Fish oil diet effects on alveolar bone loss, in hypercholesterolemic rats

Antona, M.; Ramos, Cecilia; Stranges, Andrea; Monteiro, Andrea Gloria Ferreira; Chaves, María Macarena Gonzales; Mandalunis, Patricia; Zago, Valeria; Friedman, Sílvia; Macri, Elisa Vanesa

doi:10.1016/j.archoralbio.2019.104553

Cited by 7 publications

(6 citation statements)

References 52 publications

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“…31 Furthermore, fish oil diet was shown to decrease ABL in hypercholesterolemic rats with ligature-induced periodontitis. 41 B. lactis administration significantly decreased CAL and ABL in an experimental periodontitis study. 19 Garcia et al 21 presented that local application of Saccharomyces cerevisiae in combination with SRP significantly decreased ABL in the furcation area of the mandibular first molars of rats.…”

Section: Discussionmentioning

confidence: 87%

Comparison of the Effects of Omega 3 and Probiotics on Alveolar Bone Loss in Rats: An Immunohistochemical Study

Doğan¹,

Doğan²,

Özmen³

2021

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

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Omega 3 and probiotics have been demonstrated to have beneficial effects in periodontal disease pathogenesis. Inducible nitric oxide synthase is an important mediator regulating immune response. The objective of this study was to compare the impacts of omega 3 and probiotic supplementation on alveolar bone loss and gingival inducible nitric oxide synthase levels in an experimental periodontitis model. Material and Methods: Thirty-two rats were separated into 4 equal groups as control, periodontitis, omega 3, and probiotic. Omega 3 or probiotic was supplemented by oral gavage and experimental periodontitis was induced to the rats in periodontitis, omega 3, and probiotic groups by ligature. Alveolar bone loss was measured histometrically. The number of neutrophils 2 was counted and gingival inducible nitric oxide synthase levels were analysed immunohistochemically.Results: Alveolar bone loss significantly increased in periodontitis induced groups, compared to control group and decreased in omega 3 and probiotic groups, compared to the periodontitis group (p <0.05). Probiotic group had further decrease in alveolar bone loss than the omega 3 group (p <0.05). The number of neutrophils and gingival inducible nitric oxide synthase levels were higher in the periodontitis, omega 3, and probiotic groups than those in the control group, and decreased in omega 3 and probiotic groups, compared to the periodontitis group (p <0.05). Conclusion:We suggest that omega 3 and probiotic administrations could reduce alveolar bone loss by decreasing gingival inducible nitric oxide synthase. Probiotic support seems to have more beneficial reducing alveolar bone loss, compared to omega 3.

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Section: Discussionmentioning

confidence: 87%

Comparison of the Effects of Omega 3 and Probiotics on Alveolar Bone Loss in Rats: An Immunohistochemical Study

Doğan¹,

Doğan²,

Özmen³

2021

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

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“…The histomorphometric measurements revealed that hPL in the inter‐radicular alveolar bone was found to be significantly higher in thymol‐DDSA‐CHI when compared to thymol‐CHI. These findings would suggest that only unmodified thymol‐CHI exert their beneficial effects on periodontal tissue (Table 1), since the hPL that joints the tooth root, is a feature of bone loss attachment 30 . Additionally, CHI and DDSA‐CHI showed no significant differences when compared to thymol‐DDSA‐CHI.…”

Section: Resultsmentioning

confidence: 94%

“…The use of biopolymers as delivery systems has been consolidated over the years 30–33 and their modification can be translated, for instance, into the synthesis of materials that respond to stimuli or with a sustained release of bioactives.…”

Section: Discussionmentioning

confidence: 99%

Dodecenylsuccinic anhydride modified chitosan hydrogels for the sustained delivery of hydrophobic drugs. The case of thymol buccal delivery

Echazú

Antona

Perna

et al. 2021

J of Applied Polymer Sci

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Chitosan polymer as a bioactive carrier has an emerging importance due to its great versatility. Many strategies are reported for enhancing its properties. Herein, chitosan hydrogels modified by dodecenylsuccinic anhydride (DDSA) are prepared, characterized by SEM, FTIR, 13C NMR while their mechanical properties and cytotoxicity are assessed. Chitosan modification was studied by FTIR and 13C NMR. According to rheological measurements, modified chitosan hydrogels present a predominantly elastic behavior and exert a higher compressive strength than chitosan hydrogels. Furthermore, this work evaluates thymol incorporation, its release profile as well as its in vivo performance in a periodontitis rat model. In vitro studies reveal that thymol‐loaded‐DDSA‐chitosan hydrogels possess antimicrobial activity against Staphylococcus aureus and Pseudomonas aeruginosa for 2 days and antioxidant activity for 5 days. The incorporation of hydrophobic chains improves thymol release profile; however, DDSA‐chitosan hydrogels cytotoxicity is greater when compared to chitosan hydrogels. Finally, in a preliminary in vivo study, the local application of thymol‐loaded hydrogels is evaluated during a one‐week period. The histomorphometric measurements indicate that periodontal damage is lower when thymol is administrated in chitosan hydrogels in comparison to DDSA‐chitosan hydrogels. Nevertheless, DDSA‐chitosan hydrogels could still be useful for the sustained local delivery of hydrophobic drugs.

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“…A 2020 study investigated whether fish oil has the potential for periodontitis treatment in a hypercholesterolemic rat model with ligature-induced periodontitis (Antona et al, 2020). Fish oil prevents bone loss and promotes bone trabeculae, the substitution of saturated fat, periodontal bone support (PBS), and a percentage of lower bone volume (LBV) and total lower volume (TLV).…”

Section: Trend Analysis Of Marine Bioactive Substances (Mbs) Against ...mentioning

confidence: 99%

Therapeutic effect of marine bioactive substances against periodontitis based on in vitro, in vivo, and clinical studies

Lee¹,

Kwon²,

Jung³

2023

Fish Aquat Sci

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Marine bioactive substances (MBS), such as phlorotannins, collagens, peptides, sterols, and polysaccharides, are increasing attention as therapeutic agents for several diseases due to their pharmacological effects. Previous studies have demonstrated the biological activities of MBS including antibacterial, anticoagulant, antidiabetic, antimicrobial, anti-inflammatory activities. Among numerous human diseases, periodontitis is one of the high-prevalence inflammatory diseases in the world. To treat periodontitis, several surgeries (bone grafting, flap surgery, and soft tissue graft) are usually used. However, the surgery for patients with chronic periodontitis induces several side effects, including additional inflammatory responses at the operated site, chronic wound healing, and secondary surgery. Therefore, this review assessed the most recent trends in MBS using Google Scholar, PubMed, and Web of Science search engines to develop marine-derived therapeutic agents for periodontitis. Further, we summarized the current applications and therapeutic potential of MBS to serve as a reference for developing novel technologies applied to MBS against periodontitis treatment.

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Fish oil diet effects on alveolar bone loss, in hypercholesterolemic rats

Cited by 7 publications

References 52 publications

Comparison of the Effects of Omega 3 and Probiotics on Alveolar Bone Loss in Rats: An Immunohistochemical Study

Comparison of the Effects of Omega 3 and Probiotics on Alveolar Bone Loss in Rats: An Immunohistochemical Study

Dodecenylsuccinic anhydride modified chitosan hydrogels for the sustained delivery of hydrophobic drugs. The case of thymol buccal delivery

Therapeutic effect of marine bioactive substances against periodontitis based on in vitro, in vivo, and clinical studies

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