Fish consumption and risk of depression: a meta-analysis

Li, Fang; Liu, Xiaoqin; Zhang, Dongfeng

doi:10.1136/jech-2015-206278

Cited by 154 publications

(120 citation statements)

References 35 publications

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“…A first hint of this inverse association was provided in 1998 by ecological evidence showing a lower prevalence of psychiatric disorders in countries where more (fatty) fish is being consumed, the main dietary source of fatty acids (Hibbeln 1998;Hibbeln 2002;Grosso et al 2014). Later, more detailed cross-sectional studies largely supported this ecological evidence (Grosso et al 2016;Li et al 2016). In addition, prospective studies generally also corroborated this relationship (Sanhueza et al 2013;Vermeulen et al 2016), providing further support for a possible causal relationship.…”

Section: Epidemiological Evidencementioning

confidence: 99%

Focus on fatty acids in the neurometabolic pathophysiology of psychiatric disorders

Mocking

Assies

Ruhé

et al. 2018

J of Inher Metab Disea

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Continuous research into the pathophysiology of psychiatric disorders, such as major depressive disorder (MDD), posttraumatic stress disorder (PTSD), and schizophrenia, suggests an important role for metabolism. This narrative review will provide an upto-date summary of how metabolism is thought to be involved in the pathophysiology of these psychiatric disorders. We will focus on (I) the important role of fatty acids in these metabolic alterations, (II) whether fatty acid alterations represent epiphenomena or risk factors, and (III) similarities and dissociations in fatty acid alterations between different psychiatric disorders. (Historical) epidemiological evidence links fatty acid intake to psychiatric disorder prevalence, corroborated by altered fatty acid concentrations measured in psychiatric patients. These fatty acid alterations are connected with other concomitant pathophysiological mechanisms, including biological stress (hypothalamic-pituitary-adrenal (HPA)-axis and oxidative stress), inflammation, and brain network structure and function. Metabolomics and lipidomics studies are underway to more deeply investigate this complex network of associated neurometabolic alterations. Supplementation of fatty acids as disease-modifying nutraceuticals has clinical potential, particularly add-on eicosapentaenoic acid (EPA) in depressed patients with markers of increased inflammation. However, by interpreting the observed fatty acid alterations as partly (mal)adaptive phenomena, we attempt to nuance translational expectations and provide new clinical applications for these novel neurometabolic insights, e.g., to predict treatment response or depression recurrence. In conclusion, placing fatty acids in context can contribute to further understanding and optimized treatment of psychiatric disorders, in order to diminish their overwhelming burden of disease.

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Section: Epidemiological Evidencementioning

confidence: 99%

Focus on fatty acids in the neurometabolic pathophysiology of psychiatric disorders

Mocking

Assies

Ruhé

et al. 2018

J of Inher Metab Disea

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show abstract

“…29 Fish consumption may also be protective against depression according to the results of a meta-analysis of 26 epidemiologic studies. 30 The benefit of fish may be due to the greater intake of the long-chain omega-3 fatty acids since eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may exert anti-inflammatory effects 31 and some evidence indicates that inflammation is involved in the etiology of depression, although the exact role of and mechanisms associated with inflammation remain to be determined. 32-34 Interestingly, a recent Japanese cross-sectional study found that even among a population with higher blood levels of long-chain omega-3 fatty acids, serum levels of EPA and DHA were inversely associated with depressive symptoms in community dwellers.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the potential antidepressant effects of soybean isoflavones

Messina

Gleason²

2016

Menopause

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Objective To determine whether isoflavones affect depressive symptoms in women. Methods Literature searches were conducted to identify clinical and epidemiologic studies that evaluated the impact of soy intake and isoflavone exposure on depressive symptoms. References from identified studies were also evaluated to identify eligible studies. Results Only limited epidemiologic research has evaluated the impact of soy or isoflavone intake on depression although several studies from China and Japan did find soy product intake was inversely related to risk of depression. However, often times, soy was evaluated only as a component of a summative dietary pattern (e.g., a “Japanese” or “Healthy” diet). Of the 20 intervention studies identified, roughly half found statistically significant reductions in depressive symptoms in response to isoflavones although several had design weakness. Of those studies reporting a lack of antidepressant effects of isoflavones, design limitations likely contributed to the lack of efficacy. In all but two trials, assessment of depression was, however, a secondary outcome. It is notable that both trials in which depression was a primary outcome found isoflavones significantly improved symptoms. Conclusions Although the data are inconsistent and limited, the clinical and epidemiologic evidence suggests that isoflavones may offer a safe, well-tolerated option for management of depression. Furthermore, the intervention doses used in the clinical studies fall well within the dietary range. The extant literature reveals key design features for future studies, which based upon the results of this review, are clearly warranted.

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“…The association between fish consumption specifically and risk of depression was recently reviewed with results from a meta-analysis concluding that high fish consumption was associated with reduced risk of depression, the pooled risk ratio of depression for the highest versus lowest consumption of fish being 0.83 (95% CI 0.74 to 0.93) [58]. However, when studies were separated by continent, not all followed the same pattern; there were significant associations in studies conducted in Europe but not in those conducted in North America, South America, Asia and Oceania.…”

Section: Discussionmentioning

confidence: 99%

There is No Association Between the Omega-3 Index and Depressive Symptoms in Patients With Heart Disease Who Are Low Fish Consumers

Cai

Coates

Buckley

et al. 2017

Heart, Lung and Circulation

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Fish consumption and risk of depression: a meta-analysis

Abstract: This meta-analysis indicates that high-fish consumption can reduce the risk of depression.

Cited by 154 publications

References 35 publications

Focus on fatty acids in the neurometabolic pathophysiology of psychiatric disorders

Focus on fatty acids in the neurometabolic pathophysiology of psychiatric disorders

Evaluation of the potential antidepressant effects of soybean isoflavones

There is No Association Between the Omega-3 Index and Depressive Symptoms in Patients With Heart Disease Who Are Low Fish Consumers

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