First trimester mean arterial blood pressure is associated with placenta accreta: a retrospective study

Abstract

Objective The present study investigated whether first trimester mean arterial blood pressure (MAP) differed among pregnancies with placenta accreta and healthy pregnancies. Methods We recruited 152 pregnant females from 1 January 2016 to 30 January 2020 in the Affiliated Hospital of Jining Medical University in this study, including 41 cases of placenta accreta pregnancies and 111 cases of BMI- and age-matched healthy pregnant controls. First trimester MAPs were acquired from laboratory data files of the Affiliated Hospital of Jining Medical University. Multiple logistic regression analysis was used to analyze the probable risk predictor of placenta accreta. Results The performance of MAP was lower in healthy pregnancies. The MAP of the placenta accreta group was significantly higher than that of the control group (p = 0.001 < 0.05). Our results also showed that MAP was significantly positively associated with placenta accreta after adjusting for age, BMI, fertilization type, gestational week at time of blood pressure measurement, and previous cesarean section history (odds ratio [OR]: 1.11; 95% confidence interval [CI]: 1.04–1.69; p = 0.0013 < 0.05). In addition, smoking during pregnancy (OR: 7.57; 95% CI: 1.41–40.72; p = 0.018 < 0.05) and previous cesarean section history (OR: 2.57; 95% CI: 1.19–5.54; p = 0.016 < 0.05) were significantly positively associated with placenta accreta. Conclusions Increased first trimester MAP was significantly positively associated with placenta accreta, suggesting the potential role of MAP in identifying high-risk pregnancies for placenta accreta. Smoking during pregnancy and previous cesarean section history may be risk factors for placenta accreta.