First total synthesis of (−)-α-conidendrin

Applications of Friedel–Crafts reactions in total synthesis of natural products

“…As a result, (−)-α-conidendrin 10 was provided as the desired natural product from 12 in satisfactory yield ( Scheme 2 ). 41 …”

Lignans neolignans, and related compounds

“…128 have carried out asymmetric syntheses of (-)-a-conidendrin and an analogue as shown in Scheme 38. Thus, bromination at the benzylic position of the appropriate monobenzyl lactone, followed by introduction of a benzyloxy group and alkylation afforded the dibenzyl-butyrolactone (173).…”