Fistula following total laryngectomy. Retrospective study and bibliographical review

Pharyngocutaneous fistula after total laryngectomy: Systematic review of risk factors

“…Patients with positive margins presented an increase in the risk for PCF of 8% (IC 95% 0.02–0.14; p = .01 and I 2 = 66%). A similar result was obtained after excluding the studies responsible for higher heterogeneity (16%; IC 95% 0.08–0.24; p < .001 and I 2 = 6%).…”

“…After evaluating their titles and abstracts, 248 studies were excluded because they clearly did not fill the inclusion criteria. The findings of this review were based on the data of 63 primary studies . The results are summarized in Table .…”

“…Twelve articles also evaluated the surgical margins as a risk factor. Patients with positive margins presented an increase in the risk for PCF of 8% (IC 95% 0.02–0.14; p = .01 and I 2 = 66%).…”

Clinical application of decellularized and lyophilized human amnion/chorion membrane grafts for closing post‐laryngectomy pharyngocutaneous fistulas

“…Pharyngocutaneous fistula (PCF) is the most frequent major complication of those mentioned above. Rates of PCF between 8.5% and 24% have been most frequently reported [14][15][16][17][18][19][20][21][22][23]. Factors associated with the occurrence of PCF are stage of cancer, extent of resection, the use of preoperative radiation treatment in doses at or exceeding 50 Gy, and the method of repair of the pharyngeal defect [12,24].…”

Fatores preditores de fístula salivar pós-laringectomia total

“…Regarding the treatment of salivary fistula, there is a consensus that, initially, it should be conservative (antibiotics and dressing), as fistulas close spontaneously in most cases 4,14,15 . Surgical treatment is reserved for cases of failure of the clinical treatment 14 .…”