Fish Oil Supplementation Reduces Heart Levels of Interleukin-6 in Rats with Chronic Inflammation due to Epilepsy

Abstract

Sudden unexpected death in epilepsy (SUDEP) is a major cause of premature death related to epilepsy. The causes of SUDEP remain unknown, but cardiac arrhythmias and asphyxia have been suggested as a major mechanism of this event. Inflammation has been implicated in the pathogenesis of both epilepsy and ventricular arrhythmia, with interleukin-6 (IL-6) being recognized as a crucial orchestrator of inflammatory states. Our group previously reported that levels of IL-6 were increased in the hearts of epileptic rats. In this scenario, anti-inflammatory actions are among the beneficial effects of fish oil dietary supplementation. This investigation revealed that elevated levels of IL-6 in the heart were markedly reduced in epileptic rats that were treated in the long-term with fish oil, suggesting protective anti-inflammatory actions against dangerously high levels of IL-6. Based on these findings, our results suggest beneficial effects of long-term intake of fish oil in reducing the inflammation associated with chronic epilepsy.

Burden of Arrhythmias in Epilepsy Patients: A Nationwide Inpatient Analysis of 1.4 Million Hospitalizations in the United States

“…In the case of arrhythmia, the exact etiology is still unknown. Authors have suggested different theories like inflammation by Interleukin-6 (IL-6), autonomic dysregulations or altered ion channel due to drug resistant epilepsy [ 2 , 4 , 19 ]. The patients suffering from temporal lobe epilepsy are seen to be at increased risk of post-ictal arrhythmia due to autonomic instability.…”

Нейровоспаление И Эпилептогенез (Обзор Литературы)

“…Также ИЛ-6 вносит свой вклад в эпилептогенез посредством снижения активности рецепторов класса ГАМК-А, необходимых для поступления Cl -, оказывающего противосудорожный эффект [1]. Гипотеза о проэпилептогенном эффекте ИЛ-6 была подтверждена в ряде работ с животными моделями эпилепсии [14,26]. В случае же изучения связи ИЛ-6 и эпилепсии нет однозначного мнения.…”

Effect of Fish Oil on Heart Health: A Meta-Analysis

“…However, there have been ongoing debates about whether fish oil is actually beneficial to the heart [9]. Many studies have been conducted, including observational studies or randomized clinical trials, to test for association between intake of fish oil or other forms of omega-3 fatty acids supplements and cardiovascular outcomes, and the results are mixed [10][11][12][13][14][15]. The inconsistency of results may be due to difference in target populations, such as healthy vs high-risk population, limitation on sample size, amount of intake, and choice of outcomes.…”