Fish oil and wheat germ oil supplementation modulates brain injury in streptozotocin‐induced diabetic rats

Khedr, Naglaa F.

doi:10.1111/1753-0407.12518

Cited by 8 publications

(9 citation statements)

References 40 publications

(96 reference statements)

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“…Our results demonstrated the neuroprotective effect of WGO against deltamethrin induced cerebellar cortical damage. This finding is supported by previous reports which stated that WGO possesses a neuroprotective effects through its anti-inflammatory and antioxidant actions [37] . WGO significantly attenuates the severity of lipid peroxidation and enhances the antioxidant enzyme activity.…”

Section: Discussionsupporting

confidence: 91%

Wheat germ oil attenuates deltamethrin-induced injury in rat cerebellar cortex: Histological and immunohistochemical study

Kassab

2018

Egyptian Journal of Histology

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Introduction: Deltamethrin, a widely used insecticide, has neurotoxic effects causing apoptosis. Wheat germ oil is a highly valuable part of wheat that proved to have neuro-protective and anti-apoptotic effects. Aim of the work: To evaluate the possible protective role of wheat germ oil in deltamethrin-induced injury in rat cerebellar cortex. Materials and Methods: Four equal groups of adult male albino rats "10 rats, each" were used; control group, wheat germ oil (WGO) group (100 mg/kg), deltamethrin group (0.6 mg/kg), and deltamethrin & wheat germ oil combination group. Daily oral doses were given for consecutive thirty days. Specimens of the cerebellum were processed for histological and immunohistochemical study. Morphometric studies and statistical analysis were performed. Results: In comparison with the control group, the specimens of the deltamethrin group showed disturbed monolayer arrangement of Purkinje cells with loss of the normal shape. Shrunken deeply stained Purkinje cells as well as some lost cells were noticed. Immunohistochemically, a significant decrease in Bcl2 immunoreaction revealed together with a significant increase in Bax immunoreactivity in Purkinje cells. Moreover, significant increase in the GFAP immune-expression was seen in all cortical layers. In contrast, minimal changes appeared in the group treated concomitantly with deltamethrin and wheat germ oil. Conclusion: Wheat germ oil attenuates deltamethrin-induced structural changes in rat cerebellar cortex.

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Section: Discussionsupporting

confidence: 91%

Wheat germ oil attenuates deltamethrin-induced injury in rat cerebellar cortex: Histological and immunohistochemical study

Kassab

2018

Egyptian Journal of Histology

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“…Wheat germ is typically discarded during the milling process but has been used to produce wheat germ oil. In the previous decade, numerous in vitro and in vivo studies have investigated the various health aspects of wheat germ, especially wheat germ oil (Arshad et al, 2013 ; Khedr, 2017 ) that can improve lipid metabolism (Khalil et al, 2010 ) and lower oxidative stress (Alessandri et al, 2006 ). Fermented wheat germ extract (FWGE) has been shown to have antimetastatic effects in cells and animals (Fajka-Boja et al, 2002 ; Heimbach et al, 2007 ; Hidvegi et al, 1998 ) including in colorectal (Farkas, 2005 ) and ovarian cancer (Koh et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of wheat germ on metabolic markers: a systematic review and meta-analysis of randomized controlled trials

Liaqat

Jeong

Kim

et al. 2020

Food Sci Biotechnol

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This systematic review and meta-analysis aim to evaluate the association of wheat germ interventions and metabolic markers. An electronic search was performed by mid-May 2019 in the PubMed, Google Scholar, and Web of Science databases. Quality was evaluated using the risk of bias assessment tools. Thirty-three randomized controlled trials (RCTs) were identified, among which ten were suitable and systematically reviewed based on biomarkers (cholesterol, triglycerides, glucose, and oxidative stress). Three biomarkers in five eligible studies were investigated by meta-analysis. Total cholesterol showed non-significant results (p = 0.98), with standard mean difference (SMD) of-0.01 (95% confidence interval;-0.17, 0.16). The SMD was-0.06 (95% CI-0.41, 0.29, n = 4) for triglycerides and-0.09 (95% CI-0.62, 0.45, n = 2) for glucose. No biomarkers showed heterogeneity (0%). This review revealed non-significant association between wheat germ interventions and metabolic markers. Sensitive analysis with high-quality RCTs may be worth trying.

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“…44 The neuronal injury may be exacerbated by diabetes, with a notable reduction being observed in GSH. 45 Furthermore, Trx2 has been suggested to be related to neuronal injury and has neuronal protective effects on the human brain when responding to neurodegeneration, suggesting that Trx possesses a neuronal protective effect. 46 Trx has also been shown to be capable of exerting antioxidative, antiinflammatory, and antiapoptotic effects.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‐25 aggravates Aβ1‐42‐induced hippocampal neuron injury in Alzheimer's disease by downregulating KLF2 via the Nrf2 signaling pathway in a mouse model

Duan

2019

J of Cellular Biochemistry

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Recently, numerous microRNAs (miRNAs) have been considered as key players in the regulation of neuronal processes. The purpose of the present study is to explore the effect of miR‐25 on hippocampal neuron injury in Alzheimer's disease (AD) induced by amyloid β (Aβ) peptide fragment 1 to 42 (Aβ1‐42) via Kruppel‐like factor 2 (KLF2) through the nuclear factor‐E2‐related factor 2 (Nrf2) signaling pathway. A mouse model of AD was established through Aβ1‐42 induction. The underlying regulatory mechanisms of miR‐25 were analyzed through treatment of miR‐25 mimics, miR‐25 inhibitors, or small interfering RNA (siRNA) against KLF2 in hippocampal tissues and cells isolated from AD mice. The targeting relationship between miR‐25 and KLF2 was predicted using a target prediction program and verified by luciferase activity determination. MTT assay was used to evaluate the proliferative ability and flow cytometry to detect cell cycle distribution and apoptosis. KLF2 was confirmed as a target gene of miR‐25. When the mice were induced by Aβ1‐42, proliferation was suppressed while apoptosis was promoted in hippocampal neurons as evidenced by lower levels of KLF2, Nrf2, haem oxygenase, glutathione S transferase α1, glutathione, thioredoxin, and B‐cell lymphoma‐2 along with higher bax level. However, such alternations could be reversed by treatment of miR‐25 inhibitors. These findings indicate that miR‐25 may inhibit hippocampal neuron proliferation while promoting apoptosis, thereby aggravating hippocampal neuron injury through downregulation of KLF2 via the Nrf2 signaling pathway.

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Fish oil and wheat germ oil supplementation modulates brain injury in streptozotocin‐induced diabetic rats

Abstract: Supplementation of the diet with the FO + WGO mix modulated diabetic brain injury and this mix could potentially be used for preventing diabetic neurodegenerative sequelae.

Cited by 8 publications

References 40 publications

Wheat germ oil attenuates deltamethrin-induced injury in rat cerebellar cortex: Histological and immunohistochemical study

Wheat germ oil attenuates deltamethrin-induced injury in rat cerebellar cortex: Histological and immunohistochemical study

Effect of wheat germ on metabolic markers: a systematic review and meta-analysis of randomized controlled trials

MicroRNA‐25 aggravates Aβ1‐42‐induced hippocampal neuron injury in Alzheimer's disease by downregulating KLF2 via the Nrf2 signaling pathway in a mouse model

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