Fish oil emulsions: what benefits can they bring?

Fürst, Peter; Kuhn, Katharina S.

doi:10.1054/clnu.1999.0072

Cited by 115 publications

(76 citation statements)

References 94 publications

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“…The second approach has been to partially replace soyabean oil with another oil that is believed to exert benefits in its own right. An example of this strategy is the use of fish oil (29)(30)(31)(32) . Fish oil contains the very long-chain n-3 PUFA EPA and DHA.…”

Section: Desirable Properties For Lipids To Be Used In Artificial Nutmentioning

confidence: 99%

Rationale and use of n-3 fatty acids in artificial nutrition

Calder

2010

Proc. Nutr. Soc.

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Lipids traditionally used in artificial nutrition are based on n-6 fatty acid-rich vegetable oils like soyabean oil. This may not be optimal because it may present an excessive supply of linoleic acid. One alternative to the use of soyabean oil is its partial replacement by fish oil, which contains n-3 fatty acids. These fatty acids influence inflammatory and immune responses and so may be useful in particular situations where those responses are not optimal. Fish oil-containing lipid emulsions have been used in parenteral nutrition in adult patients post-surgery (mainly gastrointestinal). This has been associated with alterations in patterns of inflammatory mediators and in immune function and, in some studies, a reduction in length of intensive care unit (ICU) and hospital stay. Perioperative administration of fish oil may be superior to post-operative. Parenteral fish oil has been used in critically ill adults. Here the influence on inflammatory processes, immune function and clinical endpoints is not clear, since there are too few studies and those that are available report contradictory findings. Fish oil is included in combination with other nutrients in various enteral formulas. In post-surgical patients and in those with mild sepsis or trauma, there is clinical benefit from a formula including fish oil and arginine. A formula including fish oil, borage oil and antioxidants has demonstrated marked benefits on gas exchange, ventilation requirement, new organ failures, ICU stay and mortality in patients with acute respiratory distress syndrome, acute lung injury or severe sepsis.

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Section: Desirable Properties For Lipids To Be Used In Artificial Nutmentioning

confidence: 99%

Rationale and use of n-3 fatty acids in artificial nutrition

Calder

2010

Proc. Nutr. Soc.

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“…Omega-3 fatty acid deficiency has been recognized and appreciated in recent times [16]. After intravenous administration, EPA and DHA promptly get incorporated into the cell membrane, compete with arachidonic acid (AA) in the cyclo-oxygenase and 5-lipoxygenase pathways, resulting in a reduced generation of diene prostanoids (e.g., PGE2, PGI2, and TXA2) and tetraene leukotrienes (e.g., LTB4), derived from AA in favor of the corresponding triene prostanoids (e.g., PGE3, PGI3, TXA3) and pentaene leukotriene (LTB5) derived from EPA [17].…”

Section: Discussionmentioning

confidence: 99%

Impact of Supplementing Preoperative Intravenous Omega 3 Fatty Acids in Fish Oil on Immunomodulation in Elderly Patients Undergoing Hip Surgery

et al. 2012

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“…AG n-3 participam diretamente da resposta do sistema imune ao se incorporarem em fosfolípides de membranas celulares e competirem como substrato alternativo a ácidos graxos ômega-6 (AG n-6), na síntese de mediadores inflamatórios da família dos eicosanóides, e como interruptores da inflamação, denominados resolvinas 3,4 . Particularmente, eicosanoides originados de EPA, como prostaglandina E3 (PGE3), leucotrieno B5 (LTB5) e tromboxano 3 (TBX3) têm potencial inflamatório significativamente menor que aqueles sintetizados a partir de ácido araquidônico (AA) proveniente de AG n-6, que incluem prostaglandina E2 (PGE2), leucotrieno B4 (LTB4) e tromboxano 2 (TBX2) 3,4 .…”

Section: áCidos Graxos ôMega-3unclassified

“…Adicionalmente, ácidos graxos ômega-3 são capazes de modificar a composição da membrana das células do sistema imunológico e afetar a estrutura de microdomínios de membrana funcionais relacionados ao início e propagação de eventos de sinalização celular, conhecidos como lipid rafts (4), (5), (6) . Vários receptores imunológicos são encontrados nos lipid rafts e a integridade desses domínios de membrana é fundamental para que a sinalização via receptores ocorra 5,6 .…”

Section: áCidos Graxos ôMega-3unclassified

“…Modular favoravelmente a resposta inflamatória sistêmica após estresse traumático pode contribuir para prevenir ou atenuar complicações clínico-cirúrgicas [1][2][3][4] . Nesse sentido, aplicação de terapia nutricional com nutrientes capazes de modular funções imunológicas e inflamatórias torna-se de grande interesse.…”

Section: Racional E Justificativa Do Estudo Racional E Justificativa unclassified

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Repercussão do uso parenteral prévio de emulsão lipídica de óleo de peixe sob a resposta inflamatória sistêmica e sobrevida em modelo experimental de pancreatite aguda

Garla¹

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Fish oil emulsions: what benefits can they bring?

Cited by 115 publications

References 94 publications

Rationale and use of n-3 fatty acids in artificial nutrition

Rationale and use of n-3 fatty acids in artificial nutrition

Impact of Supplementing Preoperative Intravenous Omega 3 Fatty Acids in Fish Oil on Immunomodulation in Elderly Patients Undergoing Hip Surgery

Repercussão do uso parenteral prévio de emulsão lipídica de óleo de peixe sob a resposta inflamatória sistêmica e sobrevida em modelo experimental de pancreatite aguda

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