Fish Oil With Essence of Chicken Decreases Serum and Hepatic Triacylglycerol in Hamsters Fed an Atherogenic Diet

Abstract

The aim of the present study was to investigate the effect of a mixture of dietary chicken essence and fish oil on possible lowering of blood and hepatic lipids in hamsters. Forty male hamsters were randomly divided into four groups and fed a chow diet, high fat/cholesterol diet (HFC), HFC diets containing 4% (HFC4) or 8% (HFC8) fish oil with essence of chicken for 42 days. The experimental diets contained 10% (w/w} fat. Hamsters fed HFC diets containing either 4 or 8% fish oil with essence of chicken showed significantly decreased serum triacylglycerols (TG} compared to hamsters fed HFC diets. In addition, hamsters fed HFC8 diets exhibited significantly reduced hepatic TG than those fed HFC diet. However, hamsters fed HFC4 or HFC8 diets significantly increased low density lipoprotein cholesterol (LDL-C) and decreased high density lipoprotein cholesterol (HDL-C) when compared with those on HFC diet. These results suggest that 4% (or more} fish oil with essence of chicken might significantly lower serum TG and hepatic TG in hamsters, but seem to increase serum cholesterol levels on HFC diets.