Fisher’s Syndrome Associated with <i>Campylobacter jejuni </i>Infection

Abstract

A patient developed typical features of Fisher’s syndrome after an infection with Campylobacter jejuni as ascertained by positive serology both in the blood and spinal fluid. This may be the first case of this association described.

Treatment of the Guillain-Barré Syndrome

“…The pathogenesis of GBS after CJC infection is not clear. No special serotype of CJC has been linked to GBS, and a GBS variant such as the Fisher syndrome has also been described following CJC infection [91]. Furthermore, GBS has occasionally been described after other enteric infections such as Yersinia [44] and Salmonella [155].…”

Management of children with Guillain-Barre syndrome

“…Poliovirus infection is not a cause 19 . Campylobacter jejuni infection often with diarrhoea is the most common identifiable infectious precedent of GBS, particularly with the Miller-Fisher variant 15 20 – 25. Mycoplasma pneumoniae also remains an important antecedent infection responsible for GBS 26 – 29.…”

Miller-Fisher syndrome associated with Campylobacter jejuni bearing lipopolysaccharide molecules that mimic human ganglioside GD3

“…Miller-Fisher syndrome (MFS) is a neuropathy associated with ataxia, areflexia, and ophthalmoplegia and is considered to be an infrequent variation of the more common form known as Guillain-Barré syndrome (GBS) (19). Renewed interest in the etiology of these neuropathies has stemmed from the findings that the onset of both MFS and GBS in some patients is preceded by intestinal infections with Campylobacter jejuni (10,12,18,20,24,25). Kuroki et al (11) reported in a study of 11 GBS patients that 7 of the 8 who were cultured were positive for C. jejuni and that 5 of the 7 experienced abdominal pain or diarrhea or both 5 to 15 days before onset of GBS symptoms.…”