Five-minute recordings of heart rate variability in obsessive–compulsive disorder, panic disorder and healthy volunteers

Slaap, B.R.

doi:10.1016/s0165-0327(02)00240-9

Cited by 46 publications

(41 citation statements)

References 40 publications

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“…Slaap, Nielen, Boshuisen, van Roon, and den Boer (2004) did not find changes in HRV between healthy controls and persons with obsessive-compulsive disorders. Thus, further studies are needed to clarify, for example, whether AN patients with depressive symptoms differ from those with or without anxiety symptoms.…”

Section: Summary and Discussioncontrasting

confidence: 64%

Heart rate variability as a measure of cardiac autonomic function in anorexia nervosa: A review of the literature

Mazurak

Enck

Muth

et al. 2010

Euro Eating Disorders Rev

102

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Twenty papers on HRV in patients with anorexia were identified and analysed, revealing three distinct positions regarding changes of autonomic nervous system (ANS) functions in patients with AN. The majority of papers identified parasympathetic/sympathetic imbalance with parasympathetic dominance and decreased sympathetic modulation; others could not replicate these findings, but instead described sympathetic dominance; finally a group of papers could not identify any autonomic differences in comparison to control samples. We conclude that in its current state of analysis HRV may not be suitable for routine assessment of ANS function in AN patients but rather remains a research tool.

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Section: Summary and Discussioncontrasting

confidence: 64%

Heart rate variability as a measure of cardiac autonomic function in anorexia nervosa: A review of the literature

Mazurak

Enck

Muth

et al. 2010

Euro Eating Disorders Rev

102

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“…Second, there was inconsistency in reports between the two studies reporting on HRV and OCD. Slaap et al (47) found that HF HRV parameters did not differ between patients and controls. Pittig et al (29), however, was the first study to report reduced HF HRV in OCD patients relative to controls.…”

Section: Discussionmentioning

confidence: 97%

“…This is particularly true for conclusions about HRV and OCD. Only two studies reported on HRV and OCD, with one study report no significant reductions (47), and one study reporting significant reductions with the caveat that the result may have been related to the use of psychotropic medications (29). We also found evidence for study heterogeneity, although this issue was addressed in part, by conducting follow-up analyses to observe the effect of specific anxiety disorders on HRV.…”

Section: Discussionmentioning

confidence: 99%

Anxiety Disorders are Associated with Reduced Heart Rate Variability: A Meta-Analysis

et al. 2014

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Background: Anxiety disorders increase risk of future cardiovascular disease (CVD) and mortality, even after controlling for confounds including smoking, lifestyle, and socioeconomic status, and irrespective of a history of medical disorders. While impaired vagal function, indicated by reductions in heart rate variability (HRV), may be one mechanism linking anxiety disorders to CVD, prior studies have reported inconsistent findings highlighting the need for meta-analysis.Method: Studies comparing resting-state HRV recordings in patients with an anxiety disorder as a primary diagnosis and healthy controls were considered for meta-analysis.Results: Meta-analyses were based on 36 articles, including 2086 patients with an anxiety disorder and 2294 controls. Overall, anxiety disorders were characterized by lower HRV [high frequency (HF): Hedges’ g = −0.29. 95% CI: −0.41 to −0.17, p < 0.001; time domain: Hedges’ g = −0.45, 95% CI: −0.57 to −0.33, p < 0.001] than controls. Panic disorder (n = 447), post-traumatic stress disorder (n = 192), generalized anxiety disorder (n = 68), and social anxiety disorder (n = 90), but not obsessive–compulsive disorder (n = 40), displayed reductions in HF HRV relative to controls (all ps < 0.001).Conclusion: Anxiety disorders are associated with reduced HRV, findings associated with a small-to-moderate effect size. Findings have important implications for future physical health and well-being of patients, highlighting a need for comprehensive cardiovascular risk reduction.

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“…Respiratory sinus arrhythmia (RSA)—the fluctuation in heart period resulting from gating of vagal input to the sinoatrial node during inspiration—has been given special attention as an index of self‐regulatory capacity at physiological (Berntson, Cacioppo, & Quigley, ), psychological (Butler, Wilhelm, & Gross, ), and behavioral levels (Beauchaine, ). While a strong case has been made for impaired RSA in PD (Friedman, ), several studies have reported null findings in these patients (Asmundson & Stein, ; Slaap, Nielen, Boshuisen, van Roon, & den Boer, ; Stein & Asmundson, ; Woodward et al., ). Moreover, several authors have argued that HRV indices provide an incomplete quantitation of cardiac regulation given the multidimensional nature of the autonomic nervous system (Berntson, Cacioppo, & Quigley, ) and the chaotic structure of RR intervals (Lipsitz & Goldberger, ).…”

mentioning

confidence: 99%

Cardiac stability at differing levels of temporal analysis in panic disorder, post‐traumatic stress disorder, and healthy controls

Fisher

Woodward

2013

Psychophysiology

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The panic disorder (PD) literature provides evidence for both physiologic rigidity and instability as pathognomonic features of this disorder. This ambiguity may be a result of viewing PD at differential levels of temporal analysis. We assessed cardiac variability across three levels of temporal scale in PD patients, posttraumatic stress disorder (PTSD) patients, and healthy controls. Sixteen healthy controls, 14 PD patients, 23 PTSD patients, and 16 PTSD+PD patients presented for a polysomnogram. Differences were assessed in respiratory sinus arrhythmia (RSA), autoregressive stability of heart rate (HR), and the number of nonspecific accelerations in HR over the night. No differences in RSA were found between groups, however; PD patients exhibited significantly lower autoregressive HR stability and all patients had significantly more HR accelerations than controls. These data reinforce prior findings demonstrating physiologic instability in PD and indicate that prior equivocalities regarding physiologic variability in PD may be due to limited temporal scaling of measurements.

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Five-minute recordings of heart rate variability in obsessive–compulsive disorder, panic disorder and healthy volunteers

Cited by 46 publications

References 40 publications

Heart rate variability as a measure of cardiac autonomic function in anorexia nervosa: A review of the literature

Heart rate variability as a measure of cardiac autonomic function in anorexia nervosa: A review of the literature

Anxiety Disorders are Associated with Reduced Heart Rate Variability: A Meta-Analysis

Cardiac stability at differing levels of temporal analysis in panic disorder, post‐traumatic stress disorder, and healthy controls

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