Fisetin and Its Role in Chronic Diseases

Pal, Harish C.; Pearlman, Ross L; Afaq, Farrukh

doi:10.1007/978-3-319-41334-1_10

Cited by 84 publications

(72 citation statements)

References 119 publications

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“…It also represents antiviral function (Zakaryan et al, 2017). Fisetin is a commercially available nutraceutical with anti-inflammatory, antioxidant, anti-tumorigenic, anti-invasive, anti-angiogenic, anti-diabetic, neuroprotective and cardioprotective effects (Pal, Pearlman, & Afaq, 2016). Interestingly, fisetin has an anti-noroviral activity by inducing cytokines (Seo & Choi, 2017).…”

Section: Discussionmentioning

confidence: 99%

Characteristics of flavonoids as potent MERS‐CoV 3C‐like protease inhibitors

et al. 2019

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Middle East respiratory syndrome‐coronavirus (MERS‐CoV) is a zoonotic virus transmitted between animals and human beings. It causes MERS with high mortality rate. However, no vaccine or specific treatment is currently available. Since antiviral activity of some flavonoids is known, we applied a flavonoid library to probe inhibitory compounds against MERS‐CoV 3C‐like protease (3CLpro). Herbacetin, isobavachalcone, quercetin 3‐β‐d‐glucoside and helichrysetin were found to block the enzymatic activity of MERS‐CoV 3CLpro. The binding of the four flavonoids was also confirmed independently using a tryptophan‐based fluorescence method. The systematic comparison of the binding affinity of flavonoids made it possible to infer their scaffolds and functional groups required to bind with MERS‐CoV 3CLpro. An induced‐fit docking analysis revealed that S1 and S2 sites play a role in interaction with flavonoids. The experimental and computational study showed that flavonol and chalcone are favourite scaffolds to bind with the catalytic site of MERS‐CoV 3CLpro. It was also deduced that some flavonoid derivatives with hydrophobic or carbohydrate attached to their core structures have a good inhibitory effect. Therefore, we suggest that flavonoids with these characteristics can be used as templates to develop potent MERS‐CoV 3CLpro inhibitors.

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Section: Discussionmentioning

confidence: 99%

Characteristics of flavonoids as potent MERS‐CoV 3C‐like protease inhibitors

et al. 2019

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“…Red-colored foods tend to be high in certain (phyto)nutrients that may confer antioxidant, anti-inflammatory, and immune-modulating activities such as ascorbic acid, lycopene, astaxanthin, fisetin, and the wider class of anthocyanins. Chronic inflammation is closely associated with a dysfunctional and dysregulated immune response, ultimately resulting in a wide variety of conditions such as cancers, neurological abnormalities, cardiovascular diseases, diabetes, obesity, pulmonary diseases, immunological diseases, and other life-threatening conditions [51].…”

Section: Red Foods and Inflammationmentioning

confidence: 99%

A Review of the Science of Colorful, Plant-Based Food and Practical Strategies for “Eating the Rainbow”

Minich

2019

Journal of Nutrition and Metabolism

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Over the past decades, thousands of published studies have amassed supporting recommendations to consume fruits and vegetables for physiological and psychological health. Newer research has emerged to suggest that these plant-based foods contain a plethora of not only vitamins and minerals, but perhaps, most importantly, phytonutrients. These phytonutrients have known pleiotropic effects on cellular structure and function, ultimately resulting in the modulation of protein kinases and subsequent epigenetic modification in a manner that leads to improved outcomes. Even though eating fruits and vegetables is a well-known feature of a healthy dietary pattern, population intakes continue to be below federal recommendations. To encourage consumers to include fruits and vegetables into their diet, an “eat by color” approach is proposed in this review. Although each individual food may have numerous effects based on its constituents, the goal of this simplified approach was to identify general patterns of benefits based on the preponderance of scientific data and known mechanisms of food-based constituents. It is suggested that such a consumer-oriented categorization of these plant-based foods may lead to greater recognition of their importance in the daily diet throughout the lifespan. Other adjunctive strategies to heighten awareness of fruits and vegetables are discussed.

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“…Fisetin, a flavonol present in strawberries, apples, persimmons, onions, kiwi, and cucumbers, has been recently demonstrated to exert not only potent neuroprotective effects but also different anti-tumor activities [33,34]. In PCa, it was shown to specifically bind to the AR LBD.…”

Section: Natural Compounds Modulating the Androgen Receptor Axismentioning

confidence: 99%

Natural Compounds in Prostate Cancer Prevention and Treatment: Mechanisms of Action and Molecular Targets

Fontana

Raimondi

Marzagalli

et al. 2020

Cells

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Prostate cancer (PCa) represents a major cause of cancer mortality among men in developed countries. Patients with recurrent disease initially respond to androgen-deprivation therapy, but the tumor eventually progresses into castration-resistant PCa; in this condition, tumor cells acquire the ability to escape cell death and develop resistance to current therapies. Thus, new therapeutic approaches for PCa management are urgently needed. In this setting, natural products have been extensively studied for their anti-PCa activities, such as tumor growth suppression, cell death induction, and inhibition of metastasis and angiogenesis. Additionally, numerous studies have shown that phytochemicals can specifically target the androgen receptor (AR) signaling, as well as the PCa stem cells (PCSCs). Interestingly, many clinical trials have been conducted to test the efficacy of nutraceuticals in human subjects, and they have partially confirmed the promising results obtained in vitro and in preclinical models. This article summarizes the anti-cancer mechanisms and therapeutic potentials of different natural compounds in the context of PCa prevention and treatment.

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Fisetin and Its Role in Chronic Diseases

Cited by 84 publications

References 119 publications

Characteristics of flavonoids as potent MERS‐CoV 3C‐like protease inhibitors

Characteristics of flavonoids as potent MERS‐CoV 3C‐like protease inhibitors

A Review of the Science of Colorful, Plant-Based Food and Practical Strategies for “Eating the Rainbow”

Natural Compounds in Prostate Cancer Prevention and Treatment: Mechanisms of Action and Molecular Targets

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