Five-hour Oral Glucose Tolerance Test in Obese Children

Court, John M.; Dunlop, Marjorie; Leonard, Ingrid; Leonard, R. F.

doi:10.1136/adc.46.250.791

Cited by 5 publications

(5 citation statements)

References 17 publications

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“…The finding of some correlation between degree of obesity (judged by skinfold thickness measurements) and triglyceride values is compatible also with the proposition that large fat cells are related to metabolic disturbance associated with obesity (Bjorntorp and Sjostrom 1971). We have previously shown a significant correlation between glucose tolerance and fasting plasma glycerol values (Court et al, 1971) and have also found amongst this group an association between raised triglyceride values and abnormal glucose tolerance in all but the children whose obesity dated from infancy (unpublished data). This association of impaired glucose tolerance with raised triglyceride values was also documented in adults by Albrink and Meigs in 1964.…”

Section: Discussionsupporting

confidence: 83%

“…Harlan et al (1967) also related raised levels of triglyceride to acquired obesity and carbohydrate intolerance. This association of impaired glucose tolerance with raised triglyceride values was also documented in adults by Albrink and Meigs in 1964. We have previously shown a significant correlation between glucose tolerance and fasting plasma glycerol values (Court et al, 1971) and have also found amongst this group an association between raised triglyceride values and abnormal glucose tolerance in all but the children whose obesity dated from infancy (unpublished data).…”

Section: Discussionsupporting

confidence: 67%

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Plasma Lipid Values in Childhood Obesity

Court

Dunlop

Leonard

1974

J Paediatrics Child Health

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SYNOPSIS A study was made on 129 obese children to assess the relation of fasting plasma concentrations of cholesterol and triglyceride with clinical features of obesity. Mean values for both plasma cholesterol (195 mg/dl) and triglyceride (77 mg/dl) did not differ from those found in non‐obese children. Greater than expected numbers of children however were found with raised values of either cholesterol or triglyceride. Three children were found to have familial Type II hyperlipoproteinaemia, and eighteen were found to have a fasting triglyceride of greater than 120 mg/dl. No correlation was found between plasma cholesterol values and clinical features of obesity, but significant correlation was found between plasma triglyceride values and degree and duration of obesity, particularly amongst those children whose obesity started after the first year of life.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 67%

Plasma Lipid Values in Childhood Obesity

Court

Dunlop

Leonard

1974

J Paediatrics Child Health

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“…Data of mixed meal tolerance and OGTT data in children suggest a return to fasting glucose values after 120–180 min ( 27 ) and a peak glucose and insulin peak at 30 min ( 28 ). In insulin-resistant obese children, prolonged times (up to 240 min) have been observed ( 29 , 30 ), but data for very young children are missing. Our findings might suggest the possibility of differences in metabolism and insulin sensitivity throughout the day in 6-12-months-old infants, similar to observations in adults ( 31 , 32 ).…”

Section: Discussionmentioning

confidence: 99%

Glucose variability in 6–12-month-old healthy infants

et al. 2023

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BackgroundMetabolic programming of glucose homeostasis in the first 1,000 days of life may impact lifelong metabolic and cardiovascular health. Continuous glucose monitoring (CGM) devices may help measure the impact of dietary intake on glucose rhythms and metabolism in infants during the complementary feeding period.ObjectivesDemonstrate the feasibility of CGM to measure and quantify glucose variability in response to infant feeding and to evaluate associations between macronutrient meal composition and glucose variability.MethodsThe “FreeStyle Libre Pro®” device interstitial glucose meter was applied to the anterior thigh of 10 healthy 6–12-month-old infants. Parents recorded food intake, time of feeding, and used daily dairies to record sleep time and duration. Descriptive statistics were employed for food intake, sleep and key glycemic parameters over three full days. Mixed linear models were used to assess glycemic changes.ResultsMid-day, afternoon, and evening feeds contained >30 g carbohydrate and induced higher 2-h iAUC (3.42, 3.41, and 3.50 mmol/L*h respectively) compared to early and mid-morning feedings with ≤25 g carbohydrates (iAUC 2.72 and 2.81 mmol/L*h, p < 0.05). Early morning and evening milk feedings contained approximately 9 g of fat and induced a longer time to reach maximal glucose value (Tmax; 75 and 68 min, respectively) compared to lower fat feedings (2.9–5.9 g; Tmax range: 34–60 min; p < 0.05). Incremental glucose value at time of food intake (C0) increased significantly from 0.24 ± 0.39 mM in early morning to 1.07 ± 0.57 mM in the evening (p < 0.05). Over the day, 70% of glucose values remained within the normal range (3.5–5.5 mmol/L), 10% were between 5.5–10 mmol/L, and 20% were < 3.5 mmol/L.ConclusionOur data support the feasibility of using CGM to measure glucose in 6–12-month-old infants. The observation of possible diurnal glucose variability and typical glucose values may have implications for future studies investigating metabolic adaptation to nutritional intake in early life.

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“…Mit dem Abfall der adrenalen Hormonsynthese normalisiert sich das Wachstum (27,108 (24,69,81). Nach oraler Glukosebelastung sind die maximalen Glukosewerte erhöht (19,24,69) und in ca. 30 % besteht eine pathologische Glukosetoleranz.…”

Section: Adrenokortikotropes Hormon (Acl'h) Und Hormone Der Nebennierunclassified

“…Die Blutglukosewerte nach oraler Glukosebelastung kehren ca. 1-2 h später als bei normalgewichtigen Kindern zu ihrem Ausgangswert zurück (19,69). Weitere Untersuchungen geben Hinweise darauf; daß bei der Entstehung der Insulinresistenz auch ein gestörter intrazellulärer Glukosemetabolismus (Postrezeptordefekt) mitwirkt.…”

Section: Adrenokortikotropes Hormon (Acl'h) Und Hormone Der Nebennierunclassified

Hormonelle Befunde bei adipösen Kindern Übersicht

Rosskamp¹

1987

Klin Padiatr

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Serum thyroid hormones in childhood obesity are not altered but caloric intake affects monoiodination of T4 to T3 and rT3. Plasma cortisol and urinary free cortisol concentrations are normal. Increase in cortisol production and secretion rate is reflected in increased values of urinary 17-hydroxycorticosteroids. Elevated urinary 17-ketosteroids are caused by increased androgen synthesis accounting for the increased height velocity in obese preadolescents and for the accelerated skeletal maturation. In both sexes earlier onset of puberty is noticed without remarkable alterations in gonadal steroids. Whether altered prolactin concentrations reflect neuroendocrine abnormalities remains unclear. Impairment of growth hormone release in face of normal or high somatomedins is not of clinical significance. Basal and stimulated insulin concentrations are high. Insulin resistance exists because glucose tolerance is simultaneously impaired. This is due to reduction in insulin receptor numbers and post-receptor defects in insulin action. Weight loss is effective in normalizing the above mentioned hormonal defects.

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Five-hour Oral Glucose Tolerance Test in Obese Children

Cited by 5 publications

References 17 publications

Plasma Lipid Values in Childhood Obesity

Plasma Lipid Values in Childhood Obesity

Glucose variability in 6–12-month-old healthy infants

Hormonelle Befunde bei adipösen Kindern Übersicht

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