Fish Oil and Adjuvant-Induced Arthritis: Inhibitory Effect on Leukocyte Recruitment

Estevão-Silva, Camila Fernanda; Ames, Franciele Queiroz; Silva-Comar, Francielli Maria de Souza; Kummer, Raquel; Tronco, Rafael Prizon; Cuman, Roberto Kenji Nakamura; Bersani-Amado, Ciomar Aparecida

doi:10.1007/s10753-015-0252-8

Cited by 12 publications

(11 citation statements)

References 40 publications

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“…Blood was collected by means of tail incision to obtain the total and differential count of circulating leukocytes. Total and differential counts of leukocytes recruited into the femorotibial joint cavity were additionally performed at the 19th day as previously described [ 25 ].…”

Section: Methodsmentioning

confidence: 99%

Anti‐Inflammatory and Antioxidant Actions of Methyl Jasmonate Are Associated with Metabolic Modifications in the Liver of Arthritic Rats

Sá‐Nakanishi

Soni-Neto

Moreira

et al. 2018

Oxidative Medicine and Cellular Longevity

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Methyl jasmonate (MeJA) is a fatty acid-derived cyclopentanone which shares structural similarities with prostaglandins and has been under study as a promising anti-inflammatory agent. This study investigated the actions of MeJA on systemic inflammation and oxidative status in rats with adjuvant-induced arthritis, a model for rheumatoid arthritis. MeJA (75 to 300 mg·kg−1) was administrated orally during 18 days after arthritis induction with Freund's adjuvant. Articular and systemic inflammation was greatly increased in arthritic rats, likewise the oxidative stress in plasma and liver. The hepatic glucokinase activity and glycolysis were increased in arthritic rats. MeJA decreased most inflammatory parameters and abolished the increased protein carbonylation in plasma and liver, diminished the increased hepatic ROS content, and restored the hepatic GSH/GSSG ratio in arthritic rats. However, the MeJA treatment decreased the hepatic glucokinase activity and glycolysis and stimulated mitochondrial ROS production in healthy and arthritic rats. Oxygen uptake was increased by MeJA only in livers from treated arthritic rats. This action may bear relation to the increased activity of mitochondrial NADP+-dependent enzymes to provide reducing equivalents for the glutathione cycle. These beneficial effects, however, are associated with a decreased glucose flux through the glycolysis in the liver of arthritic and healthy rats.

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Section: Methodsmentioning

confidence: 99%

Anti‐Inflammatory and Antioxidant Actions of Methyl Jasmonate Are Associated with Metabolic Modifications in the Liver of Arthritic Rats

Sá‐Nakanishi

Soni-Neto

Moreira

et al. 2018

Oxidative Medicine and Cellular Longevity

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“…The procedures were repeated three times to evaluate all parameters of this study. 28 2.5 | Blood collection and tissue preparation Rats fasted for 12 hours were deeply anesthetized with sodium thiopental (100 mg·kg −1 ) plus lidocaine (10 mg·kg −1 ) and the peritoneal cavity was exposed. A, Chemical structure of β-caryophyllene (red circles show the sites for antioxidant action).…”

Section: Experimental Designmentioning

confidence: 99%

“…Total and differential counts of leukocytes recruited into the femorotibial joint cavity were additionally performed at day 19 as previously described. 28…”

Section: Experimental Designmentioning

confidence: 99%

β‐Caryophyllene, the major constituent of copaiba oil, reduces systemic inflammation and oxidative stress in arthritic rats

Ames-Sibin

Barizão

Castro-Ghizoni

et al. 2018

J of Cellular Biochemistry

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The current study investigated the action of β-caryophyllene, the major constituent of copaiba oil, on the systemic inflammation, oxidative status, and liver cell metabolism of rats with adjuvant-induced arthritis, a model for rheumatoid arthritis. This study also compared the actions of β-caryophyllene with those previously reported for copaiba oil on arthritic rats. For this purpose, Holtzman healthy and arthritic rats received 215 and 430 mg·kg β-caryophyllene orally once a day during 18 days. Both doses of β-caryophyllene reduced the adjuvant-induced paw edema, swollen of lymph nodes, and number of circulating and articular leukocytes. β-Caryophyllene, at the dose of 430 mg·kg , abolished the increases of protein carbonyl groups and myeloperoxidase activity in the liver and plasma of arthritic rats and, at both doses, it restored the increased levels of reactive oxygen species and reduced glutathione in the arthritic liver. These beneficial actions were of the same extension as those of copaiba oil ( Copaifera reticulata) and, therefore, β-caryophyllene is possibly responsible for the anti-inflammatory and antioxidant actions of the oil. Hepatic gluconeogenesis was 40% lower in arthritic rats, which also presented a reduced number of hepatocytes per liver area (-23%) associated with increased hepatocyte area (+18%) and liver weight (+50%). None of these hepatic alterations were improved by β-caryophyllene, but not even by ibuprofen. However, unlike copaiba oil, β-caryophyllene did not modify the hepatic morphology and metabolism of healthy rats. These results reveal that β-caryophyllene improves the systemic inflammation and oxidative status of arthritic rats and, in addition, it was not associated with hepatotoxicity.

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“…MAG-DPA and MAG-EPA can reduce hind paw thickness, prevent disease progression and reduce cytokines (IL-17A, IL-1β, IL-6, TNF-α) and metalloproteinase (MMP-2 and MMP-9) production, while MAG-DHA, after an initial efficacy, does not shown any benefit in later stages of the disease [ 55 ]. In the same murine model, the administration of fish oil preparation (FOP) (75, 150, and 300 mg/kg for 21 days after the induction of the arthritis) is able to decrease the migration, adhesion, and recruitment in the joints of leukocytes [ 56 ]. Furthermore, the administration of DHA (both orally and intra-articularly) reduces the nociception and joint swelling in mice after the injection of Complete Freund’s Adjuvant (CFA) in the right knee [ 57 ].…”

Section: Pufas and Animal Models Of Ramentioning

confidence: 99%

Polyunsaturated fatty acids: any role in rheumatoid arthritis?

et al. 2017

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BackgroundPolyunsaturated fatty acids (PUFAs) are members of the family of fatty acids and are included in the diet. Particularly, western diet is usually low in n-3 PUFAs and high in n-6 PUFAs. PUFAs play a central role in the homeostasis of immune system: n-6 PUFAs have predominantly pro-inflammatory features, while n-3 PUFAs seem to exert anti-inflammatory and pro-resolving properties. Rheumatoid arthritis (RA) is a chronic inflammatory arthritis in which many inflammatory pathways contribute to joint and systemic inflammation, disease activity, and structural damage. Research on PUFAs could represent an important opportunity to better understand the pathogenesis and to improve the management of RA patients.MethodsWe searched PubMed, Embase, EBSCO-Medline, Cochrane Central Register of Controlled Trials (CENTRAL), CNKI and Wanfang to identify primary research reporting the role of n-3 PUFAs in rheumatoid arthritis both in humans and in animal models up to the end of March 2017.ResultsData from animal models allows to hypothesize that n-3 PUFAs supplementation may represent an interesting perspective in future research as much in prevention as in treating RA. In humans, several case-control and prospective cohort studies suggest that a high content of n-3 PUFAs in the diet could have a protective role for incident RA in subjects at risk. Moreover, n-3 PUFAs supplementation has been assessed as a valuable therapeutic option also for patients with RA, particularly in order to improve the pain symptoms, the tender joint count, the duration of morning stiffness and the frequency of NSAIDs assumption.Conclusionsn-3 PUFAs supplementation could represent a promising therapeutic option to better control many features of RA. The impact of n-3 PUFAs on radiographic progression and synovial histopathology has not been yet evaluated, as well as their role in early arthritis and the combination with biologics.

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Fish Oil and Adjuvant-Induced Arthritis: Inhibitory Effect on Leukocyte Recruitment

Cited by 12 publications

References 40 publications

Anti‐Inflammatory and Antioxidant Actions of Methyl Jasmonate Are Associated with Metabolic Modifications in the Liver of Arthritic Rats

Anti‐Inflammatory and Antioxidant Actions of Methyl Jasmonate Are Associated with Metabolic Modifications in the Liver of Arthritic Rats

β‐Caryophyllene, the major constituent of copaiba oil, reduces systemic inflammation and oxidative stress in arthritic rats

Polyunsaturated fatty acids: any role in rheumatoid arthritis?

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