Fishing for Links Between Omega-3 Fatty Acids and Atrial Fibrillation

Fatkin, Diane; Cox, Charles D.; Martinac, Boris

doi:10.1161/circulationaha.121.058596

Cited by 13 publications

(12 citation statements)

References 7 publications

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“…The mechanisms underlying the increased AF risk from marine omega-3 fatty acid supplements are unknown, but several hypotheses have been proposed. Upon ingestion omega-3 fatty acids may become incorporated into membranes of cardiomyocytes and affect membrane properties and ion channels, ionic pumps and receptors, which may influence atrial arrhythmogenesis [4 ▪▪ ]. Interestingly, marine omega-3 fatty acids have recently been proposed to enhance atrial arrhythmogenesis through modulation of PIEZO1/2 ion channel activity [4 ▪▪ ].…”

Section: Discussionmentioning

confidence: 99%

“…Upon ingestion omega-3 fatty acids may become incorporated into membranes of cardiomyocytes and affect membrane properties and ion channels, ionic pumps and receptors, which may influence atrial arrhythmogenesis [4 ▪▪ ]. Interestingly, marine omega-3 fatty acids have recently been proposed to enhance atrial arrhythmogenesis through modulation of PIEZO1/2 ion channel activity [4 ▪▪ ]. Also, increased vagal tone mediated by marine omega-3 fatty acids could predispose to AF, but on the other hand, marine omega-3 fatty acids have been suggested to prevent atrial remodeling by decreasing atrial enlargement and limiting atrial fibrosis and hypertrophy, which might reduce the risk of AF.…”

Section: Discussionmentioning

confidence: 99%

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Do omega-3 fatty acids increase risk of atrial fibrillation?

Bork

Myhre

Schmidt

2022

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of the reviewTo summarize the findings from recent observational follow-up studies and randomized trials of plant- and marine omega-3 fatty acids on the risk of atrial fibrillation (AF).Recent findingsRecent randomized cardiovascular outcome trials have indicated that supplements with marine omega-3 fatty acids may be associated with a higher risk of AF, and a meta-analysis has suggested that marine omega-3 fatty acid supplements were associated with a 25% higher relative risk of AF. Also, a recent large observational study reported a modest higher risk of AF in habitual users of marine omega-3 fatty acid supplements. However, recent observational biomarker studies of circulating and adipose tissue content of marine omega-3 fatty acids have in contrast reported a lower risk of AF. Very limited knowledge exists on the role of plant-derived omega-3 fatty acids and AF.SummaryMarine omega-3 fatty acid supplements may increase the risk of AF, whereas biomarkers reflecting consumption of marine omega-3 fatty acids have been linked to a lower risk of AF. Clinicians should inform patients that marine omega-3 fatty acid supplement may increase AF risk, and this should be taking into account when discussing pros and cons of taking supplements with marine omega-3 fatty acids.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Do omega-3 fatty acids increase risk of atrial fibrillation?

Bork

Myhre

Schmidt

2022

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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“…Thus, individual trials and meta-analyses of mostly recent trials indicate that long-chain omega-3 PUFAs increase the risk of AF, especially when used at high doses. A recent commentary has argued that the effect of long-chain omega-3 fatty acids on AF is "U-shaped": they reduce risk of AF at moderate doses but increase risk at high doses (102). This is obviously a concern, although it is interesting to note that REDUCE-IT, while reporting increased risk of AF, also reported reduced risk of a range of hard cardiovascular outcomes.…”

Section: Long-chain Omega-3 Fatty Acids and Atrial Fibrillationmentioning

confidence: 99%

Pros and Cons of Long-Chain Omega-3 Polyunsaturated Fatty Acids in Cardiovascular Health

Djuričić

Calder

2023

Annu. Rev. Pharmacol. Toxicol.

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The long-chain omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are found in seafood, supplements, and concentrated pharmaceutical preparations. Prospective cohort studies demonstrate an association between higher intakes of EPA+DHA or higher levels of EPA and DHA in the body and lower risk of developing cardiovascular disease (CVD), especially coronary heart disease and myocardial infarction, and of cardiovascular mortality in the general population. The cardioprotective effect of EPA and DHA is due to the beneficial modulation of a number of risk factors for CVD. Some large trials support the use of EPA+DHA (or EPA alone) in high-risk patients, although the evidence is inconsistent. This review presents key studies of EPA and DHA in the primary and secondary prevention of CVD, briefly describes potential mechanisms of action, and discusses recently published RCTs and meta-analyses. Potential adverse aspects of long-chain omega-3 fatty acids in relation to CVD are discussed.

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“…Recently, some studies have found that PIEZO proteins mediate the effect of omega-3 fatty acids on AF [28]. The PIEZO1/2 proteins are two of the largest ion channels discovered to date, with over 2,500 amino acids arranged in 38 transmembrane helices.…”

Section: Possible Mechanisms Underlying the Association Between Omega...mentioning

confidence: 99%

Omega-3 fatty acids and atrial fibrillation

Huh

2023

Korean J Intern Med

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Although some clinical trials have demonstrated reduced incidence of cardiovascular disease with the use of omega-3 fatty acids, others have found an increased risk of atrial fibrillation (AF). AF is the most common sustained cardiac arrhythmia worldwide. It is associated with high morbidity and mortality rates and significant public health burden. Previous studies of the effect of omega-3 fatty acids on AF occurrence have reported contradictory results. Here we reviewed the effect of omega-3 fatty acids on the risk of AF.

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Fishing for Links Between Omega-3 Fatty Acids and Atrial Fibrillation

Cited by 13 publications

References 7 publications

Do omega-3 fatty acids increase risk of atrial fibrillation?

Do omega-3 fatty acids increase risk of atrial fibrillation?

Pros and Cons of Long-Chain Omega-3 Polyunsaturated Fatty Acids in Cardiovascular Health

Omega-3 fatty acids and atrial fibrillation

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