Fish Consumption and Depressive Symptoms in the General Population in Finland

Tanskanen, Antti; Hibbeln, Joseph R.; Tuomilehto, Jaakko; Uutela, Antti; Haukkala, Ari; Viinamäki, Heimo; Lehtonen, Johannes; Vartiainen, Erkki

doi:10.1176/appi.ps.52.4.529

Cited by 310 publications

(209 citation statements)

References 10 publications

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“…A recent population-based cross-sectional study nested to the ATBC study showed no association between the intake of omega-3 FAs and depression in Finnish males (Hakkarainen et al, 2004). Besides, the other Finnish study reported a significant association between the frequency of fish intake and depression in females, but not in males (Tanskanen et al, 2001). These studies suggested the possibility that there may be no relation between omega-3 FAs and depression in males, which is consistent with our results.…”

Section: Serum Fatty Acid and Depression In Cancer Patients M Kobayaksupporting

confidence: 90%

Levels of omega-3 fatty acid in serum phospholipids and depression in patients with lung cancer

et al. 2005

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Previous studies suggested that omega-3 fatty acids (FAs) have therapeutic effects against depression, but there is no evidence in the oncological setting. Our preliminary study reported the association between lower omega-3 FA intake and occurrence of depression in lung cancer patients. To explore the association further, the present study examined whether depression was associated with lower levels of omega-3 FAs in serum phospholipids. A total of 717 subjects in the Lung Cancer Database Project were divided into three groups by two cutoff points of the Hospital Anxiety and Depression Scale depression subscale (HADS-D). In all, 81 subjects of the nondepression and minor depression groups (HADS-Do5 and 5pHADS-Dp10, respectively) were selected to match with 81 subjects of the major depression group (HADS-D410) for age, gender, clinical stage, and performance status. Fatty acids were assayed by gas chromatography and compared among the three matched groups. There were no differences between the major depression group and nondepression group in any FAs. The minor depression group had higher mean levels of docosahexaenoic acid (mean7s. Major and minor depressions are one of the most common psychiatric problems in clinical oncological settings (Derogatis et al, 1983;Razavi and Stiefel, 1994;McDaniel et al, 1995). Docosahexaenoic acid (DHA), one of the omega-3 fatty acids (FAs), is a major component of membrane FAs in brain neural cells and lack of DHA has been shown to alter neural transmission in animal studies (Bruinsma and Taren, 2000;Innis, 2000;Ng and Innis, 2003). Previous studies have shown associations between DHA or its precursor, eicosapentaenoic acid (EPA, omega-3 FA), and major depression in subjects without cancer (Edwards et al, 1998;Hibbeln, 1998;Peet et al, 1998;Maes et al, 1999). Other studies have shown their possible therapeutic potential with few adverse effects in clinical trials (Nemets et al, 2002;Peet and Horrobin, 2002;Su et al, 2003). In the oncological setting, the use of antidepressants has been limited due to their adverse effects (Akizuki et al, 2002;Fisch, 2004). In our previous pilot study to obtain information for planning interventional research, depression in cancer patients was not associated with either EPA or DHA intakes, but was associated with lower intake of alpha-linolenic acid (ALA: major omega-3 FAs in diet, precursor of EPA and DHA) (Suzuki et al, 2004). To elucidate any such association in detail, the present study was designed to examine our hypothesis that lower levels of omega-3 FAs (EPA, DHA) in serum phospholipids are associated with major and minor depression in lung cancer patients. MATERIALS AND METHODS Study design and subjectsThe present study was a three matched group case -control study, based in part on the Lung Cancer Database Project, which was a prospective cohort study for investigation of the pathogenesis of and development of new therapy for lung cancer at the National Cancer Center Hospital East and the National Cancer Center Research Institute East, ...

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Section: Serum Fatty Acid and Depression In Cancer Patients M Kobayaksupporting

confidence: 90%

Levels of omega-3 fatty acid in serum phospholipids and depression in patients with lung cancer

et al. 2005

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“…Another possible reason for the discrepancy in findings is that the characteristics of depression in this study may differ from those of previous studies. Previous epidemiological research examined the prevalence of depression in the general population (Hibbeln, 1998;Tanskanen et al, 2001), while we examined depression among a population that was subjected to the stress of having recently been diagnosed with lung cancer. Thus, differences in the situations of the subjects may have caused the inconsistent findings.…”

Section: Discussionmentioning

confidence: 99%

“…Epidemiological findings linking depression and low levels of fish intake have been reported (Hibbeln, 1998;Tanskanen et al, 2001), and biochemical research has also shown that the concentrations of each o-3 FA are significantly lower in the serum or red blood cell membranes of depressed patients than in control subjects (Edwards et al, 1998;Peet et al, 1998;Maes et al, 1999). Ethyl-EPA augmentation therapy has been reported to improve depressive symptoms in patients with major depression in randomised placebo-controlled double-blind clinical trials (Nemets et al, 2002;Peet and Horrobin, 2002) and in one clinical report (Puri et al, 2002).…”

mentioning

confidence: 98%

Daily omega-3 fatty acid intake and depression in Japanese patients with newly diagnosed lung cancer

et al. 2004

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The aim of the present study was to examine the association between daily omega-3 fatty acid intake and depression in Japanese cancer patients. Omega-3 fatty acid intake in 771 patients with newly diagnosed primary lung cancer was evaluated using a foodfrequency questionnaire, and the prevalence of depression was examined using the cutoff values for the depression subscale included in the Hospital Anxiety and Depression Scale. After adjustment for potential confounding factors, the odds ratio (OR) for depression among patients in the highest quartile of the total eicosapentaenoic acid-(C20:5n-3) and docosapentaenoic acid (C22:6n-3)-intake group compared with patients in the lowest quartile was not significantly different. On the other hand, the OR among the highest quartile of a-linolenic acid (C18:3n-3) intake (adjusted OR ¼ 0.50, 95% CI: 0.31 -0.71, P for trend ¼ 0.004) and the highest quartile of total omega-3 fatty acid intake (adjusted OR ¼ 0.55, 95% CI: 0.35 -0.88, P for trend ¼ 0.022) were significantly different. These results suggest that total eicosapentaenoic acid and docosapentaenoic acid intake might not be associated with depression in Japanese patients with newly diagnosed lung cancer, but that a-linolenic acid intake and total omega-3 fatty acid intake might be.

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“…There was a low proportion eating fish less than once weekly in our sample. Weekly fish eating has previously been found to be associated with lower psychological distress/depression (19,20) , therefore we chose to dichotomise the FFQ data for fish at , 1 portion/week v. $1 portion/week. In our study, fish consumption was found to be significantly associated with reduced distress by approximately 50 % in both men and women.…”

Section: Fish and Common Mental Disordermentioning

confidence: 99%

Psychological distress, gender and dietary factors in South Asians: a cross-sectional survey

Bhattacharyya

Marston

Walters

et al. 2013

Public Health Nutr.

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Objective: Psychological distress, defined as symptoms of depression and anxiety, is an increasingly important public health issue in developing countries. Little is known about the extent to which adverse dietary factors are associated with psychological distress in South Asians. Our aim was to compare the associations of diet and psychological distress in men and women in Goa, India. Design: Cross-sectional study of consecutive attendees in nine urban and rural general practices in Goa, India in 2004-2005. All participants completed an FFQ on their dietary intake in a typical week. Psychological distress was measured using the Kessler Psychological Distress Scale (K10), a WHO-validated screening instrument. Results: Consecutive attendees (n 1512; 601 men and 911 women) aged 30 to 75 years participated. Moderate and high scores of psychological distress were detected in significantly more women than men (eighty-eight men v. 264 women, unadjusted OR 5 0?39; 95 % CI 0?29, 0?52). Those who ate one or more portions of fish weekly had nearly half the prevalence of distress in both sexes (women, OR 5 0?52; 95 % CI 0?29, 0?91; men, OR 5 0?50; 95 % CI 0?25, 0?99) and this was independent of age, marital status, education, income, religion and living alone. Conclusions: Psychological distress is significantly lower with fish intake in both sexes. Further longitudinal work is needed to establish temporal relationships. Addressing psychological distress is becoming an increasingly significant public health priority in both high-and low-income countries.

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Fish Consumption and Depressive Symptoms in the General Population in Finland

Cited by 310 publications

References 10 publications

Levels of omega-3 fatty acid in serum phospholipids and depression in patients with lung cancer

Levels of omega-3 fatty acid in serum phospholipids and depression in patients with lung cancer

Daily omega-3 fatty acid intake and depression in Japanese patients with newly diagnosed lung cancer

Psychological distress, gender and dietary factors in South Asians: a cross-sectional survey

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