Abstract:The first total synthesis of the proposed structure of pandangolide 1 is reported. The synthesis was carried out using both an organocatalytic approach and a chiral‐pool approach. The required stereochemistry at C‐3 and C‐5 was installed by using an organocatalytic aldol reaction and a stereoselective ketone reduction. The construction of the 12‐membered core was achieved by 2‐methyl‐6‐nitrobenzoic anhydride‐mediated Shiina lactonization. The structure of target molecule was confirmed unambiguously by single‐c… Show more
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