Fish intake, mercury, long-chain <i>n</i>-3 polyunsaturated fatty acids and risk of stroke in northern Sweden

Wennberg, Maria; Bergdahl, Ingvar A.; Stegmayr, Birgitta; Hallmans, Göran; Lundh, Thomas; Skerfving, Staffan; Strömberg, Ulf; Vessby, Bengt; Jansson, Jan‐Håkan

doi:10.1017/s0007114507756519

Cited by 68 publications

(87 citation statements)

References 27 publications

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“…Few prior studies have investigated the relationships between consumption of different types of fish meals and risk of stroke. 4,39 We did not find any beneficial associations between fried fish consumption and subclinical brain abnormalities, in accordance with previous studies of fried fish intake and risk of ischemic stroke and CHD. 4,16 In contrast to tuna or other broiled or baked fish meals, the types of fish used in fried fish meals, such as fish burgers or fish sticks, are typically low in EPAϩDHA, as supported by the lack of association of fried fish intake with blood levels of these fatty acids.…”

Section: Figure 2 White Matter Grades According To Fish Consumptionsupporting

confidence: 91%

Fish consumption and risk of subclinical brain abnormalities on MRI in older adults

Virtanen

Siscovick²,

Longstreth

et al. 2008

Neurology

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Objective: To investigate the association between fish consumption and subclinical brain abnormalities. Methods:In the population-based Cardiovascular Health Study, 3,660 participants age Ն65 underwent an MRI scan in 1992-1994. Five years later, 2,313 were scanned. Neuroradiologists assessed MRI scans in a standardized and blinded manner. Food frequency questionnaires were used to assess dietary intakes. Participants with known cerebrovascular disease were excluded from the analyses. Results:After adjustment for multiple risk factors, the risk of having one or more prevalent subclinical infarcts was lower among those consuming tuna/other fish Ն3 times/week, compared to Ͻ1/month (relative risk 0.74, 95% CI ϭ 0.54 -1.01, p ϭ 0.06, p trend ϭ 0.03). Tuna/other fish consumption was also associated with trends toward lower incidence of subclinical infarcts. Additionally, tuna/other fish intake was associated with better white matter grade, but not with sulcal and ventricular grades, markers of brain atrophy. No significant associations were found between fried fish consumption and any subclinical brain abnormalities. Conclusions:Among older adults, modest consumption of tuna/other fish, but not fried fish, was associated with lower prevalence of subclinical infarcts and white matter abnormalities on MRI examinations. Our results add to prior evidence that suggest that dietary intake of fish with higher eicosapentaenoic acid and docosahexaenoic acid content, and not fried fish intake, may have clinically important health benefits. Neurology ® 2008;71:439-446 GLOSSARY ARR ϭ absolute risk reduction; BMI ϭ body mass index; CHD ϭ coronary heart disease; CHS ϭ Cardiovascular Health Study; DHA ϭ docosahexaenoic acid; EPA ϭ eicosapentaenoic acid; FFQ ϭ food frequency questionnaire; HDL-C ϭ high-density lipoprotein cholesterol; LDL-C ϭ low-density lipoprotein cholesterol; PUFA ϭ polyunsaturated fatty acid; RR ϭ relative risk.Clinically unrecognized or "silent" brain infarcts are very common, particularly with advancing age. Among adults age Ն65 without infarcts on initial brain MRI, nearly 20% had at least one new infarct when MRI was performed about 5 years later, but without recognized TIA or clinical stroke in nearly 90% of cases.1 Persons with MRI-defined infarcts experience greater cognitive decline than persons without infarcts, and such individuals are also at higher risk of future clinical stroke.

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Section: Figure 2 White Matter Grades According To Fish Consumptionsupporting

confidence: 91%

Fish consumption and risk of subclinical brain abnormalities on MRI in older adults

Virtanen

Siscovick²,

Longstreth

et al. 2008

Neurology

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“…Fish samples are commonly used as an indicator of Hg exposure (Dabeka et al 2003(Dabeka et al , 2004Thom et al 2006;Konig et al 2005;Virtanen et al 2005;Wennberg et al 2007;Yoshizawa et al 2002;D'Itri and D'Itri 1975).…”

Section: Introductionmentioning

confidence: 99%

Influence of mining related activities on levels of mercury in water, sediment and fish from the Ankobra and Tano River basins in South Western Ghana

Asare-Donkor

Adimado

2016

Environ Syst Res

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Background: Mercury (Hg) used in gold amalgamation is a major source of contamination in developing countries. The present study evaluates the concentrations of total mercury in water, sediment and fish from the Ankobra and Tano Rivers, which drain the major gold mining areas in Ghana. Total mercury (T-Hg) analysis was carried out using an atomic absorption spectroscopy (Perkin Elmer model 5100PC) equipped with a flow injection analysis system (FIAS, AS-90). Results:Water, sediment and fish T-Hg concentrations were 0.145-1.078 μg/L, 23.39-73.31, and 0.03-0.443 μg/g dw, respectively in Ankobra basin, while in Tano basin levels of 0.214-0.250 μg/L, 14.43-21.51, 0.068-0.413 μg/g were found for water, sediment and fish, respectively. The T-Hg concentration in water from both basins were within the World Health Organization threshold limits for drinking water except at River Asuo Kofi. Concentration of T-Hg in the sediment exceeded Environmental Protection Agency ecotoxicological threshold in some sampling stations, suggesting potential adverse ecological effects. T-Hg levels in fish from both basins were lower than the WHO value (<0.500 μg/g (wet wt). The target hazard quotient values, suggest that human should minimizing meals/week of the analyzed species to avoid deleterious effect during lifetime. Conclusions:The results suggested that mining activities significantly contribute to the considerable environmental Hg contamination in both Ankobra and Tano River basins. Therefore Hg levels should carefully monitored and controlled to reduce its inputs and mitigate potential health consequences of Hg accumulation in the environment.

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“…The FFQ is also used in the Northern Sweden WHO MONICA (Multinational Monitoring of Trends and Determinants in Cardiovascular Disease) studies (5) . Thus, several nested prospective cohort and case-control studies have used this FFQ to investigate various aspects of dietary intake (6)(7)(8)(9)(10) , and others are planned for the future.…”

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confidence: 99%

Evaluation of relative intake of fatty acids according to the Northern Sweden FFQ with fatty acid levels in erythrocyte membranes as biomarkers

Wennberg

Vessby

Johansson

2009

Public Health Nutr.

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Objective: To evaluate the validity of the Northern Sweden eighty-four-item FFQ to estimate intake of fatty acids relative to 24 h diet recalls (24-HDR) and fatty acids in erythrocyte membranes. Design: Participants, randomly recruited from the population-based Västerbotten Intervention Project, answered the eighty-four-item FFQ. During the following year each participant carried out ten 24-HDR. Intake of fatty acids measured by the FFQ was compared with intake by the 24-HDR and fatty acid levels in erythrocytes. Setting: The county of Västerbotten in northern Sweden. Subjects: Ninety-six men and ninety-nine women. Results: Spearman correlation coefficients (r s ) between intakes of the fatty acids 14 : 0, 15 : 0, 16 : 0, 17 : 0, 18 : 2n-6, 18 : 3n-3, 20 : 5n-3 and 22 : 6n-3 estimated by the FFQ and the 24-HDR were all significant and ranged from 0?29 (22 : 6n-3 in men and women) to 0?60 (16 : 0 in men), whereas significant correlations between FFQ-estimated intake and erythrocyte membrane content were only seen for milk fatty acids 14 : 0, 15 : 0 and 17 : 0 (r s 5 0?23-0?34) and fish fatty acids 20 : 5n-3 and 22 : 6n-3 (r s 5 0?42-0?51). Conclusion: The Northern Sweden eighty-four-item FFQ gives a satisfactory estimate of the intake of fish fatty acids (20 : 5n-3 and 22 : 6n-3) and milk fatty acids (15 : 0 and 17 : 0), whereas its validity for fatty acids 18 : 2n-6 and 18 : 3n-3, derived mainly from vegetable oils, cannot be shown.

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Fish intake, mercury, long-chain n-3 polyunsaturated fatty acids and risk of stroke in northern Sweden

Cited by 68 publications

References 27 publications

Fish consumption and risk of subclinical brain abnormalities on MRI in older adults

Fish consumption and risk of subclinical brain abnormalities on MRI in older adults

Influence of mining related activities on levels of mercury in water, sediment and fish from the Ankobra and Tano River basins in South Western Ghana

Evaluation of relative intake of fatty acids according to the Northern Sweden FFQ with fatty acid levels in erythrocyte membranes as biomarkers

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