First trimester concentrations of the TTR-RBP4-retinol complex components as early markers of insulin-treated gestational diabetes mellitus

Fruscalzo, Arrigo; Londero, Ambrogio P.; Driul, Lorenza; Henze, Andrea; Tonutti, Laura; Ceraudo, Maria; Zanotti, Giuseppe; Berni, Rodolfo; Schweigert, Florian J.; Raila, Jens

doi:10.1515/cclm-2014-0929

Cited by 26 publications

(25 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another case-control study found participants in the highest quartile of serum RBP4 had a 1.89 times higher risk of GDM compared with participants in the lowest quartile, while the relationship did not reach statistical significance after adjustment for maternal age, race, family history of diabetes, and pre-pregnancy overweight status [21]. However, Fruscalzo et al [9] found the concentrations of RBP4 in 11 insulin-treated GDM cases were significantly lower than 44 controls. Another research revealed an insignificant difference in serum concentrations of RBP4 between women who developed GDM and controls [22].…”

Section: Discussionmentioning

confidence: 97%

“…A meta-analysis pooled results from 14 casecontrol studies reported that the serum RBP4 level was associated with the risk of GDM (pooled standardized mean difference = 0.816) [8]. Nevertheless, this metaanalysis only includes one article in the "before 24 weeks" subgroup and no association between serum RBP4 level and GDM risk was found [9]. Recently, a prospective study revealed that early pregnancy RBP4 concentrations were associated with increased risk of GDM [7].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Plasma retinol-binding protein 4 in the first and second trimester and risk of gestational diabetes mellitus in Chinese women: a nested case-control study

et al. 2020

View full text Add to dashboard Cite

Background: To assess the association between plasma retinol-binding protein 4 (RBP4) levels both in the first trimester and second trimester and risk of gestational diabetes mellitus (GDM). Methods: Plasma RBP4 levels and insulin were measured among 135 GDM cases and 135 controls nested within the Peking University Birth Cohort in Tongzhou. Multivariable linear regression analysis was conducted to assess the influence of RBP4 levels on insulin resistance. Conditional logistic regression models were used to compute the odds ratio (OR) and 95% confidence interval (CI) between RBP4 levels and risk of GDM. Results: The GDM cases had significantly higher levels of RBP4 in the first trimester than controls (medians: 18.0 μg/ L vs 14.4 μg/L; P < 0.05). Plasma RBP4 concentrations in the first and second trimester were associated with fasting insulin, homeostasis model assessment for insulin resistance (HOMA-IR), and the quantitative insulin sensitivity check index (QUICKI) in the second trimester (all P < 0.001). With adjustment for diet, physical activity, and other risk factors for GDM, the risk of GDM increased with every 1-log μg/L increment of RBP4 levels, and the OR (95% CI) was 3.12 (1.08-9.04) for RBP4 in the first trimester and 3.38 (1.03-11.08) for RBP4 in the second trimester. Conclusions: Plasma RBP4 levels both in the first trimester and second trimester were dose-dependently associated with increased risk of GDM.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Plasma retinol-binding protein 4 in the first and second trimester and risk of gestational diabetes mellitus in Chinese women: a nested case-control study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…These three peptides were demonstrated to be precursors of clusterin, isoform 1 of fibrinogen alpha chain and apolipoprotein CII[ 85 ]. Similarly, other studies using these novel techniques, have shown that glycosylated fibronectin[ 86 ] and the transthyretin-retinol binding protein-retinol complex[ 87 ] were early predictors of GDM, even before the onset of glucose intolerance.…”

Section: Etiology and Pathophysiology Of Gdmmentioning

confidence: 90%

Gestational diabetes from A to Z

Dirar¹,

Doupis

2017

WJD

141

View full text Add to dashboard Cite

Gestational diabetes mellitus (GDM) is defined as any degree of hyperglycaemia that is recognized for the first time during pregnancy. This definition includes cases of undiagnosed type 2 diabetes mellitus (T2DM) identified early in pregnancy and true GDM which develops later. GDM constitutes a greater impact on diabetes epidemic as it carries a major risk of developing T2DM to the mother and foetus later in life. In addition, GDM has also been linked with cardiometabolic risk factors such as lipid abnormalities, hypertensive disorders and hyperinsulinemia. These might result in later development of cardiovascular disease and metabolic syndrome. The understanding of the different risk factors, the pathophysiological mechanisms and the genetic factors of GDM, will help us to identify the women at risk, to develop effective preventive measures and to provide adequate management of the disease. Clinical trials have shown that T2DM can be prevented in women with prior GDM, by intensive lifestyle modification and by using pioglitazone and metformin. However, a matter of controversy surrounding both screening and management of GDM continues to emerge, despite several recent well-designed clinical trials tackling these issues. The aim of this manuscript is to critically review GDM in a detailed and comprehensive manner, in order to provide a scientific analysis and updated write-up of different related aspects.

show abstract

“…More emphasis is placed on using interpretative, encouraging, persuasive language to explain relevant knowledge to patients and clarify their necessity. Relieve tension and fear, which helps patients actively cooperate with treatment [6][7]. Detailed patience expresses the necessity of surgery and the safety of the surgical procedure.…”

Section: Clinical Data and Methodsmentioning

confidence: 99%

Application of Prenatal Health Education and Nutrition Intervention in Patients with Pregnancy-induced Hypertension

Pan¹,

Yang²

2018

Proceedings of the 8th International Conference on Education, Management, Information and Management Society (EMIM 2018)

View full text Add to dashboard Cite

Abstract. Objective, to use prenatal health education and nutritional intervention strategies for pregnant women with pregnancy-related hypertension to explore the effect of interventions on patient outcomes and analyze them. Methods, a total of 90 pregnant women with gestational hypertension were selected and randomly divided into the observation group and the control group by random number method. The control group used the routine intervention nursing method. The observation group used prenatal health education and nutritional guidance. The values of blood pressure changes, delivery methods, weight changes, and other indicators were analyzed. Results Compared with the results of the control group, the normal rate of body weight gain during pregnancy in the observation group was significantly higher than that in the control group, and the difference between the groups was significant (P>0.05). In the observation group, the degree of satisfaction was significantly higher than that in the control group, with significant differences between groups. There was a statistically significant difference (P <0.05). The blood pressure of pregnant women in the observation group decreased significantly (P <0.05). Conclusion, The use of prenatal health education and nutritional intervention in patients with pregnancy-induced hypertension can help patients understand health knowledge, change their bad habits, and can help patients to improve clinical curative effect and improve the quality of life of patients. Maternal birth process progressed smoothly, effectively improving the outcome of childbirth, which is worth learning from in clinical practice.Pregnancy-induced hypertension is a common and unique disease that affects the life and health of pregnant women and perinatal babies. It is also a common complication during maternity gestation. The current stage is the second cause of death from maternal deaths in China. The main clinical manifestations include high blood pressure, proteinuria, and edema, severe symptoms such as headache, coma, convulsions, and even maternal and child deaths. Prenatal examination and treatment awareness are enhanced, and maternal mortality caused by pregnancy-induced hypertension is greatly reduced [1][2] . Therefore, if the prevention and treatment are not treated in time or the method selection is not appropriate, and a series of more serious complications are caused, the condition will progress to severe pre-eclampsia or even eclampsia, threatening the life safety of the mother and child. The importance of obstetricians should be emphasized on this issue, and the prevalence of pregnancies in pregnant women is currently on a sharp upward trend. The disease is more frequent in the second trimester of pregnancy. It is easy to restrict the growth and development of fetuses with pregnancy-induced hypertension, cause maternal dystocia, or cause more severe birth injury, and the mortality rate shows a significant upward trend. According to relevant investigation reports, the main cause of the disea...

show abstract

First trimester concentrations of the TTR-RBP4-retinol complex components as early markers of insulin-treated gestational diabetes mellitus

Abstract: First trimester maternal serum ROH, RBP4 and TTR represent potential biomarkers associated with the development of iGDM.

Cited by 26 publications

References 42 publications

Plasma retinol-binding protein 4 in the first and second trimester and risk of gestational diabetes mellitus in Chinese women: a nested case-control study

Plasma retinol-binding protein 4 in the first and second trimester and risk of gestational diabetes mellitus in Chinese women: a nested case-control study

Gestational diabetes from A to Z

Application of Prenatal Health Education and Nutrition Intervention in Patients with Pregnancy-induced Hypertension

Contact Info

Product

Resources

About