Five comorbidities reflected the health status in patients with chronic obstructive pulmonary disease: the newly developed COMCOLD index

Frei, Anja; Muggensturm, Patrick; Putcha, Nirupama; Siebeling, Lara; Zoller, Marco; Boyd, Cynthia M.; Riet, Gerben ter; Puhan, Milo A.

doi:10.1016/j.jclinepi.2014.03.005

Cited by 79 publications

(73 citation statements)

References 34 publications

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“…Their lower sensitivity in the population studies is in line with reports that disease-specific questionnaires are more sensitive in patients with COPD (47). Recently, the COMorbidities in Chronic Obstructive Lung Disease (COMCOLD) index has been developed, which includes PAD as one of the five most important comorbidities affecting patients' health status (48). The current study confirms these findings, as it demonstrates a clinically relevant association between PAD and disease-specific health status.…”

Section: Original Articlesupporting

confidence: 88%

Peripheral Artery Disease and Its Clinical Relevance in Patients with Chronic Obstructive Pulmonary Disease in the COPD and Systemic Consequences–Comorbidities Network Study

Houben-Wilke

Jörres

Bals

et al. 2017

Am J Respir Crit Care Med

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Rationale: Knowledge about the prevalence of objectively assessed peripheral artery disease (PAD) and its clinical relevance in patients with chronic obstructive pulmonary disease (COPD) is scarce.Objectives: We aimed to: (1) assess the prevalence of PAD in COPD compared with distinct control groups; and (2) study the association between PAD and functional capacity as well as health status.Methods: The ankle-brachial index was used to diagnose PAD (ankle-brachial index < 0.9). The 6-minute-walk distance, health status (St. George's Respiratory Questionnaire), COPD Assessment Test, and EuroQol-5-Dimensions were assessed in patients enrolled in the German COPD and Systemic Consequences-Comorbidities Network cohort study. Control groups were derived from the Study of Health in Pomerania. Conclusions: In a large cohort of patients with COPD, 8.8% were diagnosed with PAD, which is higher than the prevalence in control subjects without COPD. PAD was associated with a clinically relevant reduction in functional capacity and health status.

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Section: Original Articlesupporting

confidence: 88%

Peripheral Artery Disease and Its Clinical Relevance in Patients with Chronic Obstructive Pulmonary Disease in the COPD and Systemic Consequences–Comorbidities Network Study

Houben-Wilke

Jörres

Bals

et al. 2017

Am J Respir Crit Care Med

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“…and 16% of the patients with chronic heart failure had clinically relevant symptoms of anxiety [6]. Anxiety is one of the comorbidities with the largest negative impact on self-reported health status and is closely related to death [19,20]. Patients report that anxiety causes or increases breathlessness, but also that breathlessness results in anxiety.…”

Section: Key Pointsmentioning

confidence: 99%

Psychosocial consequences of living with breathlessness due to advanced disease

Janssen¹,

Wouters

Spruit³

2015

Current Opinion in Supportive &Amp; Palliative Care

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The consequences of living with breathlessness are multidimensional and arise in all aspects of daily life of patients, their family caregivers and their social environment. Multidimensional treatment programmes should become widely available to support patients with advanced disease and their family caregivers in coping with the functional, psychological and social consequences of living with breathlessness.

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“…First, the audit nature of the two convenient and large case series of patients hospitalised because of COPD exacerbation used for analysis [14][15][16][17] did not allow the active search of comorbidities [3], so we had to identify them by careful review of clinical records. This might contribute to explaining why 38% of the patients studied here did not apparently suffer any comorbidity, in contrast with previous studies [5,27,48]. Likewise, potentially relevant comorbidities not listed in the Charlson Comorbidity Index were not included in the analysis, nor was clinical severity.…”

Section: Strengths and Limitationsmentioning

confidence: 60%

Molecular and clinical diseasome of comorbidities in exacerbated COPD patients

et al. 2015

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The frequent occurrence of comorbidities in patients with chronic obstructive pulmonary disease (COPD) suggests that they may share pathobiological processes and/or risk factors.To explore these possibilities we compared the clinical diseasome and the molecular diseasome of 5447 COPD patients hospitalised because of an exacerbation of the disease. The clinical diseasome is a network representation of the relationships between diseases, in which diseases are connected if they co-occur more than expected at random; in the molecular diseasome, diseases are linked if they share associated genes or interaction between proteins.The results showed that about half of the disease pairs identified in the clinical diseasome had a biological counterpart in the molecular diseasome, particularly those related to inflammation and vascular tone regulation. Interestingly, the clinical diseasome of these patients appears independent of age, cumulative smoking exposure or severity of airflow limitation.These results support the existence of shared molecular mechanisms among comorbidities in COPD.@ERSpublications Half of the comorbidities observed in COPD patients hospitalised by an exacerbation share common molecular mechanisms

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Five comorbidities reflected the health status in patients with chronic obstructive pulmonary disease: the newly developed COMCOLD index

Abstract: The COMCOLD index reflects the combined impact of five important comorbidities from patients' perspective and complements existing comorbidity indices that predict death. It may help clinicians focus on comorbidities affecting patients' health status the most.

Cited by 79 publications

References 34 publications

Peripheral Artery Disease and Its Clinical Relevance in Patients with Chronic Obstructive Pulmonary Disease in the COPD and Systemic Consequences–Comorbidities Network Study

Peripheral Artery Disease and Its Clinical Relevance in Patients with Chronic Obstructive Pulmonary Disease in the COPD and Systemic Consequences–Comorbidities Network Study

Psychosocial consequences of living with breathlessness due to advanced disease

Molecular and clinical diseasome of comorbidities in exacerbated COPD patients

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