First urinary tract infection in neonates, infants and young children: a comparative study

Abstract

In an attempt to evaluate first urinary tract infection (UTI) in neonates and infants, we estimated retrospectively in 296 patients (62 neonates and 234 infants) clinical and laboratory findings, occurrence of vesicoureteral reflux (VUR), urinary tract abnormalities and pyelonephritis. First UTI occurred more often in male than female neonates, whereas male and female infants/young children were affected at an equal rate. The pathogens isolated in urine cultures of neonates and infants did not statistically significantly differ (P>0.05); Escherichia coli predominated. Gram-negative bacteria other than E. coli affected boys more often than girls (P=0.0022). Fever was the most frequent symptom. Neonates had lower-grade fever of shorter duration than infants (P<0.05). The incidence of reflux and urinary tract abnormalities did not differ between neonates and infants, male and female neonates and infants (P>0.05). Pyelonephritis affected neonates and infants at an equal rate; it was more prevalent among female patients (P=0.038) and patients with VUR or urinary tract abnormalities other than VUR (P<0.0001). Neonates with reflux were more often affected by Gram-negative bacteria other than E. coli than were neonates without reflux (P=0.0008).

Urinary tract infection in the newborn: clinical and radio imaging studies

“…The mean age at diagnosis was 16 days, which is consistent with data reported by others [7,16]. In agreement with other studies [10,[16][17][18], UTI was significantly more common in males than in females, particularly in patients with nosocomial UTI. The higher prevalence in males has been explained by the presence of phimosis, increased incidence of nephrourological anomalies, and higher susceptibility to infection [19][20][21].…”

Post-Inflammatory Nephropathy

“…However, an association between urinary tract infection in children with vesicoureteral reflux and renal scarring remains unquestionable (Faust et al, 2009;Jahnukainen et al, 2005;Muinuddin et al, 2008). This was confirmed by recent studies that demonstrated an increase in the risk of renal scarring after acute pyelonephritis in patients with vesicoureteral reflux (Kanellopoulos et al, 2006;Lee et al, 2006;Polito et al, 2006;Oh et al, 2008). Studies by Svensson et al (2005) and Mohanan et al (2008) disclosed that renal scarring was detected less frequently in infants with vesicoureteral reflux and without urinary tract infection than in those with vesicoureteral reflux and urinary tract infection.…”

Učestalost i karakteristike infekcija urinarnog trakta kod djece u prvoj godini života hospitalizovane na Klinici za dječje bolesti Banja Luka

“…Kod novorođenčadi se IUT javljaju u 1-2%, a odnos muškog prema ženskom polu u oboljevanju je od 2,8:1 do 5,4:1. Razlog češćeg oboljevanja muške novorođenčadi i dojenčadi treba tražiti u većoj učestalosti kongenitalnih anomalija urotrakta u muške djece [14,15].…”