Fish oil improves arterial compliance in non-insulin-dependent diabetes mellitus.

Abstract

In a double-blind, placebo-controlled study we investigated the effects of dietary fish oil supplementation on arterial wall characteristics in 20 patients with non-insulin-dependent diabetes mellitus. Estimates reflecting compliance values in the large arteries and more peripheral vasculature, as measured by pulse-contour analysis, improved significantly after 6 weeks of fish oil therapy compared with values recorded at baseline and after 6 weeks' administration of olive oil. The large-artery compliance estimate increased from 1.50 (confidence interval [CI], 1.31 to 1.69) mL/mm Hg at baseline to 1.68 (CI, 1.52 to 1.84) mL/mm Hg after fish oil administration (P < .01). The oscillatory compliance value increased from 0.015 (CI, 0.011 to 0.019) mL/mm Hg at baseline to 0.022 (CI, 0.016 to 0.028) mL/mm Hg after fish oil ingestion (P < .05). No changes occurred in arterial blood pressure, cardiac output, stroke volume, or systemic vascular resistance with either intervention. The improved compliance estimates with fish oil ingestion occurred without altering fasting blood glucose and cholesterol concentrations. These results support the hypothesis that fish oils alter vascular reactivity and favorably influence arterial wall characteristics in patients with non-insulin-dependent diabetes mellitus. These direct vascular effects, expressed at the level of the vessel wall, may contribute to the cardioprotective actions of fish oil in humans.

Fish oil supplementation improves large arterial elasticity in overweight hypertensive patients

“…The result was consistent with other studies (McVeigh et al, 1994;Nestel et al, 1997Nestel et al, , 2002O'Keefe et al, 2006). Large arterial stiffening was associated with hypertension, but both are not identified.…”

“…Clinical trials have showed that n-3 fatty acids (fish oil, flaxseed oil or purified eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) supplementation can improve arterial elasticity in normotensive subjects with dyslipidemia, obesity or diabetes (McVeigh et al, 1994;Nestel et al, 1997Nestel et al, , 2002.…”

Meta-analysis of the effects of n-3 polyunsaturated fatty acids on lipoproteins and other emerging lipid cardiovascular risk markers in patients with type 2 diabetes

“…The trials included in the pooled analyses were small, with a median of 23 patients. Seventeen of the published papers were duplicate publications of six trials [22, 27, 33, 34, 36-38, 40, 42-46, 48, 51, 54, 55]; multiple papers for each trial are indicated by the following grouping of references: [22,38], [27,34,36,37], [40,54,55], [42,48,51], [43,46], [44,45]. There was sufficient information on only 12 of the 98 outcomes to allow data to be pooled, the results of which are shown in Fig.…”

Carotid artery compliance in users of plant stanol ester margarine

“…Systemic arterial compliance was improved in dyslipidaemic subjects after 7-week supplementation with n-3 eicosapentaenoic acid and docosahexaenoic acid (Nestel et al, 2002). In addition, dietary fish oil supplementation for 6 weeks improved arterial compliance in patients with non-insulin dependent diabetes (McVeigh et al, 1994). Furthermore, n-3 rich flaxseed oil supplementation for 4 weeks increased systemic arterial compliance in obese subjects (Nestel et al, 1997).…”