1993
DOI: 10.1111/j.1749-6632.1993.tb35696.x
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Fish Oil in a High Lard Diet Prevents Obesity, Hyperlipemia, and Adipocyte Insulin Resistance in Rats

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Cited by 74 publications
(59 citation statements)
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“…There is evidence from studies in rodents of a relative protective effect of LC n-3 PUFA supplementation on weight gain in animals fed a high-fat diet, suggesting the potential for fish oil to promote greater weight-loss. 31 Additionally, in human studies, LC n-3 PUFA protected against loss of fat-free mass with 10% weight-loss in obese hypertensive men. 22 However, the present study does not support greater weightloss or differential changes in body composition with LC n-3 PUFA supplementation.…”
Section: Discussionmentioning
confidence: 99%
“…There is evidence from studies in rodents of a relative protective effect of LC n-3 PUFA supplementation on weight gain in animals fed a high-fat diet, suggesting the potential for fish oil to promote greater weight-loss. 31 Additionally, in human studies, LC n-3 PUFA protected against loss of fat-free mass with 10% weight-loss in obese hypertensive men. 22 However, the present study does not support greater weightloss or differential changes in body composition with LC n-3 PUFA supplementation.…”
Section: Discussionmentioning
confidence: 99%
“…Consequently, there has been considerable interest in the role of dietary fat in the development of adiposity. Compared to lard or corn oil-fed groups, total body fat or abdominal fat mass were considerably reduced in rodents fed with fish oil or perilla oil containing plenty of n-3 polyunsaturated fatty acids (PUFA) [4,5]. The polyunsaturated fatty acids, especially those in the class of n-3 fatty acids, are now known to affect all four of the metabolic nuclear receptors that modulate triglyceride (TG) levels.…”
Section: Introductionmentioning
confidence: 99%
“…Regular consumption of n-3 polyunsaturated fatty acids (n-3 PUFAs) may reduce adiposity in humans (Buckley and Howe 2010), in part, by inhibiting adipogenesis (Kopecký et al 2009) and stimulating fat oxidation (Couet et al 1997). Animal models have shown significant reductions in fat mass when dietary n-3 PUFAs, namely eicosapentaenoic (EPA) and docosahexaenoic acids (DHA), are substituted for saturated fats (Hainault et al 1993), monosaturated fats (Su and Jones 1993), and n-6 polyunsaturated fats (Jones 1989), after controlling for caloric intake. These findings have largely been confirmed by human studies (Thorsdottir et al 2007); however, information regarding whether the anti-obesity effects attributed to n-3 PUFA is dependent upon a specific genotype remains limited (Jourdan et al 2011).…”
Section: Introductionmentioning
confidence: 99%