Diels-Alder adducts were summarized. The tyrosinase inhibitory activities of all compounds isolated were evaluated, and the new compounds (1: -4: ) as well as the eight known compounds (5: -12: ) were found to be potent with IC values ranging from 0.39 to 4.54 µM. Among them, 1 showed the best tyrosinase inhibitory activity with an IC value of 0.39 µM, approximately 50 times stronger than the positive control, kojic acid.

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Five New 2-Arylbenzofuran Derivatives from Morus wittiorum

Cited by 20 publications

References 7 publications

Analysis of Functional Constituents in Mulberry (Morus alba L.) Twigs by Different Cultivars, Producing Areas, and Heat Processings

Analysis of Functional Constituents in Mulberry (Morus alba L.) Twigs by Different Cultivars, Producing Areas, and Heat Processings

Synthesis and Anti-inflammatory Activity of Some Benzofuran and Benzopyran-4-one Derivatives

Isoprenylated Phenolic Compounds from Morus macroura as Potent Tyrosinase Inhibitors

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