Fitness adaptations of Japanese encephalitis virus in pigs following vector-free serial passaging
Andrea Marti,
Alexander Nater,
Jenny Pego Magalhaes
et al.
Abstract:Japanese encephalitis virus (JEV) is a zoonotic mosquito-transmitted Flavivirus circulating in birds and pigs. In humans, JEV can cause severe viral encephalitis with high mortality. Considering that vector-free direct virus transmission was observed in pigs, JEV introduction into an immunologically naïve pig population could result in a series of direct transmissions disrupting the alternating host cycling between vertebrates and mosquitoes. To assess the potential consequences of such a realistic scenario, w… Show more
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