First trimester serum biomarker discovery study for early onset, preterm onset and preeclampsia at term

Beernink, R.; Zwertbroek, Eva F.; Schuitemaker, Joost H. N.; Cremers, Thomas; Scherjon, Sicco A.

doi:10.1016/j.placenta.2022.08.010

Cited by 9 publications

(7 citation statements)

References 77 publications

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“…Another proteomic study utilizing serum from the first trimester of pregnancy revealed several differentially expressed proteins in SPTB 14 . Among these proteins was CRP which was upregulated in SPTB.…”

Section: Discussionmentioning

confidence: 99%

Maternal serum alpha-1 antitrypsin levels in spontaneous preterm and term pregnancies

Tissarinen,

Tiensuu,

Haapalainen

et al. 2024

Sci Rep

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Currently, there are no accurate means to predict spontaneous preterm birth (SPTB). Recently, we observed low expression of alpha-1 antitrypsin (AAT) in SPTB placentas. Present aim was to compare the concentrations of maternal serum AAT in pregnancies with preterm and term deliveries. Serum C-reactive protein (CRP) was used as a reference inflammatory marker. Two populations were studied. The first population comprised women who eventually gave birth spontaneously preterm (SPTB group) or term (control group). The second population included pregnant women shortly before delivery and nonpregnant women. We observed that serum AAT levels were higher in the SPTB group than in the controls, and a similar difference was observed when serum CRP was considered in multivariable analysis. However, the overlap in the AAT concentrations was considerable. No statistical significance was observed in serum AAT levels between preterm and term pregnancies at delivery. However, AAT levels were higher at delivery compared to nonpregnant controls. We did not observe a strong correlation between serum AAT and CRP in early pregnancy samples and at labor. We propose that during early pregnancy, complicated by subsequent SPTB, modest elevation of serum AAT associates with SPTB.

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Section: Discussionmentioning

confidence: 99%

Maternal serum alpha-1 antitrypsin levels in spontaneous preterm and term pregnancies

Tissarinen,

Tiensuu,

Haapalainen

et al. 2024

Sci Rep

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“…Recognizing these early signs can lead to early intervention and treatment on behalf of the mother-neonate dyad, potentially enhancing outcomes. 17,18…”

Section: Funding the Author(s) Received No Specific Grant Or Financia...mentioning

confidence: 99%

Recognizing Early Warning Signs of Acute Hypertensive Crisis of the Postpartum Mother: An Important Role for Neonatal Nurses

Fant,

Rhoads,

Tucker

2023

Neonatal Network

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A delay in detecting acute hypertensive crisis in postpartum mothers can exacerbate complications in the mother. Neonatal nurses are uniquely qualified to identify postpartum warning signs in mothers while they are in the NICU with their infants. Few research studies have explored the use of neonatal nurse screenings for acute hypertensive crisis in postpartum mothers. NICU nurses screening mothers for postpartum depression has yielded success in improving outcomes, and this model could be translated into screening for acute hypertensive crisis. Further education should be implemented for NICU nurses that include a review of adult blood pressure monitoring, early warning signs, and symptoms of preeclampsia that the mother should report. This article discusses the importance of the neonatal nurse’s role in identifying early warning signs of maternal postpartum hypertensive crisis.

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“…Their regulated secretion from fetal-placental and maternal tissue into the bloodstream supports placental development, implantation, immunotolerance and fetal growth (Baud and Berkane 2019). Importantly, perturbations in these physiological processes can lead to conditions such as preeclampsia, fetal growth restriction and preterm birth, which can arise without clear predictive biomarkers, necessitating extensive research for new biomarkers to enable a more personalised approach to pregnancy care (Beernink et al 2022, Paules et al 2020, D’Silva, Hyett and Coorssen 2018).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…3 Importantly, perturbations in these physiological processes can lead to conditions such as preeclampsia, fetal growth restriction and preterm birth, which can arise without clear predictive biomarkers, necessitating extensive research for new biomarkers to enable a more personalised approach to pregnancy care. [4][5][6] Blood (plasma or serum) samples, collected during pregnancy provide a minimally-invasive and protein-rich source of biomarkers secreted from maternal, fetal and placental tissues. 7 In recent years, these samples have been analysed with a focus on gaining a deeper understanding of the complex molecular adaptations key for healthy pregnancy, as well as to investigate indicators of placental function, fetal, and maternal health associated with pregnancy complications.…”

Section: Introductionmentioning

confidence: 99%

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Longitudinal profiling of the pregnancy plasma proteome through organic solvent precipitation and nano LC-MS/MS

George,

Cook,

Smith

et al. 2023

Preprint

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Proteins secreted from maternal, fetal, and placental tissue are vital for processes like placental development, immunotolerance, and fetal growth, and are associated with pregnancy complications, necessitating predictive biomarkers. In this study, we introduce an acetonitrile-based precipitation coupled with solid-phase extraction that addresses limitations of current low throughput blood-based biomarker discovery workflows. Our method is efficient and cost-effective, and identified 433 protein groups, showing specific tissue associations and enrichment in reproductive tissues such as the placenta, breast, and endometrium. Significant alterations in proteins related to hormonal regulation, immune modulation, and placental development throughout gestation were observed. This approach offers comprehensive insights into the circulating pregnancy proteome, but also provides a scalable solution for larger studies for biomarker discovery in the context of pregnancy complications.TOC

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First trimester serum biomarker discovery study for early onset, preterm onset and preeclampsia at term

Cited by 9 publications

References 77 publications

Maternal serum alpha-1 antitrypsin levels in spontaneous preterm and term pregnancies

Maternal serum alpha-1 antitrypsin levels in spontaneous preterm and term pregnancies

Recognizing Early Warning Signs of Acute Hypertensive Crisis of the Postpartum Mother: An Important Role for Neonatal Nurses

Longitudinal profiling of the pregnancy plasma proteome through organic solvent precipitation and nano LC-MS/MS

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