Fisher's Exact and Barnard's Tests

Andrés, Antonio Martín

doi:10.1002/0471667196.ess0642.pub2

Cited by 2 publications

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“…The independence test in 2 × 2 tables has a long, controversial and complicated history (Martín Andrés, 1998; Martín Andrés, Herranz Tejedor, & Gayá Moreno, 2020), and this applies both to the exact test and the asymptotic test. In both cases, the test to be used depends on whether or not the researcher is in favor of the conditional method (Fisher, 1935) or the unconditional method (Barnard, 1947).…”

Section: Introductionmentioning

confidence: 99%

The Yates, Conover, and Mantel statistics in 2 × 2 tables revisited (and extended)

Martín Andrés,

Hernández,

Gayá Moreno

2023

Statistica Neerlandica

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Asymptotic inferences about the difference, ratio or odds‐ratio of two independent proportions are very common in diverse fields. This article defines for each parameter eight conditional inference methods. These methods depend on: (1) using a chi‐squared type statistic or a z type one; (2) using the classic Yates continuity correction or the less well‐known Conover one; and (3) whether the p‐value of the test is determined by doubling the one‐tailed p‐value or by the Mantel method (asymmetrical approach). In all cases, the conclusions are: (i) the methods based on the chi‐squared statistic should not be used, as they are too liberal; (ii) for those in favour of using the criterion of doubling the p‐value, the best method is using the z statistic with Conover continuity correction; and (iii) for those in favour of the asymmetrical approach, the best method is based on the z statistic with Conover continuity correction and the Mantel p‐value.This article is protected by copyright. All rights reserved.

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Section: Introductionmentioning

confidence: 99%

The Yates, Conover, and Mantel statistics in 2 × 2 tables revisited (and extended)

Martín Andrés,

Hernández,

Gayá Moreno

2023

Statistica Neerlandica

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Analysis of SOD1 and C9orf72 mutations in patients with amyotrophic lateral sclerosis in Antioquia, Colombia

et al. 2022

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Introduction: Amyotrophic lateral sclerosis is a neurodegenerative disease with a possible multifactorial origin characterized by the progressive degeneration of motor neurons. There is a relatively high prevalence of this disease in Antioquia; however, there is no published genetic study to date in Colombia. Despite its unknown etiopathogenesis, more genetic risk factors possibly involved in the development of this disease are constantly found.Objetives: To evaluate G93A and D90A mutations in SOD1 gene and a short tandem repeat in C9orf72 within a cohort of amyotrophic lateral sclerosis patients from Antioquia, Colombia.Materials y methods: Thirty-four patients previously diagnosed with amyotrophic lateral sclerosis were included in the study. Peripheral blood samples were used for DNA extraction and genotyping.Results: No mutations were found in SOD1 (G93A and D90A) in any of the patients, while C9orf72 exhibited an allele with a statistically significant high prevalence in the study sample (8 hexanucleotide repeats of CAGCAG).Conclusions: These results suggest an association between this short tandem repeat (STR) in C9orf72 and the presence of amyotrophic lateral sclerosis in the studied population. However, this association should be established in a larger sample size and with controls from the same population. In addition, there also seems to be a genetic anticipation effect for the disease regarding this locus, since patients with this genotype present an earlier onset.

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Fisher's Exact and Barnard's Tests

Cited by 2 publications

References 80 publications

The Yates, Conover, and Mantel statistics in 2 × 2 tables revisited (and extended)

The Yates, Conover, and Mantel statistics in 2 × 2 tables revisited (and extended)

Analysis of SOD1 and C9orf72 mutations in patients with amyotrophic lateral sclerosis in Antioquia, Colombia

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