Fish oil ingestion in smokers and nonsmokers enhances peroxidation of plasma lipoproteins

Harats, Dror; Dabach, Y.; Hollander, G.; Ben-Naim, M.; Schwartz, Ruth; Berry, Elliot M.; Stein, O.; Stein, Y.

doi:10.1016/0021-9150(91)90107-e

Cited by 123 publications

(62 citation statements)

References 37 publications

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“…This could be due to the presence of antioxidant constituents supplemented from N. sativa crude oil. The results of studies examining the effects of increased proportions of polyunsaturated fatty acids in the diet on indexes of lipid peroxidation in vivo are contradictory (Wander et al, 1996;Harats et al, 1991;Meydani et al, 1991). With fish-oil supplementation, there was no evidence of increased lipid peroxidation when assessed by plasma F2-isoprostanes and MDA (Higdon et al, 2000), which agreed with the present study.…”

Section: Discussionsupporting

confidence: 84%

Evaluation of the therapeutic effect of <em>Nigella sativa</em> crude oil and its blend with omega-3 fatty acid-rich oils in a modified hepatorenal syndrome model in rats

et al. 2015

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SUMMARY:In the present study, the hepato and reno-protective effect of Nigella sativa crude oil and its binary blend with omega-3 fatty acid-rich oils (fish and flaxseed oils) was studied in a modified hepatorenal syndrome model (MHRS) in rats. MHRS was induced through feeding a high fructose diet followed by an intraperitoneal injection of galactosamine hydrochloride. Nigella oil and its different blends were given as a daily oral dose to MHRS rats. Two control groups of MHRS and normal healthy rats were run. Different biochemical and nutritional parameters were assessed. The induction of MHRS produced liver and kidney dysfunction, and elevated oxidative stress, an inflammatory biomarker, endothelin 1, and plasma cholesterol. Reduced plasma high density lipoprotein cholesterol, albumin and Ca and elevated urinary N-acetyl-β-D-Glucosaminidase and liver fats were noticed. The administration of Nigella crude oil that originally had 0.2% total omega-3 fatty acids or its blend with fish oil (17.9% omega-3) or flaxseed oil (42.1% omega-3) significantly improved all biochemical parameters of MHRS. There was no significant difference in the biochemical parameters among the different oil treated groups regardless of the omega-3 fatty acid content. This may point out to the potential profound effect of the volatile oil fraction of Nigella crude oil which may compensates for its low omega-3 content. KEYWORDS: Hepatorenal syndrome; Nigella crude oil; Oil blends; Omega-3 fatty acidsRESUMEN: Evaluación del efecto terapéutico del aceite crudo de Nigella sativa y su mezcla con aceites ricos en ácidos grasos omega-3 en un modelo de síndrome hepatorenal modificado en ratas. En el presente estudio, el efecto hepato-y reno-protector de aceites crudos de Nigella sativa y su mezcla binaria con aceites ricos en ácidos grasos omega-3 (pescado y aceites de linaza) fue estudiado en un modelo modificado de síndrome hepatorenal (MHRS) en ratas. MHRS fue inducido a través de la alimentación de una dieta alta en fructosa seguido de la inyección intraperitoneal de clorhidrato de galactosamina. Diferentes aceites fueron suministrados como dosis oral diaria a ratas con MHRS. Se realizaron dos grupos de control de MHRS y ratas sanas normales. Se evaluaron diferentes parámetros bioquímicos y nutricionales. La inducción de la MHRS produce disfunción hepática y renal, elevado estrés oxidativo y biomarcadores inflamatorios, endotelina 1, y colesterol en plasma. Se observó una reducción del colesterol plasmatico de lipoproteínas de alta densidad, albúmina y Ca, elevación en orina de N-acetil-β-D-glucosaminidasa y de la grasa del hígado. La administración de aceite crudo de Nigella que tiene un 0,2% de ácidos grasos omega-3 totales o su mezcla con aceite de pescado (17,9% de omega-3) o aceite de linaza (42,1% de omega-3) mejoró significativamente todos los parámetros bioquímicos de MHRS. No hubo diferencia significativa en los parámetros bioquímicos entre los diferentes grupos tratados con los aceites ensayados independientemente del contenido de áci...

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Section: Discussionsupporting

confidence: 84%

Evaluation of the therapeutic effect of <em>Nigella sativa</em> crude oil and its blend with omega-3 fatty acid-rich oils in a modified hepatorenal syndrome model in rats

et al. 2015

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“…On the other hand, Meydani (Meydani et al, 1991) found increased TBARS in plasma samples from women given supplements of fish oil for 12 weeks. In agreement with these results, Harats et al (1991) observed both an increase in LDL TBARS and an accelerated metabolism of LDL by macrophages. These divergent/inconsistent findings may be because of different experimental settings, as these studies include relatively small sample sizes, different doses and compositions of n-3 PUFAs, short intervention periods, different amounts of antioxidants supplies and different methods used to quantify the oxidative burden and different methods to estimate TBARS.…”

Section: Introductionsupporting

confidence: 87%

“…The vast majority of studies investigating the oxidative potential of n-3 PUFAs include short-term supplementation periods (Harats et al, 1991;Nenseter et al, 1992;Bonanome et al, 1996;Wander et al, 1996;Hansen et al, 1998;Higdon et al, 2000). Long-term effects in vivo after 9 months of intervention were studied by Eritsland et al (1995), and susceptibility to lipid peroxidation induced in vitro was evaluated after 180 days of n-3 PUFAs treatment in the study by Palozza (Palozza et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

“…Despite several favourable effects of n-3 PUFAs on inflammation and atherothrombosis, concern has been raised, as n-3 PUFAs may have a potential to increase oxidative stress (Harats et al, 1991;Meydani et al, 1991), resulting in the formation of lipid peroxides. During peroxidation of PUFAs several chain reactions may modify lipids and lipoproteins containing PUFAs (Dargel, 1992;Halliwell & Chirico, 1993).…”

Section: Introductionmentioning

confidence: 99%

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Increased lipid peroxidation during long-term intervention with high doses of n-3 fatty acids (PUFAs) following an acute myocardial infarction

Grundt¹,

Nilsen²,

Mansoor³

et al. 2003

Eur J Clin Nutr

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“…In these studies, the minimum estimate of VE (mg of a-tocopherol equivalent) was calculated as follows: [0.3 x 5 x EPA (g) ] + [0.3 X 6 x DHA (g) ] . Tables 4 and 5 summarize the results of these studies [14,[37][38][39][40][41][42][43]. According to these studies except the one by Allard et al [43], an amount at least 2 times over the minimum estimate of VE calculated only from the EPA and DHA intakes should be secured to retain VE nutriture.…”

Section: Epamentioning

confidence: 99%

An Assessment of Appropriate Vitamin E Content in Fish Oil Capsules as Estimated by Lipid Peroxide and Vitamin E Levels in Human Blood.

Saito¹,

Iwamoto²,

Kaga

et al. 1999

J. Clin. Biochem. Nutr.

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Fish oil ingestion in smokers and nonsmokers enhances peroxidation of plasma lipoproteins

Cited by 123 publications

References 37 publications

Evaluation of the therapeutic effect of <em>Nigella sativa</em> crude oil and its blend with omega-3 fatty acid-rich oils in a modified hepatorenal syndrome model in rats

Evaluation of the therapeutic effect of <em>Nigella sativa</em> crude oil and its blend with omega-3 fatty acid-rich oils in a modified hepatorenal syndrome model in rats

Increased lipid peroxidation during long-term intervention with high doses of n-3 fatty acids (PUFAs) following an acute myocardial infarction

An Assessment of Appropriate Vitamin E Content in Fish Oil Capsules as Estimated by Lipid Peroxide and Vitamin E Levels in Human Blood.

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