Fission product 99mTc generator

Arino, Hirofumi; Kramer, H.H.

doi:10.1016/0020-708x(75)90165-9

Cited by 53 publications

(14 citation statements)

References 2 publications

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“…Increased disordering and hydration (i.e., increased dispersion stability) accounted for the high pH. However, the shape of the adsorption curve onto in-situ precipitated alumina polymers is more or less similar to Mo(VI) adsorption envelopes onto suspensions of solid gibbsite and amorphous Al oxide from NaCl solutions, Mo(VI) uptake onto in-situ precipitated boehmite is very high [5,28,41]. Figure 3 (curve b) shows that, except for the two terminal adsorption % of 99 Mo at pH 9.5 and 4.5, a straight line similar to anion exchange reactions with negative slope value of ∼ 0.313 was obtained.…”

Section: Infrared Spectra Of the Alumina Polymermentioning

confidence: 92%

“…The AlMo gel, prepared at pH 5.5 from NO 3 − solution, has reproducible 99m Tc, elution performance not seriously affected by small fractional changes in the preparation pH value as ZrMo gels [4,17,19,20]. Separation and Q.C indices of 99m Tc radionuclide generated from the alumina 99 Mo-molybdate(VI) matrix at pH 5.5 are as high as these from 99 Mo/ 99m Tc generators based on Al 2 O 3 loaded fission 99 Mo [3][4][5] Reproducibility of the preparation process and 99m Tc elution performance were investigated 8 times using 5-10 mCi. 99 Mo/ 99m Tc generators eluted over 12 d from the preparation date at the frequencies of 1,2 and 3 d between two successive elutions.…”

Section: Elution Performance Of 99m Tc Radionuclidementioning

confidence: 99%

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Synthesis of alumina ⁹⁹Mo-molybdate(VI) gel matrices and evaluation of ^99mTc elution performance

et al. 2014

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Synthesis of a novel alumina 99 Momolybdate(VI) gel matrix of high Mo(VI) content and reproducible separation indices of the generated 99m Tc radionuclde are described and briefly discussed. Similar mixture solutes of aluminate and low specific activity 99 Mo-molybdate(VI) anions in concentrated NaOH are prepared. Then, the solutes are acidified with concentrated HCl, HNO 3 and/or H 2 SO 4 at pH 9.5-4.5. Physicochemical investigations indicate that molybdate(VI) anions are strongly adsorbed onto in situ-precipitated pseudoboehmite from acidic solutions than from basic solutions. The maximum adsorption % of 99 Mo (167 mg Mo/g matrix dried at 50 ∘ C) is achieved from the nitrate solution at pH 5.5. Separation of 99m Tc from the corresponding gel matrix with physiological saline solution exhibits high elution yield with a narrow elution profile and radionuclidic, radiochemical and chemical purity indices comparable with 99m Tc eluates from 99 Mo/ 99m Tc generators prepared by loading alumina with fission 99 Mo.

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Section: Infrared Spectra Of the Alumina Polymermentioning

confidence: 92%

Section: Elution Performance Of 99m Tc Radionuclidementioning

confidence: 99%

Synthesis of alumina ⁹⁹Mo-molybdate(VI) gel matrices and evaluation of ^99mTc elution performance

et al. 2014

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“…Technetium-99m is mainly supplied from 99 Mo/ 99m Tc chromatographic column generators based on alumina loaded with fission-99 Mo (with a loading capacity of 2 mg Mo/g at pH 5-6.2) [3]. In addition, hydrous zirconium oxide, hydrous titanium oxide, manganese dioxide, silica gel and hydrotalcites have also been investigated as base column beds for fission 99 Mo/ 99m Tc generators [4].…”

Section: Introductionmentioning

confidence: 99%

Preparation and performance of ⁹⁹Mo/^99mTc chromatographic column generator based on zirconium molybdosilicate

et al. 2015

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Zirconium molybdosilicate (ZrMoSi) gel prepared using 99 Mo radiotracer via peroxo route was used as a base material for 99 Mo/ 99m Tc column generator. The 99m Tc elution yield and 99 Mo breakthrough in the eluate were studied as a function of the pH-value of gel precipitation, gel drying temperature and Zr : Mo : Si molar ratio. Precipitation pH-value of 2, drying temperature of 100 ∘ C and Zr : Mo : Si molar ratio of 0.5 : 0.5 : 1 were found to be the optimum conditions achieving 99m Tc elution yield of 82% and 99 Mo breakthrough of 1.0 × 10 −3 %.The gel prepared with the optimum conditions was characterized by BET surface area and pore size analyzer, IR spectroscopy, thermal analysis (TGA and DTA), XRD, XRF and FESEM. Technetium-99m eluted from the optimum ZrMoSi 99 Mo/ 99m Tc generator was found to have a high radiochemical purity (98% as 99m TcO − 4 ) and chemical purity meeting criteria of clinical grade.

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“…2− and Mo 7 O 24 6− ) in diluted HNO 3 (pH = 3.0 ± 0.5) [22,23], which is widely used in production of 99 Mo/ 99m Tcgenerators. However, no data about the behavior of Nb on alumina column, or about the behavior of Mo or Nb on alumina column in HF medium have been reported.…”

Section: Introductionmentioning

confidence: 99%

Preparation of 93Mo solution using proton irradiated Nb

Osváth

Qiao

Hou

2019

J Radioanal Nucl Chem

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93 Mo is an important long-lived radionuclide in nuclear waste, and is required to be measured during the characterization of decommissioning waste. However, no commercial 93 Mo solution is available to be calibrated and used as standard in the analysis of nuclear waste. This work presents a method for separation of 93 Mo from Nb metal used in cyclotron as a target holder and irradiated with protons for long time. The separation of 93 Mo from Nb matrix was implemented by combination of precipitation and chromatographic separation. The Nb matrix was first removed by precipitating oxides-hydroxides of Nb (e.g. Nb 2 O 5) and then by Fe(OH) 3 co-precipitation; Mo in the solution was purified using an alumina (Al 2 O 3) column. A decontamination factor of ca. 10 5 was achieved for Nb. A pure carrier-free 93 Mo solution was successfully prepared, and the 93 Mo purity was verified by liquid scintillation spectrometry. Keywords 93 Mo • Nb • Separation • Nb 2 O 5 /Fe(OH) 3 precipitation • Alumina (Al 2 O 3) column • LSC

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Fission product 99mTc generator

Cited by 53 publications

References 2 publications

Synthesis of alumina ⁹⁹Mo-molybdate(VI) gel matrices and evaluation of ^99mTc elution performance

Synthesis of alumina ⁹⁹Mo-molybdate(VI) gel matrices and evaluation of ^99mTc elution performance

Preparation and performance of ⁹⁹Mo/^99mTc chromatographic column generator based on zirconium molybdosilicate

Preparation of 93Mo solution using proton irradiated Nb

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Fission product 99mTc generator

Cited by 53 publications

References 2 publications

Synthesis of alumina 99Mo-molybdate(VI) gel matrices and evaluation of 99mTc elution performance

Synthesis of alumina 99Mo-molybdate(VI) gel matrices and evaluation of 99mTc elution performance

Preparation and performance of 99Mo/99mTc chromatographic column generator based on zirconium molybdosilicate

Preparation of 93Mo solution using proton irradiated Nb

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Synthesis of alumina ⁹⁹Mo-molybdate(VI) gel matrices and evaluation of ^99mTc elution performance

Synthesis of alumina ⁹⁹Mo-molybdate(VI) gel matrices and evaluation of ^99mTc elution performance

Preparation and performance of ⁹⁹Mo/^99mTc chromatographic column generator based on zirconium molybdosilicate