Fisetin induces G2/M phase arrest and caspase‐mediated cleavage of p21Cip1 and p27Kip1 leading to apoptosis and tumor growth inhibition in HNSCC
Monika Yadav,
Kushal Kandhari,
Sivapar V. Mathan
et al.
Abstract:The anticancer potential and associated mechanisms of flavonoid fisetin are yet to be fully investigated on human head and neck squamous cell carcinoma (HNSCC). In the present study, fisetin (25‐75 µM for 24–48 h) dose‐dependently inhibited growth and induced death in HNSCC Cal33 and UM‐SCC‐22B cells, without showing any death in normal cells. Fisetin (25–50 µM) induced G2/M phase arrest via decrease in Cdc25C, CDK1, cyclin B1 expression, and an increase in p53(S15). A concentration‐dependent increase in fiset… Show more
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