Fish Consumption, n-3 Fatty Acids in Cell Membranes, and Heart Rate Variability in Survivors of Myocardial Infarction With Left Ventricular Dysfunction

Christensen, Jeppe Hagstrup; Korup, Eva; Aarøe, Jens; Toft, Egon; Møller, Jesper M.; Rasmussen, Klaus; Dyerberg, Jørn; Schmidt, Erik Berg

doi:10.1016/s0002-9149(97)00220-8

Cited by 158 publications

(102 citation statements)

References 20 publications

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“…The n-6/n-3 PUFA ratio was significantly reduced in the treatment group from 1.12 to 3.48. As noted in other series [67,68], the reduction in plasma levels of catecholamines and cytokines, in addition to increased HRV, were related to the increase in concentrations of EPA and DHA, confirming the impact of n-3 PUFAs on important pathogenic mechanisms of arrhythmias in nonischemic HF patients.…”

Section: Antiarrhythmic Effectssupporting

confidence: 81%

Effects of supplementation with polyunsaturated fatty acids in patients with heart failure

et al. 2011

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Despite the clinical and prognostic improvement obtained with the current medical treatment, heart failure (HF) continues to have high morbidity and mortality and its prevalence is increasing in most regions of the world. Thus, there is a need for novel adjunctive therapies that act independently of current neurohormonally and haemodynamically oriented drugs. Nutritional approaches are particularly attractive because they could work additively with established therapies without negative hemodynamic effects. There is growing evidence that omega-3 polyunsaturated fatty acids (n-3 PUFAs) supplementation positively impacts established pathophysiological mechanisms in HF and thus has a potential role for preventing and treating HF. The results of the GISSI-HF trial have indicated that, in patients with chronic HF on evidence-based therapy, long term treatment with PUFAs reduced mortality and hospitalizations for cardiovascular reasons, irrespective of etiology and left ventricular (LV) ejection fraction (EF). The purpose of this review is to summarize the evidence emerged from studies conducted so far on the effect of n-3 PUFAs in HF.

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Section: Antiarrhythmic Effectssupporting

confidence: 81%

Effects of supplementation with polyunsaturated fatty acids in patients with heart failure

et al. 2011

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“…Epidemiological data supports potent cardioprotective actions of EPA/DHA [107]. Intervention studies in populations at risk of CHD support the conclusion that low levels of daily EPA/DHA are sufficient to protect against CHD [12,37,106], and there is some data to support the view that this reflects anti-arrythmic effects of dietary omega-3 PUFA [20,106]. The strength of the data has led to a widespread consensus that there should be modest increases in omega-3 PUFA intake (either as ALNA and/or EPA/DHA) and this has provided the basis for the formal recommendations made by a number of expert bodies [11,22,26,34].…”

Section: Metabolic Effects Of Alpha Linolenic Acidmentioning

confidence: 96%

Dietary fatty acids and human health

Williams¹

2000

Ann. Zootech.

528

374

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-A considerable amount of evidence has accumulated to support the view that the very long chain omega 3 fatty acids (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) have beneficial cardiovascular and anti-inflammatory properties and that levels of their consumption are insufficient in most Western diets. More recently, attention has been given to the possibility that the precursor omega-3 PUFA, alpha linolenic acid (ALNA), may share some of the beneficial actions of EPA/DHA on human health. Further research into the metabolism and physiological actions of ALNA, and comparisons with EPA/DHA, is needed before conclusions regarding the optimal amounts and types of omega-3 PUFA for human health can be defined. Conjugated linoleic acid (CLA), which arises as a metabolic by-product of rumen hydrogenation and which is found in foods of animal origin, has been proposed to possess potent health promoting properties, but much of this research has been conducted in experimental animals. There is an urgent need for complementary studies in human volunteers, to confirm the putative anti-carcinogenic, anti-atherogenic, anti-lipogenic and immuno-suppressive properties of CLA.human health / fatty acids / omega-3 PUFA / conjugated linoleic acid Résumé -Acides gras alimentaires et santé humaine. Il a été amplement démontré que les acides gras à très longue chaîne en oméga 3, les acides eicoapentaenoïque (EPA) et decosahexaenoïque (DHA) ont des effets positifs relatifs à l'apparition des maladies cardio-vasculaires, et des propriété anti-inflammatoires. Leur consommation par l'Homme est insuffisante dans la plupart des pays occidentaux. Récemment il est apparu que l'acide alpha linolénique, précurseur des acides gras en oméga 3, pouvait partager avec l'EPA et le DHA certains effets positifs sur la santé humaine. Des recherches complémentaires sur le métabolisme et le rôle physiologique de l'acide alpha linolénique, ainsi que des comparaisons avec l'EPA et le DHA sont nécessaires avant de pouvoir définir les apports recommandés optimaux de chacun de ces acides gras. L'acide linoléique conjugué (CLA) qui provient du métabolisme ruminal des acides gras et qui est présent dans les aliments d'origine animale, a été décrit comme potentiellement favorable à la santé humaine, mais la plupart des expérimentations ont été conduites sur animaux de laboratoire. Il y a une urgence à réaliser des études complémentaires sur des volontaires humains, afin de confirmer les propriétés annoncées du CLA, à savoir des effets anti-carcinogène, anti-athérogène, anti-lipogénique et une modulation de l'immunité. santé humaine / acides gras / oméga-3 PUFA / acide linoléique conjugué

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“…Effects on ion channels play a role. Epidemiological and clinical studies also suggest antiarrhythmic effects from the consumption of ®sh and marine n-3 PUFA (Siscovick et al, 1996;Christensen et al, 1997;Singh et al, 1997). The evidence warrants controlled clinical trials on the effect of marine n-3 PUFA on ventricular ®brillation (the main cause of sudden death from acute heart attacks).…”

Section: What Is the Outcome On Arrhythmias?mentioning

confidence: 99%

Health aspects of fish and n-3 polyunsaturated fatty acids from plant and marine origin

et al. 1998

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Fish Consumption, n-3 Fatty Acids in Cell Membranes, and Heart Rate Variability in Survivors of Myocardial Infarction With Left Ventricular Dysfunction

Cited by 158 publications

References 20 publications

Effects of supplementation with polyunsaturated fatty acids in patients with heart failure

Effects of supplementation with polyunsaturated fatty acids in patients with heart failure

Dietary fatty acids and human health

Health aspects of fish and n-3 polyunsaturated fatty acids from plant and marine origin

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