First use of the maleamate(−1) ligand in coordination chemistry: Dinuclear copper(II) complexes with N-donors and their interesting ‘organic’ chemistry

Preparation and Study of the Antibacterial Applications and Oxidative Stress Induction of Copper Maleamate-Functionalized Mesoporous Silica Nanoparticles

“…In particular, we became interested in copper(II) maleamates, because of the attractive properties that these kinds of compounds have shown in previous antibacterial studies [39,40,41,42,43]. Although these copper(II) compounds did not show a good degree of stability in physiologic medium, (even though they incorporated auxiliary bipyridine and/or phenanthroline ligands in their structure), they presented a potent antimicrobial activity which needs to be examined in detail.…”

Recent advances in the synthesis and applications of 2,6-dipyrazolylpyridine derivatives and their complexes

“…141 Other polymetallic complexes where a 1-bpp or 3-bpp derivative acts as a simple 15 capping ligand are also known. 52,101,[142][143][144][145][146][147][148][149] Appending extra donor groups onto the 3-bpp skeleton gives further scope for high-nuclearity complex formation. Thus, the diphenoxo derivative L 19 66,72,[163][164][165] None of these studies used a chiral bpp derivative as co-ligand, although those are easily accessible for the 1-bpp series.…”

“…The following have also been prepared: a hexanuclear iron(III) complex 141 Other polymetallic complexes where a 1-bpp or 3-bpp derivative acts as a simple capping ligand are also known. 52,101,[142][143][144][145][146][147][148][149] Appending extra donor groups onto the 3-bpp skeleton gives further scope for high-nuclearity complex formation. Thus, the di-phenoxo derivative L 19 , where iron(II) sites occupy the corners of the grid and the iron(III) ion is at the centre.…”

Copper-functionalized nanostructured silica-based systems: Study of the antimicrobial applications and ROS generation against gram positive and gram negative bacteria

“…In this context, our group recently reported the preparation and study of the antibacterial properties of copper(II) maleamate complexes supported on mesoporous silica nanoparticles (MSN) [21]. Maleamates ligands were chosen because they have a rich coordination chemistry [36][37][38][39][40] and a very high potential to perturb the biological action of the enzyme maleamate amidohydrolase, negatively affecting the bacterial viability [41,42]. In addition, copper ions were used for the preparation of the metal complexes, as copper(II) compounds have a very long tradition in antibacterial studies, demonstrating a very high antimicrobial activity [43][44][45].…”