Five myths about AIDS that have misdirected research and treatment

Root‐Bernstein, Robert

doi:10.1007/978-94-009-1651-7_15

Cited by 4 publications

(3 citation statements)

References 143 publications

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“…One subject confirmed to be HIV-1 ϩ by antibody test at entry subsequently tested seronegative as well as negative by PCR. Loss of HIV-1 antibody together with a negative PCR result have been demonstrated previously (16) and may be more common than formerly thought (41). Hence, this subject was retained as seropositive; eliminating him from the sample did not affect the results reported herein.…”

supporting

confidence: 53%

A Bereavement Support Group Intervention Is Longitudinally Associated with Salutary Effects on the CD4 Cell Count and Number of Physician Visits

Goodkin

Feaster

Asthana³

et al. 1998

Clin Diagn Lab Immunol

130

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A randomized, controlled, clinical trial was conducted to examine the impact of a semistructured, 10-week, once weekly, 90-min/session bereavement support group intervention on immunological, neuroendocrine, and clinical health status in human immunodeficiency virus type 1-seropositive (HIV-1+) and HIV-1-seronegative (HIV-1−) homosexual men, compared to a standard of care control condition. A total of 119 homosexual men (74 HIV-1+and 45 HIV-1−) were assessed at baseline, 10 weeks, and 6 months follow-up. At the 6-month follow-up assessment, the intervention groups exhibited significant beneficial effects compared to controls on changes in CD4 cell, total T-lymphocyte, and total lymphocyte counts, when baseline levels, antiretroviral medication use, CDC stage of disease, and other potentially confounding factors were accounted for. There was no statistically significant effect on the CD4/CD8 ratio or on the CD8 cell count. The effect on CD4 cell count was associated with group attendance and with changes in plasma cortisol level. Plasma cortisol levels decreased significantly among intervention subjects, compared to controls. A significantly reduced number of health care visits over the 6-month follow-up period among the intervention subjects supported the clinical relevance of the immunological changes observed for both HIV-1+ and HIV-1−individuals. These results indicate that behavioral interventions may have salutary immunological and clinical health effects following bereavement among HIV-1-infected individuals. The effect in HIV-1− individuals suggests that this bereavement support group intervention might have similar salutary effects in the general population. Potential effects of such interventions on clinical HIV disease progression are of interest and should be studied.

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supporting

confidence: 53%

A Bereavement Support Group Intervention Is Longitudinally Associated with Salutary Effects on the CD4 Cell Count and Number of Physician Visits

Goodkin

Feaster

Asthana³

et al. 1998

Clin Diagn Lab Immunol

130

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“…The repeated failure of HIV vaccines, and particularly of gp160 (envelope protein)-based vaccines (which have the highest similarity to TCR) is a matter of record [ 83 , 84 , 85 ]. In addition, the induction of anti-T cell autoimmunity has, been reported in some failed trials, with concomitant enhancement of HIV acquisition [ 86 , 87 , 88 ]. In fact, components of the envelope protein are actively tolerized by the human immune system [ 89 ] so that HIV-infected patients who do develop broadly neutralizing antibodies that can target multiple HIV strains also produce high levels of autoantibodies and low levels of regulatory T cells [ 90 ].…”

Section: Discussionmentioning

confidence: 99%

Human Immunodeficiency Virus Proteins Mimic Human T Cell Receptors Inducing Cross-Reactive Antibodies

Root‐Bernstein

2017

IJMS

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“…It is extremely unusual when symptomatic or asymptomatic individuals with culture- or PCR-confirmed HIV infection do not produce virus-directed antibodies and remain persistently negative beyond the expected window period. A few such cases have been reported in the literature, and most of which were due to agammaglobulinemia of unknown immune dysfunction [ 5 – 11 ]. These exceptions only reinforce the general notion that once a person is diagnosed with HIV, he or she remains antibody-positive for the rest of his or her life.…”

Section: Introductionmentioning

confidence: 99%

Serodeconversion of HIV Antibody‐Positive AIDS Patients Following Treatment with V‐1 Immunitor

Metadilogkul

Jirathitikal²,

Bourinbaiar³

2008

BioMed Research International

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It is extremely rare when HIV seropositive adult patients experience spontaneous loss of antibodies, that is, seroreversion. The disappearance of HIV antibodies was occasionally attributed to iatrogenic intervention—serodeconversion. Such interventions include: HAART; oral interferon; Chinese herbal remedies; and therapeutic AIDS vaccines derived from pooled blood. Oral therapeutic, alloimmune AIDS vaccine, V-1 Immunitor (V1), was administered to 60000 HIV-positive Thai patients. The administration of V1 resulted in serodeconversion among 23 individuals. The patient group consisted of 9 females (39%) and 14 males (61%) including two 2-year-old boys. The age range was 2–58 years with mean/median 29/29.3 years. Patients were tested seropositive for HIV at least once before being enrolled on V1. The duration of treatment until discovery of seronegative status ranged between 2 weeks and 15 months with average/median 7.2/8 months. Time to seronegativity was correlated with baseline disease stage (R = 0.62; P = .002). The seronegative status was positively associated with V1-induced undetectable or low viral load (R = 0.65; P = .0008). The odds ratio analysis comparing the outcome of our study with published surveys of diagnostic accuracy of laboratory tests suggested that the probability of HIV antibody testing error was remote (P < .000001). The possible causes responsible for this unusual phenomenon are discussed.

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Five myths about AIDS that have misdirected research and treatment

Cited by 4 publications

References 143 publications

A Bereavement Support Group Intervention Is Longitudinally Associated with Salutary Effects on the CD4 Cell Count and Number of Physician Visits

A Bereavement Support Group Intervention Is Longitudinally Associated with Salutary Effects on the CD4 Cell Count and Number of Physician Visits

Human Immunodeficiency Virus Proteins Mimic Human T Cell Receptors Inducing Cross-Reactive Antibodies

Serodeconversion of HIV Antibody‐Positive AIDS Patients Following Treatment with V‐1 Immunitor

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