Five-membered ring systems: with more than one N atom

Intramolecular Nitrone Interrupted Click Reaction

“…The Cu-catalyzed azide alkyne cycloaddition leading to 1,2,3-triazole is one of this century’s innovations, the potential of which was rapidly uncovered . On one hand, the azide–alkyne cycloaddition has emerged as a versatile process for joining molecules together efficiently and selectively . On the other hand, due to the operational simplicity, regioselectivity, and reliability of this reaction, this 1,2,3-triazole scaffold has caught the attention of synthetic and medicinal chemists after quite a while.…”