Fitting Nonlinear Calibration Curves: No Models Perfect

Martín, Julia; Gracia, A.; Asuero, Agustín G.

doi:10.4236/jasmi.2017.71001

Cited by 6 publications

(5 citation statements)

References 34 publications

(27 reference statements)

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“…This was largely due to the matrix effect of the samples, as we have noted before, attributed by the simple sample preparations (protein precipitation technique). This occurrence was noted in samples analyzed by LC-MS/MS in several other studies [15,20] and, hence, the option of quadratic regression is acceptable. The 1/x weighting factor was opted in the calibration curve in order to give more emphasis to the lower concentrations, as well as to ensure good assay performance.…”

Section: Lc-ms/ms Methods Validationmentioning

confidence: 71%

Liquid Chromatographic Tandem Mass Spectrometric (LC-MS/MS) Determination of Perfluorooctane Sulfonate (PFOS) and Perfluorooctanoic Acid (PFOA) in the Yolk of Poultry Eggs in Malaysia

2020

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Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) are widely used in products, and are known for their water and grease repellent properties. The persistence nature and potential toxicity of these substances have raised substantial concerns about health effects. Regarding humans, food consumption has reportedly been a significant source of exposure for both compounds. Hence, this study was performed to develop and validate an analytical method for PFOS and PFOA in egg yolks using liquid chromatographic tandem mass spectrometry (LC-MS/MS) followed by the determination of concentration of both compounds in the yolk of poultry eggs in Malaysia. A total of 47 poultry egg yolk samples were extracted by a simple protein precipitation technique using acetonitrile. The analytical method was developed using LC-MS/MS and validated based on the Food and Drug Administration (FDA)’s Bioanalytical Method Validation guidelines. The results revealed that PFOS was quantitatively detected in six samples, with the concentration range between 0.5 and 1.01 ng g−1. Among these, five samples were from home-produced chicken eggs, and one sample was from a quail egg. The levels of PFOA in all samples were below the quantifiable limit (<0.1 ng g−1). This indicated that the contamination of PFCs in poultry eggs were mostly attributed to the nature of free foraging animals, which had direct contact with the contaminants in soil and feed. In conclusion, a fast and robust analytical method for analyzing PFOS and PFOA in egg yolk samples using LC-MS/MS was successfully developed and validated. The presence of these emerging contaminants in this study signified widespread pollution in the environment.

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Section: Lc-ms/ms Methods Validationmentioning

confidence: 71%

Liquid Chromatographic Tandem Mass Spectrometric (LC-MS/MS) Determination of Perfluorooctane Sulfonate (PFOS) and Perfluorooctanoic Acid (PFOA) in the Yolk of Poultry Eggs in Malaysia

2020

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“…Secondly, non-linear calibration models are more complicated because many different polynomial equations have to be considered [16]. A quadratic model is J o u r n a l P r e -p r o o f frequently reported to fit calibration curves [21]. However, when a curvature is present, in some cases it is difficult to cope with a single quadratic regression that could be used over the entire range [22].…”

Section: Main Analytical Calibration Models Obtained By Lsr Methodsmentioning

confidence: 99%

Assessment of goodness-of-fit for the main analytical calibration models: Guidelines and case studies

Raposo

Barceló

2021

TrAC Trends in Analytical Chemistry

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“…Multiple reaction monitoring (MRM) scanning (precursor ion: 498.85 and product ion: 79.97) with electron spray ionization (ESI (−)) mode was adopted to quantitatively determine PFOS. A total of 10 calibration standards ranging from 0.01 to 10 mg L −1 were determined at the start of each measurement batch, and 3 calibration curves were established using standards 0.01-0.1 mg L −1 , 0.1-1 mg L −1 , and 1-10 mg L −1 , to satisfy the quantification of various PFOS concentration ranges (Figure 1) [34], with batch sample number ≤ 50 and R 2 ≥ 0.999 to ensure data quality. The electrokinetic porous media adsorption column reactor was designed according to Figure 2, the percolation column was design as described in our previous research [31].…”

Section: Determination Of Pfos Concentrationmentioning

confidence: 99%

Temperature–Electrokinetic Co-Driven Perfluorooctane Sulfonic Acid (PFOS) Adsorption on Geo-Adsorbents

Yin

Shan

et al. 2023

Processes

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Per- and polyfluoroalkyl substances (PFAS) have concerned the public due to their worldwide distribution and the threat they pose to drinking water safety and human health. Temperature and DC field-induced electroosmotic flow (EOF) are powerful tools to regulate organic contaminant adsorption and control PFOS (as a typical PFAS) transport in porous media. However, the co-driven mechanisms of temperature–electrokinetic transport of contaminants are still unclear. Here, we investigated the synergistic mechanisms of temperature–electrokinetic co-driven PFOS adsorption on zeolite and activated carbon as model geo-adsorbents. We found that DC fields increased PFOS adsorption on activated carbon by up to 19.8%, while they decreased PFOS adsorption on zeolite by up to 21.4%. Increasing the temperature decreased the adsorption of PFOS by activated carbon and zeolite. The temperature and electrokinetic synergistically drive EOF velocity to control PFOS adsorption. Synergistic mechanisms of temperature–electrokinetic regulated kinetic and temperature-regulated thermodynamic (the Gibbs free energy change ΔG) and kinetic (liquid viscosity) under various temperatures and DC field situations were analyzed with models. A kinetic approach interlinking viscosity, EOF velocity, and the kinetic adsorption constants was established to interpret the synergistic mechanisms which can be further adopted to estimate temperature–electrokinetic induced PFOS adsorption benefits to mineral and carbonaceous adsorbents. We concluded that such kinetic regulation may provide support for controlling the transmission of PFOS.

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Fitting Nonlinear Calibration Curves: No Models Perfect

Cited by 6 publications

References 34 publications

Liquid Chromatographic Tandem Mass Spectrometric (LC-MS/MS) Determination of Perfluorooctane Sulfonate (PFOS) and Perfluorooctanoic Acid (PFOA) in the Yolk of Poultry Eggs in Malaysia

Liquid Chromatographic Tandem Mass Spectrometric (LC-MS/MS) Determination of Perfluorooctane Sulfonate (PFOS) and Perfluorooctanoic Acid (PFOA) in the Yolk of Poultry Eggs in Malaysia

Assessment of goodness-of-fit for the main analytical calibration models: Guidelines and case studies

Temperature–Electrokinetic Co-Driven Perfluorooctane Sulfonic Acid (PFOS) Adsorption on Geo-Adsorbents

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