Fish Zona Radiata (Eggshell) Protein: A Sensitive Biomarker for Environmental Estrogens

Arukwe, Augustine; Knudsen, Frank Reier; Goksøyr, Anders

doi:10.2307/3433339

Cited by 46 publications

(68 citation statements)

References 19 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, to use ZP proteins as biomonitor appear to have a higher potential than vitellogenin because, while subtle changes in VTg would not be a threat to the survival of the offspring, small changes in ZP expression or synthesis might cause differences in thickness and strength of the egg envelope. The consequences of these alterations could affect fertilization and polyspermy prevention and protection of the embryo during development (Arukwe et al, 1997;Arukwe and Goksøyr, 2003).…”

Section: Biomonitor Valuementioning

confidence: 99%

See 1 more Smart Citation

Gamete interactions in teleost fish: the egg envelope. Basic studies and perspectives as environmental biomonitor

2011

View full text Add to dashboard Cite

The current knowledge about teleost fi sh egg envelope is summarized. The paper analyzes the organization and deposition process of the protein composition and genes involved in the synthesis of teleost fi sh egg envelopes and their role in gamete interaction during fertilization. Pelagic and demersal species that our research group is working with are especially considered. The vertebrate ZP family of proteins, the evolution and relationship among the different genes and their expression are taken into account. We consider fi sh envelope as a possible biomonitor for ecological contaminants. The biotechnological applications for aquaculture and genomic and post-genomic approaches are auspicious.

show abstract

Section: Biomonitor Valuementioning

confidence: 99%

“…Changes in ZP synthesis and organization of egg envelopes have been reported in both kind of oocyte envelope (pelagic and demersal) as a consequence of aquatic contaminants (especially xenoestrogens) (Arukwe et al, 1997;Arukwe and Goksøyr, 2003).…”

Section: Introductionmentioning

confidence: 99%

Gamete interactions in teleost fish: the egg envelope. Basic studies and perspectives as environmental biomonitor

2011

View full text Add to dashboard Cite

show abstract

“…In 1991, Soto et al 24) reported estrogenicity for nonylphenol released from plastic tubes. The compound has been implicated in the disruption of endocrine functions in wildlife, [25][26][27][28] but despite its estrogenic activity, there have been only a limited number of reports concerning effects on carcinogenesis in vivo. [29][30][31] Whether it might influence neoplasia of the breast is of particular interest.…”

mentioning

confidence: 99%

Possible enhancing effects of atrazine and nonylphenol on 7,12‐dimethylbenz[a]anthracene‐induced mammary tumor development in human c‐Ha‐ras proto‐oncogene transgenic rats

Fukamachi¹,

Han

Kim

et al. 2004

Cancer Science

View full text Add to dashboard Cite

Our transgenic (Tg) strain carrying copies of the human c-Ha-ras proto-oncogene is highly susceptible to 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis, possibly due to activation of the transgene, and can be used in medium-term bioassay models to test for modifying effects of estrogenic environmental compounds on tumor development. The present study was conducted to assess the influence of dietary feeding of the endocrine disruptors atrazine and nonylphenol on DMBA-induced carcinogenesis in c-Ha-ras Tg rats. Animals of both sexes were given a single oral dose of DMBA (25 mg/kg body weight) at 50 days of age and thereafter received soybean-free diet containing 5, 50 or 500 ppm atrazine, or 10, 25, 100 or 250 ppm nonylphenol. In female Tg rats, atrazine at a dose of 5 ppm increased the incidences of mammary adenomas and adenocarcinomas (P < < < <0.01 and P < < < <0.05), while 50 ppm increased the adenocarcinoma incidence (P < < < <0.05). In males, skin tumor development, in contrast, was significantly decreased at the highest dose. Nonylphenol at 10 ppm increased adenocarcinoma and total mammary tumor multiplicity in female Tg rats (P < < < <0.05), but there was no dose dependence, a significant quadratic dose-response trend rather being observed (P < < < <0.05). In vitro, atrazine did not cause proliferation of MCF-7 cells at any of a range of doses tested. These results suggest that endocrine disruptors may enhance mammary carcinogenesis, but only in a certain limited dose range under the present experimental conditions. The doses applied, moreover, were all extremely high compared to the possible environmental human exposure levels. (Cancer Sci 2004; 95: 404-410) t is well documented that estrogen is an obligatory factor for development of the mammary gland.1, 2) The hormone also plays an important role in both the etiology and treatment of mammary cancer and accumulating evidence indicates that slightly elevated levels of circulating estrogens may predispose to tumorigenesis.3, 4) Exogenous estrogens may similarly increase mammary cancer risk.5-7) This may be of considerable importance, since recently, a number of environmental chemicals impacting on the endocrine system (endocrine disruptors) have been shown to exhibit estrogenic activity, these including triazine derivatives and alkylphenolic compounds.Among the symmetrical triazine-type herbicides, atrazine (6-chloro-N 2 -ethyl-N 4 -isopropyl-1,3,5-triazine-2,4-diamine) is one of the most widely and heavily used herbicides all over the world. It is employed in agriculture as a selective pre-and postemergence agent for annual control of grass and broad-leaved weeds. A number of studies have suggested that atrazine is an endocrine disruptor [8][9][10][11][12][13][14][15] and in female Sprague-Dawley, but not other strains of rats, high doses (50-1000 ppm) in the diet have been found to be associated with an increased incidence and/or an earlier onset of mammary gland tumors. [16][17][18][19][20] Alkylphenol polyethoxylates are the se...

show abstract

“…The refinery wastewater streams are mainly from four different sources: the process systems; the SO 2 sea-water scrubber; sewage; and unpolluted wastewater (rainwater), which can be highly contaminated with both free and floating oil as well as emulsified oil, some phenols and polyaromatic hydrocarbons that can have dangerous implications for marine life when released to the environment (Arukwe et al, 1997;Siljeholm, 1998). In addition, the wastewater contains significant quantities of sulphur compounds, mostly in the form of ionised sulphides, and is also typically contaminated with appreciable quantities of ammonia from nitrogenous compounds present in the feedstock.…”

Section: Waste Streamsmentioning

confidence: 99%

An oil refinery in the North Atlantic: environmental profile

Sólnes

2000

Impact Assessment and Project Appraisal

View full text Add to dashboard Cite

Fish Zona Radiata (Eggshell) Protein: A Sensitive Biomarker for Environmental Estrogens

Cited by 46 publications

References 19 publications

Gamete interactions in teleost fish: the egg envelope. Basic studies and perspectives as environmental biomonitor

Gamete interactions in teleost fish: the egg envelope. Basic studies and perspectives as environmental biomonitor

Possible enhancing effects of atrazine and nonylphenol on 7,12‐dimethylbenz[a]anthracene‐induced mammary tumor development in human c‐Ha‐ras proto‐oncogene transgenic rats

An oil refinery in the North Atlantic: environmental profile

Contact Info

Product

Resources

About