First-trimester screening model for small-for-gestational-age using maternal clinical characteristics, serum screening markers, and placental volume: prospective cohort study

Kim, Young Ran; Park, Goeun; Joo, Eun Hui; Jang, Ji Hyon; Ahn, Eun Hee; Jung, Sang Hee; Jung, Inkyung; Cho, Hee Young

doi:10.1080/14767058.2021.1875434

Cited by 3 publications

(3 citation statements)

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“…Previous studies have shown that placental volume at delivery is associated with adverse pregnancy outcomes. 12,13 In our study, the risk of neonatal composite morbidity, including neonatal sepsis, retinopathy of prematurity, persistent ductus arteriosus, acute respiratory distress syndrome, bronchopulmonary dysplasia, and necrotizing enterocolitis, was higher in the group in which myomas including the IM type were removed than in the group in which only the SS type myomas were removed. Although not statistically signi cant, the group in which myomas, including the IM type, were removed, showed a lower placental weight compared to the group in which only SS type myomas were removed.…”

Section: Discussionmentioning

confidence: 48%

The association between clinical features at the time of non-hysteroscopic myomectomy before pregnancy and adverse obstetric and perinatal outcomes: a single-center retrospective cohort study

Kim

Jung

et al. 2022

Preprint

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BackgroundTo investigate the association of clinical characteristics at the time of non-hysteroscopic myomectomy before pregnancy and adverse obstetric outcomes in the next pregnancy.MethodsIn this retrospective cohort study, we identified 248 women who underwent abdominal or laparoscopic myomectomy for intramural (IM) and/or subserosal (SS) uterine myomas in Bundang CHA Medical Center before pregnancy and delivered at the same hospital between 2010 and 2020. The association between clinical characteristics at the time of myomectomy and subsequent obstetric outcomes were analyzed. ResultsThere was one case of uterine rupture. The gestational age at delivery was 37.7±2.4 weeks. There were 2 (0.8%) cases of fetal loss before 23 weeks, but there were no cases of perinatal death. The risk of transfusion during or after delivery was higher in the group in which multiple myomas were removed compared to the group in which only one was removed (aOR=2.41, 95% CI [1.20-4.86], p=0.014). The risk of neonatal composite morbidity was higher in the group in which myomas including the IM type were removed, than in the group in which only SS myomas were removed (aOR=14.29, 95% CI [1.82-99.57], p=0.012). Although not statistically significant, the group in which the sum of the diameters of the three largest myomas was greater than 15 cm showed a higher frequency of preterm birth (19.3% vs. 10.1%, p=0.001) and lower birth weight (2901± 625 g vs. 3063± 576 g, p=0.001) compared to the group with diameters less than 15 cm. Placenta accreta/increta (7.9% vs. 3.8%, p=0.043) and lower placental weight (646± 170 g vs. 750± 232 g, p=0.034) were more common in patients with an interval between myomectomy and pregnancy of less than 12 months compared to more than 12 months.ConclusionsTo our knowledge, this is the first study to investigate the association between clinical features at the time of myomectomy before pregnancy and various adverse obstetric and perinatal outcomes. If the removed myomas are multiple, IM, large, or the interval between myomectomy and pregnancy is short, the risk of obstetric and neonatal complications may increase.

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Section: Discussionmentioning

confidence: 48%

The association between clinical features at the time of non-hysteroscopic myomectomy before pregnancy and adverse obstetric and perinatal outcomes: a single-center retrospective cohort study

Kim

Jung

et al. 2022

Preprint

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“…When 0.96 MOM was taken as the threshold for PAPP-A, the sensitivity was determined to be 70%. PAPP-A could be a parameter to predict the pregnant women who may develop hypertension (Kim et al, 2021). In the literature, the study by Hendrix et al, compared the biochemical markers of the first-trimester screening test of 222 pregnant women with preeclampsia and 47,770 control cases.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Effectiveness of First Trimester Nucal Translucence, Free Beta-Human Chorionic Gonadotropin, and Pregnancy-Related Plasma Protein-A in Prediction of Pregnancy Complications

SUMAN

BÜTÜN

BÜYÜK

et al. 2022

Black Sea Journal of Health Science

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Abstract Objective:In this study, we aimed to investigate whether there is a relationship between NT and serum markers PAPP-A and β-hCG values measured in the first-trimester screening test, and birth weight and hypertension. Keywords: First trimester NT,PAPP-A, β-hCG, birthweight, preeclampsia Materials-Methods:454 pregnant women who underwent the first trimester Down syndrome screening test were included in the study. All the measurements and values of NT, PAPP-A, and β-hCG levels were done between the weeks of 11-14 pregnancies. The values of PAPP-A and β-hCG converted to multiples of the corrected median (MoM) were determined with the PRISCA software package. Results:In terms of predicting SGA infants, when PAPP-A value was

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“…These molecules are secreted into the maternal circulation while GA advances and are considered candidate biomarkers for pregnancy complications [40]. A growing body of evidence supports that components of the IGF system play a central role in the regulation of fetal growth [41][42][43][44] and that they are dysregulated at the maternalfetal interface and in the biological fluids of women with preeclampsia [24,[45][46][47][48][49][50][51][52][53], hemolysis, elevated liver enzymes, low platelet count syndrome [54,55], intrauterine growth restriction [20,22,46,50,[56][57][58][59], and gestational diabetes mellitus [23] as well as preterm prelabor rupture of the membranes [21,46], preterm birth [46,50,60,61], and fetal death [46].…”

Section: Components Of the Igf Systemmentioning

confidence: 99%

Further Evidence that an Episode of Premature Labor Is a Pathologic State: Involvement of the Insulin-Like Growth Factor System

Prasad¹,

Romero²,

Chaiworapongsa³

et al. 2023

Fetal Diagn Ther

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Introduction: Approximately 47% of women with an episode of preterm labor deliver at term; however, their infants are at greater risk of being small for gestational age and for neurodevelopmental disorders. In these cases, a pathologic insult may disrupt the homeostatic responses sustaining pregnancy. We tested the hypothesis of an involvement of components of the insulin-like growth factor (IGF) system. Methods: This is a cross-sectional study in which maternal plasma concentrations of pregnancy-associated plasma protease (PAPP)-A, PAPP-A2, insulin-like growth factor-binding protein 1 (IGFBP-1), and IGFBP-4 were determined in the following groups of women: (1) no episodes of preterm labor, term delivery (controls, n = 100); (2) episode of preterm labor, term delivery (n = 50); (3) episode of preterm labor, preterm delivery (n = 100); (4) pregnant women at term not in labor (n = 61); and (5) pregnant women at term in labor (n = 61). Pairwise differences in maternal plasma concentrations of PAPP-A, PAPP-A2, IGFBP-1, and IGFBP-4 among study groups were assessed by fitting linear models on log-transformed data and included adjustment for relevant covariates. Significance of the group coefficient in the linear models was assessed via t-scores, with p < 0.05 deemed a significant result. Results: Compared to controls, (1) women with an episode of premature labor, regardless of a preterm or a term delivery, had higher mean plasma concentrations of PAPP-A2 and IGFBP-1 (each p < 0.05); (2) women with an episode of premature labor who delivered at term also had a higher mean concentration of PAPP-A (p < 0.05); and (3) acute histologic chorioamnionitis and spontaneous labor at term were not associated with significant changes in these analytes. Conclusion: An episode of preterm labor involves the IGF system, supporting the view that the premature activation of parturition is a pathologic state, even in those women who delivered at term.

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First-trimester screening model for small-for-gestational-age using maternal clinical characteristics, serum screening markers, and placental volume: prospective cohort study

Cited by 3 publications

References 28 publications

The association between clinical features at the time of non-hysteroscopic myomectomy before pregnancy and adverse obstetric and perinatal outcomes: a single-center retrospective cohort study

The association between clinical features at the time of non-hysteroscopic myomectomy before pregnancy and adverse obstetric and perinatal outcomes: a single-center retrospective cohort study

Analysis of the Effectiveness of First Trimester Nucal Translucence, Free Beta-Human Chorionic Gonadotropin, and Pregnancy-Related Plasma Protein-A in Prediction of Pregnancy Complications

Further Evidence that an Episode of Premature Labor Is a Pathologic State: Involvement of the Insulin-Like Growth Factor System

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