Fish Oil Supplementation Lowers C‐Reactive Protein Levels Independent of Triglyceride Reduction in Patients With End‐Stage Renal Disease

Bowden, Rodney G.; Wilson, Ronald L.; Deike, E; Gentile, Mindy

doi:10.1177/0884533609335376

Cited by 61 publications

(52 citation statements)

References 29 publications

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“…22 In addition, fish-oil supplementation lowered CRP levels in patients with end-stage renal disease. 23 Although our findings do not firmly establish a causative association, the temporal sequence of these effects suggests that ω-3 PUFAs may have attenuated the inflammatory response in a manner that minimizes tissue injury while avoiding suppression of those components of inflammation necessary for subsequent wound healing. Dampening the magnitude of the inflammatory response might facilitate resolution of inflammation and transition to wound healing.…”

Section: Outcome Datacontrasting

confidence: 69%

Impact of a Nutritional Formula Enriched in Fish Oil and Micronutrients on Pressure Ulcers in Critical Care Patients

Theilla¹,

Schwartz²,

Cohen³

et al. 2012

American Journal of Critical Care

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Background Pressure ulcers are an important source of morbidity and suffering for patients and a formidable burden on caregivers. Objectives To assess the impact of a feeding formula enriched with fish oil on healing of preexisting pressure ulcers and serum levels of C-reactive protein in critical care patients. Methods Adult patients with pressure ulcers grade II or higher were randomly allocated to receive either a formula enriched with fish oil or an isocaloric control formula. Wound healing was assessed by using the Pressure Ulcer Scale for Healing tool on days 7, 14, and 28. Blood levels of C-reactive protein were measured on days 0, 7, and 14. Results Baseline demographics did not differ between the study (n = 20) and the control (n = 20) groups. The mean score on the ulcer healing tool increased significantly (P = .02) from day 0 to day 28 in the control group (from 9.25 [SD, 2.12] to 10.75 [SD, 3.41]) compared with the study group (from 9.10 [SD, 2.84] to 9.40 [SD, 3.72]). Mean levels of C-reactive protein decreased significantly (P = .02) from day 0 to day 14 in the study group (from 191 [SD, 104.4] mg/L to 111.7 [SD, 97.8] mg/L) compared with the control group (from 145 [SD, 90] mg/L to 139 [SD, 62] mg/L). Conclusion Administration of a feeding formula enriched with fish oil was associated with decreased progression of pressure ulcers and a decrease in blood concentrations of C-reactive protein.

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Section: Outcome Datacontrasting

confidence: 69%

Impact of a Nutritional Formula Enriched in Fish Oil and Micronutrients on Pressure Ulcers in Critical Care Patients

Theilla¹,

Schwartz²,

Cohen³

et al. 2012

American Journal of Critical Care

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“…Another hypothesis for the cardioprotective effects of fish oil supplementation is the inhibition of cytokine production, as measured directly in plasma or ex vivo, and studies have been published that support and challenge the hypothesis that n-3 LCP inhibit cytokine and CRP production (102,103,(140)(141)(142)(143)(144)(145)(146)(147)(148)(149)(150) . In their recent meta-analysis including twenty-one trials, Balk et al (151) concluded that the effect of n-3 LCP, including EPA and DHA, on CRP levels in human subjects was unconvincing.…”

Section: Effects Of Epa and Dha On Inflammationmentioning

confidence: 99%

The differential effects of EPA and DHA on cardiovascular risk factors

2011

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Compelling evidence exists for the cardioprotective benefits resulting from consumption of fatty acids from fish oils, EPA (20 :5n-3) and DHA (22 :6n-3). EPA and DHA alter membrane fluidity, interact with transcription factors such as PPAR and sterol regulatory element binding protein, and are substrates for enzymes including cyclooxygenase, lipoxygenase and cytochrome P450. As a result, fish oils may improve cardiovascular health by altering lipid metabolism, inducing haemodynamic changes, decreasing arrhythmias, modulating platelet function, improving endothelial function and inhibiting inflammatory pathways. The independent effects of EPA and DHA are poorly understood. While both EPA and DHA decrease TAG levels, only DHA appears to increase HDL and LDL particle size. Evidence to date suggests that DHA is more efficient in decreasing blood pressure, heart rate and platelet aggregation compared to EPA. Fish oil consumption appears to improve arterial compliance and endothelial function; it is not yet clear as to whether differences exist between EPA and DHA in their vascular effects. In contrast, the beneficial effect of fish oils on inflammation and insulin sensitivity observed in vitro and in animal studies has not been confirmed in human subjects. Further investigation to clarify the relative effects of consuming EPA and DHA at a range of doses would enable elaboration of current understanding regarding cardioprotective effects of consuming oily fish and algal sources of long chain n-3 PUFA, and provide clearer evidence for the clinical therapeutic potential of consuming either EPA or DHA-rich oils.

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“…32 ω3-PUFA-rich fish oil reduced CRP concentrations in patients with end-stage renal disease. 59 Our results indicate that ω3-PUFA treatment reduces the inflammatory response in DF patients, and this observation suggests that complementary treatment with ω3-PUFA could be used Fig. 2 Treatment with ω3-PUFA decreases serum IL-6 and Creactive protein (CRP) concentrations in patients with digestive fistulas (DF).…”

Section: Discussionmentioning

confidence: 92%

Effect of Oral ω3-Polyunsaturated Fatty Acids as a Complement Management to Control Fistula Output and Inflammation in Patients With Digestive Fistula

Martínez-Ordaz

Boscó-Gárate

Cérbulo-Vázquez

et al. 2017

Journal of Gastrointestinal Surgery

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Fish Oil Supplementation Lowers C‐Reactive Protein Levels Independent of Triglyceride Reduction in Patients With End‐Stage Renal Disease

Abstract: The study demonstrates that consuming 960 mg/d of EPA and 600 mg/d of DHA can lower CRP.

Cited by 61 publications

References 29 publications

Impact of a Nutritional Formula Enriched in Fish Oil and Micronutrients on Pressure Ulcers in Critical Care Patients

Impact of a Nutritional Formula Enriched in Fish Oil and Micronutrients on Pressure Ulcers in Critical Care Patients

The differential effects of EPA and DHA on cardiovascular risk factors

Effect of Oral ω3-Polyunsaturated Fatty Acids as a Complement Management to Control Fistula Output and Inflammation in Patients With Digestive Fistula

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