Five Cases of Charcot–Marie–Tooth Disease With Positive COVID-19 Infection Reported Using Cerner Real-World Data™

Abstract

amplitudes of lower limbs with normal conduction velocities. Electromyography of lower limbs was normal.After 3 days of stabilization, clinical evolution was rapidly favorable without treatment.Three months after, residual sensory deficit was present in the feet.Six months after, there were no more symptoms.Diagnostic of pure acute sensory neuropathy associated with SARS-COV-2 disease was retained.This clinical case has been defined as a pure sensory GBS described like an acute monophasic widespread neuropathy characterized clinically by exclusive sensory symptoms progressing in a maximum of 6 weeks. 4 The association between SARS-COV-2 and sensory neuropathy seems obvious based on the time of appearance of neurological symptoms and positive SARS-COV-2 serology (7 days). All other causes of acute sensory neuropathy have been ruled out.The autoimmune nature was suggested by the presence of antiganglioside antibodies. Antibodies found in our patient (GM2 IgM and GD2 IgM) are not classically associated with GBS, but their presence has already been reported in association with sensitive neuropathies with good prognosis. 5 The existence of a pure sensory form of GB syndrome remains controversial, especially because in most cases, a clinical or electrophysiological motor component is found. Our presentation tends nevertheless to confirm existence of this form.