Fish oil supplementation attenuates neuroinflammation and alleviates depressive-like behavior in rats submitted to repeated lipopolysaccharide

Dang, Ruili; Zhou, Xueyuan; Tang, Mimi; Xu, Pengfei; Gong, Xun; Liu, Yuanyuan; Jiao, Hongxiao; Jiang, Pei

doi:10.1007/s00394-016-1373-z

Cited by 72 publications

(46 citation statements)

References 47 publications

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“…++ p < 0.01 compared to OVX group cytokines. Meanwhile, in accordance with the findings in the animal models of LPS or stress-induced depression [10], the anti-inflammatory and anti-depressant properties of PUFA were also verified in this OVX model. These beneficial effects are very likely to be associated with the phenotypic transition of microglia, as the present study showed that PUFA supplementation maintained the normal homeostatic balance between the M1 and the M2 phenotypes.…”

Section: Discussionsupporting

confidence: 88%

“…In support, it has been found that PUFA contains robust antidepressant effects in both clinical trials and chronic stress-induced depression-like rodents [23,24]. Additionally, we previously found that PUFA administration mitigates neuroinflammation and depression-like behaviors in animals exposed to repeated LPS challenge [10]. In fact, the antidepressant effect of PUFA is, at least partially, attributed to its immune-modulating actions and the inflammatory progression is tightly linked to the depression-line behaviors caused by either chronic stress, LPS or OVX.…”

Section: Discussionsupporting

confidence: 61%

“…The treatment procedures lasted for 10 weeks before sacrifice. The dosage of PUFA was selected based on our preliminary research and previous experiment showing the robust antidepressant effect of PUFA [10,11]. The animals in Sham group were sacrificed at the diestrus phase to avoid the effects of estrus cycle.…”

Section: Pufa Supplementation and Ovariectomymentioning

confidence: 99%

“…ω-3 polyunsaturated fatty acids (PUFA), the pleiotropic bioactive nutrient, contains anti-inflammatory and antidepressive activities [9]. Our previous researches demonstrated that PUFA can mitigate LPS-induced behavioral changes and restore overactivated neuroimmune function [10]. Although the neuroimmuneregulatory actions of PUFA has been found in various animal models, whether PUFA is effective in the immune activation induced by OVX remains unknown.…”

Section: Introductionmentioning

confidence: 99%

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Antidepressant activity of ω-3 polyunsaturated fatty acids in ovariectomized rats: role of neuroinflammation and microglial polarization

Song

Zhang

et al. 2020

Lipids Health Dis

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Background: Menopause predisposes individuals to affective disorders, such as depression, which is tightly related to neuroinflammation. While the neuroinflammatory condition has been demonstrated in ovariectomized (OVX) rodents, there is limited evidence concerning microglial polarization, a key process in brain immune activation, in menopause-related brain. Methods: Therefore, the present study aims to evaluate the polarized microglia in long-term OVX rats and we further explored whether supplementation of ω-3 polyunsaturated fatty acids (PUFA), the pleiotropic bioactive nutrient, is effective in the neurobehavioral changes caused by OVX. Results: Our data showed that OVX-induced anxiety and depression-like behaviors in rats, accompanied with increased neural apoptosis and microglial activation in the hippocampus. Additionally, OVX enhanced proinflammatory cytokines expression and suppressed the expression of anti-inflammatory cytokine, IL-10. Correspondingly, OVX reinforced NFκB signaling and shifted the microglia from immunoregulatory M2 phenotype to proinflammatory M1 phenotype. Meanwhile, daily supplementation with PUFA suppressed microglial M1 polarization and potentiated M2 polarization in OVX rats. In parallel, PUFA also exerted antidepressant and neuroprotective activities, accompanied with neuroimmune-modulating actions. Conclusion: Collectively, the present study firstly demonstrated the disturbed microglial polarization in the OVX brain and provide novel evidence showing the association between the antidepressant actions of PUFA and the restraint neuroinflammatory progression.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 61%

Section: Pufa Supplementation and Ovariectomymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Antidepressant activity of ω-3 polyunsaturated fatty acids in ovariectomized rats: role of neuroinflammation and microglial polarization

Song

Zhang

et al. 2020

Lipids Health Dis

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“…Additionally, nuclear erythroid-related factor 2 (Nrf2) was involved in metabolic homeostasis and inflammation and has become a promising target for the prevention or treatment of depressive disorders. As earlier researches showed that fish oil and conjugated linoleic acid can induce Nrf2 upregulation, their protective ability has been evaluated in a rat model of depression 28,29 . The discovery that the levels of linoleic acid, palmitic acid, stearic acid, oleamide, and palmitoleic www.nature.com/scientificreports www.nature.com/scientificreports/ acid were significantly altered in the CUMS group compared to the control rats may help to understand the molecular mechanisms associated with inflammation and oxidative stress that underlie depression.…”

Section: Discussionmentioning

confidence: 99%

Systematic impacts of chronic unpredictable mild stress on metabolomics in rats

Geng

Guo

Wang³

et al. 2020

Sci Rep

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Depression is the most common disabling psychiatric disease, with a high prevalence and mortality. Chronic unpredictable mild stress (CUMS) is a well-accepted method used to mimic clinical depression. Recent evidence has consistently suggested that the cumulative effects of CUMS could lead to allostatic overload in the body, thereby inducing systemic disorders; however, there are no previous systematic metabonomics studies on the main stress-targeted tissues associated with depression. A non-targeted gas chromatography-mass spectrometry (GC-MS) approach was used to identify metabolic biomarkers in the main stress-targeted tissues (serum, heart, liver, brain, and kidney) in a CUMS model of depression. Male Sprague-Dawley rats were randomly allocated to the CUMS group (n = 8) or a control group (n = 8). Multivariate analysis was performed to identify the metabolites that were differentially expressed between the two groups. There were 10, 10, 9, 4, and 7 differentially expressed metabolites in the serum, heart, liver, brain and kidney tissues, respectively, between the control and CUMS groups. These were linked to nine different pathways related to the metabolism of amino acids, lipids, and energy. In summary, we provided a comprehensive understanding of metabolic alterations in the main stress-targeted tissues, helping to understand the potential mechanisms underlying depression. An increasing body of evidence has revealed that the cumulative effect of stress can trigger allostatic overload 1-3. "Allostatic load" refers to the effects of prolonged continuous or intermittent activation of effectors involved in allostasis 4-6. Allostatic load has been associated with many diseases, such as cardiovascular disease, diabetes, stroke, chronic kidney disease, abdominal obesity, and depression 7,8. These all involve the whole body. Thus, the stress-induced allostatic overload involved in depression is focused on in our study. Depression is a seriously debilitating psychiatric disease, characterized by high mortality and morbidity. The chronic unpredictable mild stress (CUMS) model, a well-accepted animal model of depression, is used to explore the mechanisms underlying depression 9-11. One proposed mechanism involves allostatic load, a multidimensional biologic construct that involves biomarkers across the physiologic domains of neuroendocrine, autonomic, immune, and metabolic function 7. Allostatic overload resulting from CUMS in animal models causes atrophy of neurons in the hippocampus and prefrontal cortex 4,5 , myocardial ischemia 9 , abnormal hepatic metabolism 12 , and poor kidney outcomes 8,13. Thus, the impact of stress involves the whole body and depression is linked to multiple diseases such as cardiovascular disease 9. However, there are no previous systematic metabonomics studies focusing on the main stress-targeted tissues. Thus, the aim of the present study was to provide a panoramic and systematic view of metabolic alterations in stress-targeted tissues (serum, heart, liver, brain, and kidney) in the conte...

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Lipids

Castro-Torres

Hernández-Lozano

et al. 2021

Food Bioactives and Health

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Fish oil supplementation attenuates neuroinflammation and alleviates depressive-like behavior in rats submitted to repeated lipopolysaccharide

Abstract: These findings provide novel insights into the antidepressant action of PUFAs and further strengthen the link between inflammation and depression.

Cited by 72 publications

References 47 publications

Antidepressant activity of ω-3 polyunsaturated fatty acids in ovariectomized rats: role of neuroinflammation and microglial polarization

Antidepressant activity of ω-3 polyunsaturated fatty acids in ovariectomized rats: role of neuroinflammation and microglial polarization

Systematic impacts of chronic unpredictable mild stress on metabolomics in rats

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