Fish oil ameliorates sickness behavior induced by lipopolysaccharide in aged mice through the modulation of kynurenine pathway

Gomes, Marcelo Gomes de; Souza, Leandro Cattelan; Góes, André Rossito; Fabbro, Lucian Del; Filho, Carlos Borges; Donato, Franciele; Prigol, Marina; Luchese, Cristiane; Roman, Silvane Souza; Puntel, Robson Luiz; Boeira, Silvana Peterini; Jessé, Cristiano Ricardo

doi:10.1016/j.jnutbio.2018.05.002

Cited by 22 publications

(18 citation statements)

References 55 publications

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“…In particular, it has been reported that low n-3 PUFA intake in diets is correlated with the development of depressive and anxiety-like symptoms [32]. The fish oil treatment significantly attenuated the decrease of serotonin levels in brain areas induced by lipopolysaccharide [33]. Therefore, whether the higher n-3 PUFA content contributes to PPD in clinical improvement warrants further research.…”

Section: Discussionmentioning

confidence: 99%

Association between Postpartum Nutritional Status and Postpartum Depression Symptoms

Lin

Chen

et al. 2019

Nutrients

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Taiwanese women may practice traditional confinement after childbirth, and no study has investigated the nutritional status and the effects of postpartum depression on such women. The aim of this study was to investigate the association between nutritional status and postpartum depression at 6–8 weeks postpartum. A cross-sectional study was conducted on postpartum women who returned to the obstetrics and gynecology clinic for routine examination from January 2016 to September 2017. A total of 344 women received assessments based on the Edinburgh Postnatal Depression Scale (EPDS). An EPDS score of ≥10 indicated the presence of postpartum depressive symptoms (PPDS). A total of 97 women without such symptoms and 23 with PPDS completed nutritional parameter analyses and questionnaires. The results showed that the prevalence of postpartum depression (PPD) was 8.4%. The proportion was 70% for those who practiced confinement at home, significantly higher than for those in the non-PPDS group (45%). The overall psychological stress score was significantly higher and the postpartum care satisfaction score was significantly lower in those with PPDS compared to those without. In terms of nutritional biomarkers, the plasma riboflavin levels in the PPDS group were significantly lower than those in their symptomless counterparts (13.9%). The vitamin D insufficiency and deficiency rates in the non-PPD and PPDS groups were 35%, 41%, 48%, 26%, respectively. However, compared with those in the non-PPDS group, those with PPDS had significantly higher ratios of Σn-6/Σn-3, C20:3n-6/C18:3n-6, and C20:4n-6/(C20:5n-3 + C22:6n-3) (by 8.2%, 79.7%, and 8.8%, respectively), whereas they had lower ratios of C22:6n-3/C22:5n-6 (by 15.5%). Higher plasma riboflavin and erythrocyte C16:1n-9, C24:1n-9, C18:3n-6, and C20:5n-3 levels and lower Σn-6 fatty acid and C22:5n-6 levels decreased the risk of PPD after type of confinement, overall mental stress scores, and postpartum care satisfaction scores were adjusted for the logistic regression analysis. In conclusion, the plasma riboflavin level and erythrocyte fatty acid composition are potentially major contributors to PPD development.

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Section: Discussionmentioning

confidence: 99%

Association between Postpartum Nutritional Status and Postpartum Depression Symptoms

Lin

Chen

et al. 2019

Nutrients

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“…The kynurenine pathway of tryptophan degradation is increased in response to inflammation (47), and activation of this pathway is associated with depression (48). A previous study demonstrated that fish oil supplementation attenuated the activation of the kynurenine pathway upon administration of lipopolysaccharide as a model of sickness behavior (49). Another recent paper describes how n3-PUFAs protect against hippocampal neurogenesis in response to IL-1β by modulating the kynurenine pathway (50).…”

Section: Young Vs Oldmentioning

confidence: 99%

Distinct Influence of Omega-3 Fatty Acids on the Plasma Metabolome of Healthy Older Adults

Xyda

Vučković

Petterson

et al. 2019

The Journals of Gerontology: Series A

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Omega-3 polyunsaturated fatty acids (n3-PUFA) are well recognized for their potent triglyceride-lowering effects, but the potential influence of these bioactive lipids on other biological processes, particularly in the context of healthy aging, remains unknown. With the goal of gaining new insight into some less well-characterized biological effects of n3-PUFAs in healthy older adults, we performed metabolomics of fasting peripheral blood plasma collected from 12 young adults and 12 older adults before and after an open-label intervention of n3-PUFA (3.9 g/day, 2.7 g eicosapentaenoic [EPA], 1.2 g docosahexaenoic [DHA]). Proton nuclear magnetic resonance (1H-NMR) based lipoprotein subclass analysis revealed the expected reduction in total triglyceride (TG), but also demonstrated that n3-PUFA supplementation reduced very low-density lipoprotein (VLDL) particle number, modestly increased high-density lipoprotein (HDL) cholesterol, and shifted the composition of HDL subclasses. Further metabolite profiling by 1H-NMR and mass spectrometry revealed pronounced changes in phospholipids, cholesterol esters, diglycerides, and triglycerides following n3-PUFA supplementation. Furthermore, significant changes in hydroxyproline, kynurenine, and 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid (CMPF) following n3-PUFA supplementation provide further insight into some less well-recognized biological effects of n3-PUFA supplementation, including possible effects on protein metabolism, the kynurenine pathway, and glucose metabolism.

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“…Gomes et al triggered inflammation through the administration of lipopolysaccharide (LPS) to mice, resulting in an increase in kynurenine and tryptophan. The increase of kynurenine and tryptophan was attenuated by EPA and DHA treatment, which also contributed to the decrease of inflammatory biomarkers [ 67 ]. These results may explain our findings regarding the increased level of KYNU in the group of higher DNA damage and lower levels of n-3 PUFA (cluster 2) compared with the cluster 1, demonstrating a potential protective effect of DHA and EPA against DNA damage mediated in part by the kynurenine pathway.…”

Section: Discussionmentioning

confidence: 99%

DNA Damage, n-3 Long-Chain PUFA Levels and Proteomic Profile in Brazilian Children and Adolescents

et al. 2021

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Fatty acids play a significant role in maintaining cellular and DNA protection and we previously found an inverse relationship between blood levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and DNA damage. The aim of this study was to explore differences in proteomic profiles, for 117 pro-inflammatory proteins, in two previously defined groups of individuals with different DNA damage and EPA and DHA levels. Healthy children and adolescents (n = 140) aged 9 to 13 years old in an urban area of Brazil were divided by k-means cluster test into two clusters of DNA damage (tail intensity) using the comet assay (cluster 1 = 5.9% ± 1.2 and cluster 2 = 13.8% ± 3.1) in our previous study. The cluster with higher DNA damage and lower levels of DHA (6.2 ± 1.6 mg/dL; 5.4 ± 1.3 mg/dL, p = 0.003) and EPA (0.6 ± 0.2 mg/dL; 0.5 ± 0.1 mg/dL, p < 0.001) presented increased expression of the proteins CDK8–CCNC, PIK3CA–PIK3R1, KYNU, and PRKCB, which are involved in pro-inflammatory pathways. Our findings support the hypothesis that low levels of n-3 long-chain PUFA may have a less protective role against DNA damage through expression of pro-inflammatory proteins, such as CDK8–CCNC, PIK3CA–PIK3R1, KYNU, and PRKCB.

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Fish oil ameliorates sickness behavior induced by lipopolysaccharide in aged mice through the modulation of kynurenine pathway

Cited by 22 publications

References 55 publications

Association between Postpartum Nutritional Status and Postpartum Depression Symptoms

Association between Postpartum Nutritional Status and Postpartum Depression Symptoms

Distinct Influence of Omega-3 Fatty Acids on the Plasma Metabolome of Healthy Older Adults

DNA Damage, n-3 Long-Chain PUFA Levels and Proteomic Profile in Brazilian Children and Adolescents

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