Fish Oil and Postoperative Atrial Fibrillation: The Omega-3 Fatty Acids for Prevention of Post-operative Atrial Fibrillation (OPERA) randomized trial

Ryan, Jordan

doi:10.1016/j.jemermed.2013.01.005

Cited by 2 publications

(2 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This might also lead to an augmented synthesis of antithrombotic EPA metabolites, which may contribute to diminished platelet aggregation [55,56]. This issue was investigated by a secondary analysis of the OPERA Trial, which was a multinational, placebo-controlled randomized trial evaluating the impact of fish oil on the incidence of atrial fibrillation post cardiac surgery [57]. This analysis revealed no increase in perioperative bleeding incidence following fish oil supplementation; instead, a significant decrease in the number of blood transfusion was observed.…”

Section: Discussionmentioning

confidence: 99%

Effects of Omega-3 Fatty Acids on Postoperative Inflammatory Response: A Systematic Review and Meta-Analysis

Mohsen,

Stroemer,

Mayr

et al. 2023

Nutrients

View full text Add to dashboard Cite

Initial evidence indicates that preoperatively initiated administration of omega-3 fatty acids (FAs) attenuates the postoperative inflammatory reaction. The effects of immunonutrition containing omega-3 FAs, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on the inflammatory response to abdominal surgery continues to be unclear, although improved outcomes have been reported. Therefore, we determined the effectiveness of preoperatively initiated omega-3 FAs administration on postoperative inflammation defined as CRP (C-Reactive Protein), IL-6 (Interleukin 6), and WBC (White Blood Count) and potential effects on postoperative length of hospital stay (LOS) due to an improved inflammatory response. Methods: a literature search of Cochrane Library was conducted to identify all randomized controlled trials (RCTs) investigating the effects of preoperatively initiated omega-3 to standard care, placebo, or other immunonutrients excluding omega-3 FAs in patients undergoing abdominal surgery until the end of December 2022. Results: a total of 296 articles were found during the initial search. Thirteen RCTs involving 950 patients were identified that met the search criteria. These were successively analyzed and included in this meta-analysis. There was no significant difference between the groups with respect to inflammatory markers IL-6: −0.55 [−1.22; 0.12] p = 0.10, CRP: −0.14 [−0.67; 0.40] p = 0.55, WBC: −0.58 [−3.05; 1.89] p = 0.42, or hospital stay −0.5 [−1.43; 0.41] p = 0.2. Conclusion: although reduced inflammatory markers were observed, preoperative administration of omega-3 FAs immunonutrients had no significant effect on the postoperative inflammatory response in patients undergoing abdominal surgeries. Yet, results obtained from this study are inconclusive, likely attributed to the limited number of trials and patients included. Further studies are required to obtain a better educated verdict.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of Omega-3 Fatty Acids on Postoperative Inflammatory Response: A Systematic Review and Meta-Analysis

Mohsen,

Stroemer,

Mayr

et al. 2023

Nutrients

View full text Add to dashboard Cite

show abstract

“…Eighteen trials were conducted in Europe, (134-140, 142, 144-147, 150, 154, 155, 158-160) five in the US, (131,133,153,156,157) three in Japan, (151,161,162) two in Australia (141) and New Zealand, (152) and four were multinational trials. (132,143,148,149) Two trials had an intervention duration shorter than 1 year, (148,161) and the intervention duration of the other trials were between 1 to 7.4 years (median 2 years, interquartile range 0.45-3.55). One trial was conducted in men, (136) and the others in either sex, with the proportion of females being between 6.5% and 67%.…”

Section: Supplementary Text 1 Detailed Information About Data Extract...mentioning

confidence: 99%

Dietary intake, biomarkers and supplementation of fatty acids and risk of coronary events: a systematic review and dose-response meta-analysis of randomized controlled trials and prospective observational studies

Jayedi,

Soltani,

Emadi

et al. 2023

Critical Reviews in Food Science and Nutrition

View full text Add to dashboard Cite

Fish Oil and Postoperative Atrial Fibrillation: The Omega-3 Fatty Acids for Prevention of Post-operative Atrial Fibrillation (OPERA) randomized trial

Cited by 2 publications

References 37 publications

Effects of Omega-3 Fatty Acids on Postoperative Inflammatory Response: A Systematic Review and Meta-Analysis

Effects of Omega-3 Fatty Acids on Postoperative Inflammatory Response: A Systematic Review and Meta-Analysis

Dietary intake, biomarkers and supplementation of fatty acids and risk of coronary events: a systematic review and dose-response meta-analysis of randomized controlled trials and prospective observational studies

Contact Info

Product

Resources

About