Abstract:Hereditary antithrombin deficiency (ATD) is a rare autosomal dominant condition (estimated prevalence 1:500–1:5000). Most ATD patients have AT activity levels 40–60% of normal. We present treatments for venous thromboembolism (VTE) in five cases of hereditary ATD. Four patients had a family history of ATD, and one had a
de novo
mutation. The majority of patients had a VTE while on prophylactic anticoagulation. AT concentrate augmentation was added in these cases to treat the VTE and for … Show more
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