First trimester assessment of Pentraxin-3 levels in women with primary unexplained recurrent pregnancy loss

Ibrahim, Moustafa I.; Harb, Hisham M.M.; Ellaithy, Mohamed; Elkabarity, Rania Hamdy; Abdelgwad, Marwa Hussein

doi:10.1016/j.ejogrb.2012.07.016

Cited by 18 publications

(11 citation statements)

References 31 publications

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“…Ibrahim et al compared levels of PTX-3 in the serum of patients with primary and recurrent pregnancy loss and in women with successful pregnancies during the same week of pregnancy. Their results showed that levels of PTX-3 were highest in women who miscarried and correlated with the number of earlier pregnancy losses 25 . The results of this study correspond with those of Ibrahim et al Furthermore, within this study, the highest values of PTX-3 were seen in samples obtained from women falling into the NETs-positive group which indicates that levels of PTX-3 increase along with an increase in the associated NETs factors.…”

Section: Discussionmentioning

confidence: 99%

“…Earlier research on PTX-3 in NETs showed that PTX-3 plays a key role in regulating the proper development of pregnancy and the inflammatory response, such as in preeclampsia. An uncontrolled inflammatory reaction is believed to be the primary cause of unexplained recurrent pregnancy loss 24 , 25 . It has been proven that the gene responsible for PTX-3 activation is activated during the early gestation period.…”

Section: Discussionmentioning

confidence: 99%

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Biomarkers of neutrophil extracellular traps (NETs) and nitric oxide-(NO)-dependent oxidative stress in women who miscarried

Omeljaniuk

Jabłońska

Garley

et al. 2020

Sci Rep

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Pregnancy loss is a multidisciplinary problem which concerns researchers from the fields of medicine, epidemiology, psychology, and public health. The primary objective of the present study was to explain the potential role of neutrophil extracellular traps (NETs) in the process of spontaneous miscarriage. Enzyme-linked immunosorbent assay to assess the levels of biomarkers of NETs in the serum of examined women was conducted. Furthermore, levels of nitric oxide (NO) and late markers of its action were measured in serum samples. Analyses results demonstrated the existence of NETs in the placental tissue of women who miscarried as well as a simultaneous increase in the levels of myeloperoxidase and pentraxin 3. This clearly confirms the participation of NETs in the course of pregnancy loss. Women who have had a miscarriage but did not show the presence of NETs in their placenta exhibited the highest contents of NO, nitrotyrosine, and malondialdehyde suggesting a different pathway leading to pregnancy loss associated with disturbed oxidative–antioxidative processes. Although study results demonstrate new aspects associated with the formation of NETs they are not, however, sufficient to unambiguously determine the role of NETs in the course of miscarriage.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Biomarkers of neutrophil extracellular traps (NETs) and nitric oxide-(NO)-dependent oxidative stress in women who miscarried

Omeljaniuk

Jabłońska

Garley

et al. 2020

Sci Rep

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“…Metwally et al (21) performed a proteomic analysis of obese and overweight women with RSA by 2-D gel electrophoresis, principle component analysis and mass spectrometry, and demonstrated that RSA patients exhibit a significant increase in haptoglobin expression. Ibrahim et al (22) demonstrated that pentraxin-3 indicates the presence of abnormally exaggerated intrauterine inflammation that may cause pregnancy failure in females with unexplained RSA. Kim et al (23) identified RSA-associated factors in human blood samples by 2-D gel electrophoresis, and analyzed spots samples with matrix-assisted laser desorption/ionization-time of flight/mass spectrometry, and reported that in RSA patients, inter-α-trypsin inhibitor heavy chain family member 4 (ITI-H4) expression was low and exhibited a molecular weight of 120 kDa in controls; however, ITI-H4 was expressed at higher levels and at a modified molecular weight of 36 kDa in the RSA patient group.…”

Section: Discussionmentioning

confidence: 99%

Serum biomarker analysis in patients with recurrent spontaneous abortion

Guo

et al. 2017

Molecular Medicine Reports

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Recurrent spontaneous abortion (RSA) occurs in 1–5% of parturients. The sustained therapy and research for RSA is expensive, which is a serious issue faced by both patients and doctors. The aim of the present study was to detect protein expression profiles in the serum of RSA patients and healthy controls, and to identify potential biomarkers for this disease. A 1,000-protein microarray consisting of a combination of Human L-507 and L-493 was used. The microarray data revealed that eight serum protein expression levels were significantly upregulated and 143 proteins were downregulated in RSA patients compared with the healthy controls. ELISA individually validated 5 of these 151 proteins in a larger cohort of patients and control samples, demonstrating a significant decrease in insulin-like growth factor-binding protein-related protein 1 (IFGBP-rp1)/IGFBP-7, Dickkopf-related protein 3 (Dkk3), receptor for advanced glycation end products (RAGE) and angiopoietin-2 levels in patients with RSA. Sensitivity and specificity analyses were calculated by a receiver operating characteristics curve, and were revealed to be 0.881, 0.823, 0.79 and 0.814, with diagnostic cut-off points of 95.44 ng/ml for IFGBP-rp1, 32.84 ng/ml for Dkk3, 147.27 ng/ml for RAGE and 441.40 ng/ml for angiopoietin-2. The present study indicated that these four proteins were downregulated in RSA samples and may be useful as biomarkers for the prediction and diagnosis of RSA. Subsequent studies in larger-scale cohorts are required to further validate the diagnostic value of these markers.

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“…The classification of “unexplained etiology” required a lack of antiphospholipid antibodies (i.e. lupus anticoagulant and anticardiolipin) and normal test results for karyotyping (maternal and paternal), oral glucose tolerance, and thyroid function . Women with missed spontaneous abortion in the first trimester of the present pregnancy, but with no history of REPL and at least one previous uneventful pregnancy with no adverse outcomes were enrolled into a control group.…”

Section: Methodsmentioning

confidence: 99%

Retracted: Maternal serum amyloid A level as a novel marker of primary unexplained recurrent early pregnancy loss

Ibrahim

Ramy

Abdelhamid

et al. 2017

Intl J Gynecology & Obste

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First trimester assessment of Pentraxin-3 levels in women with primary unexplained recurrent pregnancy loss

Cited by 18 publications

References 31 publications

Biomarkers of neutrophil extracellular traps (NETs) and nitric oxide-(NO)-dependent oxidative stress in women who miscarried

Biomarkers of neutrophil extracellular traps (NETs) and nitric oxide-(NO)-dependent oxidative stress in women who miscarried

Serum biomarker analysis in patients with recurrent spontaneous abortion

Retracted: Maternal serum amyloid A level as a novel marker of primary unexplained recurrent early pregnancy loss

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